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With most drugs, the rule of thumb in the presence of normal renal or hepatic function (depending upon how drug is excreted), is that “therapeutic” concentrations are reached after 5 half-lives have passed. If I take a first dose of a drug with a 24 hour half life, then half the dose is left...

My tinnitus, which started only 10 days ago, happened while taking 5 mg of Cialis daily or every other day for BPH (Bening Prostatic Hyperplasia). Only had 52 tablets over about 2-3 months. But, I had recently taken 4 weeks of Levaquin and was taking 6 weeks of Bactrim concurrently for a...