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You condition the animal to do a certain behaviour when hearing sounds. For example the animal gets electric shocks shortly after a sound is...
To explain it very quickly: Some papers showed, that NHPN-1010 increases the BDNF concentration (not sure whether studies where animal studies or...
I can totally relate. My tinnitus changed from mild to 24/7 in the last 6 months of my studies. The final worsening happened only days after...
I would still be very cautious as to put too much hope into SPI-1005. What made me wonder in the last weeks is the death of Kent Taylor....
This would have made sense if I had used an e-commerce platform or for example PayPal. But this was old school just via email (I found the...
I did not even have to test the sample (I still will for sure, simply because I have access to NMR spectroscopy). Basically the package I got sent...
As a warning to everyone trying to order Ebselen or other chemicals from China: Request first a sample to test for a low price before ordering a...
As far as I know it has not even started yet. According to this website it will probably be completed in April 2023...
FX-322 was great as it had the promise to cure the problem at (one of) its roots and also because it was being developed rapidly. After the...
Jumping on the habituation bandwagon maybe?
The whole situation stills feels so unreal. I also still cannot get over the fact how FREQ acted so positively over the last weeks and the results...
I still have the feeling we have not consolidated on a clear statement what to make out of the results of the Phase 2. Agreed: it was a disaster...
I guess most of us had a hard time believing you since your statements have been very enigmatic and without (solid) proof. May I ask since now all...
I agree with you - besides the two days when I woke up with sudden deafness in my ear, this is the worst day of my life. 2021 did start so well...
Did we already see the extended audiogram changes? I mean it is plausible that more injections do not help with the lower frequencies, but maybe...
If you are interested in synthesising, here are the different ways of synthesising it:...
So your lowest "dip" is 5dB? It is just very surprising to me, that such a low dip can cause tinnitus. The only explanation I could have is that...
Does anybody know the approximate bioavailability of Ebselen when taken orally? I've skimmed many papers about Ebselen but so far I could not find...
If your lowest dip in standard audiogram is only 5 dB then probably this won't be the cause. Have you checked your higher frequencies (above 8...
For some reason Les Misérables' "One Day More" (caution: link leads to a song on YouTube) really comes into my mind when thinking about what might...
I just found this paper about the clinical trial of SPI-1005 where they evaluated its efficacy for preventing NIHL: Safety and efficacy of...
If he had sold because he already knew something about the results of the clinical trial(s), this would have been insider trading — which is...
I hope that they will continue Phase 3 even with these "bad results". If they can show that high frequency hearing regeneration can significantly...
The current consensus is that the current delivery method will likely work better for higher frequencies, since not enough of both molecules (but...
Another reason might be that VPA alone could also deplete support cells (see @Aaron91's post in the Pipeline Therapeutics thread). So maybe it is...
In the Frequency Therapeutics thread there was a vivid discussion about the VPA concentration dropping much faster than the propriety molecule. If...
Thank you very much for the reply! [ATTACH] I really like how they show the comparison between BDNF (OTO-413) and HPN-07. If HPN-07 (+NAC)...
Can you maybe provide me some sources for this? So far I have not found any clear statement for it (I did not find any so far - except for the...
But do we really know for sure that the ‘bomb blast’ pill by HEI is also repeating/creating synapses? I have listened to the Tinnitus Talk...
For me personally, having the loudest tinnitus is not really a competition. No matter how we got tinnitus, no matter what the true underlying...
I guess most Tinnitus Talk members who invested in FREQ have done it for the long run. We all know that investing into Biotech is risky and if...
Considering the series of bad news from Otonomy: what are our alternatives of drugs curing already existing and chronic synaptic damage?
If the current trial shows only improvements above 8 kHz, they could still make Phase 3 and bring it to market afterwards, or am I mistaken? In...
The good thing about this trial is that it will show whether IHC and OHC will be fixed in the areas where FX-322 does reach. If it significantly...
Out of curiosity: Can't we use the pharmacokinetics model of FX-322 as a basis to assume how deep OTO-413 might reach? I mean if we compare the...
Probably not the right channel but: Is there already any consensus in the community as to whether NHPN-1010 (HPN-07 + NAC) has any ability to...
As there is always a lot of talk about the astronomical prices of the molecules involved in the drugs (most notably for SPI-1005 and HPN-07): The...
