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This was before the disappointing results. From the newest report: “In light of the challenging financing environment, we intend to explore...

Disagree. There are at least 6 companies working on different hair cell programs right now: Frequency Therapeutics, Otonomy, Decibel Therapeutics,...

The audiogram was not performed inaccurately. The audiogram is a highly inaccurate way of measuring hearing.

I wouldn't worry about it. Just give yourself some time to relax and things should go back to the way it was before you were exposed to these sounds.

You are fine. 50 dB is way too quiet to cause any damage.

You did it again! You throw out big claims with no data to back them up. I would love to take a look at the dozen pre-clinical studies that have...

Please show me the data backing up these statements. There are things in the works, yes, but "curable"? "Preventable"? Big words you are throwing...

You're right, they removed it... Kudos to whoever archived the web page back in April....

I was just referring to NIHL in general. They are definitely not running to the gun range afterwards, but I think the theory Chad presented is...

It's all speculation. These are businesses trying to deliver a product into a market where there are no current therapeutic options. Stop acting...

This is incorrect. Outer hair cells are extremely delicate, and NIHL is indeed caused by exposure to loud noises over time, but also from very...

If it's any consolation, steroids normally help restore some hearing with sudden hearing loss, and sometimes with noise-induced hearing loss. If...

Depending on how precise the measurement is, I'm guessing they could measure objective changes in tinnitus for potential treatments. A pretty...

How is your audiogram? What frequencies does it show hearing loss and how much?

Look up cochlear organoids. It's being used to test these kinds of things.

One of the inclusion criteria was: Subject has audiometrically-defined normal hearing or up to moderately severe hearing impairment. Doesn't...

[MEDIA]

For any illness or disorder, there will always be heterogeneities in what's causing it.

Fantastic news!

This year has so far brought some interesting developments, and within the next 4 months or so, we are seeing results from at least 3 different...

I get the impression that their drugs are well developed already, so surely part of the lay-offs were redundant staff?

Seems like they will present the results from PIPE-505 Phase 1/2a before, or at the Inner Ear Disorders Therapeutics Summit. The event takes place...

After a joint research collaboration phase, Boehringer Ingelheim will be responsible for further preclinical and clinical development, and...

From Boehringer OKs $100M biobucks deal for hearing loss R&D project: Progress has taken longer than originally planned. Otologic talked about...

Hough Ear Institute has been working on this for many years. The publications "Regeneration of mammalian cochlear and vestibular hair cells...

Huge news. Autigen Announces Collaboration with Boehringer Ingelheim to Discover and Develop Novel Treatments for Hearing Loss

Around 52:00 is what I'm assuming he was referring to. Seems to me like they are talking about gene therapy and not stem cell therapy?

Thank you. Do you have a timestamp?

Do stem cells actually destroy progenitor cells, or did you make this up? Any sources?

I wonder what the difference is between Lineage Cell Therapeutics' and Rinri Therapeutics' approach? Does anyone have any insight?

Here's a quote from the Frequency Therapeutics front page: "Millions are impacted by hearing loss. We're seeking to restore the clarity they've...

You think the first hearing restoration treatment is not marketable? [ATTACH]

Doesn't seem like it's even getting tested for tinnitus? How are you going to persuade a doctor to give it to you then? I see you posting in the...

It is a bit confusing, I'm hoping they're going to clarify things down the road.

Pipeline Therapeutics have changed their "About"-paragraph in their articles from the News-section from: Pipeline’s lead clinical program,...

Pipeline Therapeutics to Present at Upcoming March Investor Conferences They're having a presentation very soon. 32nd Annual Oppenheimer...

That's really disappointing, but thanks for the answer.

Was the removal of the numbing stuff optional? Could it be different depending on what they are using as a numbing agent?

Did they remove the numbing agent afterward? With suction?

That's completely different. The "earwax softening stuff" normally gets washed out during syringing or a normal shower. With an intratympanic...

I'm guessing the numbing agent is on the eardrum itself? I can't imagine that any ENT would actually remove a numbing agent from the eardrum with...

[MEDIA] "We expect Phase 2 clinical trials to begin this year." That was in 2020, does anyone know if the Phase 2 clinical trials were ever started?

I'm guessing the patient could find out after the trial results are published?

Does anyone know if damage to synapses can also affect thresholds? Has there been any research showing this?

New drug treatment hope for hearing loss Seems like a new article?

To my understanding, a theoretical improvement with FX-322 in audiograms would require complete damage to one of the hair cells around the...

If these are the only frequencies you can find any hearing loss, then you have great hearing. Don't stress it!

I like the analogies, but they are of course naive and inaccurate. The brain is arguebly one of the most complex things in the universe. The...

Maybe, maybe not. You are removing the brain from the equation though, but it's just speculation at this point. Hopefully time will tell.

Sadly, it could be a lot more complex than this. In my opinion, the extra gain from hearing aids help mask the tinnitus, just like listening to...

Yes, this is a part of cochlea repair. There are several companies trying to get drugs to market for this particular issue. There are also many...

Not really. Seems like certain solutions for regenerating hair cells/cochlea repair are inevitable at this point, so that's more of a when and...

I find it odd that they are not doing any audiogram measurements. I don't think regenerating hair cells for 10 kHz and up would really affect...

Couldn't this be hidden hearing loss be damage to hair cells outside of the tones tested, instead of synaptopathy?

Does FX-345 aim to also fix existing hair cells, or is it mainly to generate new and functional hair cells?

No problem, I get it. At the moment, my tinnitus (in both ears) is more in the background, so it doesn't bother me that much. When I had a spike...

It took a couple of weeks.

Last year I experienced something similar, where I had been exposed to some loud sounds first, and a week or so later I went to the dentist, where...

Exactly! And I'm not trying to shit on people who have tinnitus and that feels like an alternative treatment has helped them. I have tinnitus...