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New study here: Tinnitus following treatment with ultrasonic scaler
Agreed, but from my understanding, that is a direct result of the trauma itself, and it doesn't create chronic/fluctuating hydrops, correct? Very...
My response to this is that both tinnitus and hyperacusis are generally a symptom of something else, which explains why they both onset together....
Sounds like the distortion was diplacusis! You’re lucky it eventually resolved, though I’m sorry the hearing loss remained.
Whoa whoa, when was this proven? The Phase 2b trial tested for EHF improvement, yet the announcement this week reported no improvement in...
I mean, sure, but unless there’s something particular about the cochlea we’ve discovered from this, to me it would still make plenty of sense to...
Because hearing involves more than communication. Even if EHFs don’t “affect communication”, they are still involved in everyday sounds. Please...
*Easier to treat a symptom.
What if these subjects have hidden hearing loss? For example, I have a dip as narrow as about 940-980 Hz, with a tinnitus tone at 990 Hz.
Can you explain? From what I understand: 1. Certain hair cells are not intrinsically stronger than other hair cells. 2. In cases of SSNHL...
Not to get too off topic but wouldn't an anti-inflammatory also work to reduce excess fluid? If not, why does Prednisone work so well with...
Hard to say because it’s not like Ménière’s patients don’t also have SSNHL, and tinnitus from that. I’m endlessly unclear if those with Ménière’s...
Maybe a silly question, but Otonomy hasn't published their peer reviewed journal on the detailed results yet, right? (Similar to this for phase...
Uh oh...
I wonder in a decade, when this objective measuring is hopefully widespread (from the Bionics Institute or elsewhere), if some kind of retrial of...
But did we ever get evidence that extended high frequency thresholds actually improved via an EHF audiogram? Or is this just affecting synapses in...
This is what's so maddening to me, given we just saw this happen with FX-322. I guess it was maybe too late as Otonomy had already begun their...
Weren't the sample sizes of Phase 1 for this device and OTO-313 very similar, and didn't Phase 1 for both trials show positive results?
I thought a previous trial established no audiometric improvement of EHFs. I know we've seen some differences around 8 kHz, but I thought there...
@Sentinel, thoughts? Would love your take on this now that the cat's out of the bag.
Really great point and thanks for attaching that data chart. The one thing that’s keeping me (and I guess others) suspicious though: What do we...
I hope it’s good news too, but I assume that the “full dose” trial is also due to early data suggesting that a stronger dose would yield better...
Were these subjects from the OTO-313 group or the placebo group?
Absolutely yes—Phase 2 results alone will take a year to be released. Then factor in the time it takes for Phase 3 to start and then the time it...
Perhaps I just don’t know enough about FX-322’s mechanics, but is it accurate to say that the drug preferentially targets the extended high...
