Separate names with a comma.
Hi, could you please tell me where you got the intratympanic steroid injection done? I'm in NYC and I can't seem to find any doctors that would do...
As to the $$$ side of things, have you looked at the online Canadian pharmacies?
Hmmm, this seems to go against Prof. Tzounopoulus's paper Pathogenic plasticity of Kv7.2/3 channel activity is essential for the induction of...
Can this neural signature be (strongly statistically) correllated with the subjective perception of tinnitus intensity? If so, has there been any...
Well, if he has no symptoms, and will continue to have no symptoms, for some time x in the future, then I think we can all agree that fits the...
My theory is that the key may be to replace the 'normal level target' that homeostatic mechanisms 'go back to'. It could be that the changes which...
Thank you for finding the paper, @locoyeti ! Just a question on the data bolded above - if the effective therapeutic concentration is 7.4um and at...
Very interesting...Does anyone have the full text of this article?
I agree too... Time for a flupirtine thread! And willing volunteers..
There are many hypotheses as to the mechanisms that cause and maintain tinnitus. These few pages...
I'm surprised this even needed FDA clearance. I mean, it's just an ipod with an app. Isn't that at odds with both the study it's supposed to be...
Right, but if input from the cochlea to, say, the DCN, was truly lost for some specific frequency, then how would you be able to 'fill in' for it...
Nice paper, but I have two comments/questions : 1. Perhaps the decrease in tinnitus intensity was due to better sleep quality, induced by the...
Purposeful malpractice would cost him much more than just his career...
This portion of the video says the stem cells are attracted to chemokines released near the area of injury : [ATTACH] But what are the...
Has the Aspartame - Tinnitus connection been firmly established? Or is it yet another unverified rumor or myth regarding the "dangers of aspartame".
What's the subject name, if you don't mind (just curious)?
I think this is an important bit. Look at what @SoulStation said : I suspect many others who have tried Retigabine share this view. It seems...
I was talking about esketamine (hydrochloride), which is what they inject in AM-101 trial (if you're not getting a placebo). Esketamine is a form...
I would think alot would depend on the rate that ketamine gets metabolized at - or rather, for how long does it stay attached to the NMDA...
Not really. Many people are routinely ordering illegal drugs online via the darknet. It comes to them by mail and they receive it just fine.
I think the connection to the DCN is not through the drug diffusing there but rather through the cessation of aberrant signaling from the cochlear...
I don't see how that necessarily follows from the definition you gave. From the definition, plasticity is not about recovery (to some 'normal'...
Yeah, but most if not all drugs are like that before a Phase I trial on humans - no one knows how humans will respond. (Although I guess more...
If you go to that link and select the country (e.g. USA), it says it's available and you can buy either 10mg or 50mg of it. Mpt was asking about...
Has anyone looked into Maxipost? Is it obtainable anywhere? (Perhaps here : http://www.tocris.com/dispprod.php?ItemId=383718 )?
I think the medicine is 'controlled' in the sense of the FDA not permitting GSK to just sell it without a prescription. But the chemical compound...
@attheedgeofscience : Any results to update about your experience with flupirtine?
Unless it's on a controlled substance list, I don't think there is any problem importing it, without any kind of license or governmental...
Instead of cutting the nerve, is it possible to 'disable' it temporarily - like anesthesize it with lidocaine or the likes? This will enable one...
Modern medicine, like almost any scientific discipline nowadays, has its theoretical underpinning in biology, which in turn has its base in...
Hopefully the amnesia is not permanent! :unsure: (that is, if you go off the drug, you have pre-drug levels of mind clarity). Also, perhaps the...
I'm taking NAC (2000mg/day). Is that much different than ALA (i.e. do you think I be taking ALA instead, or in combination with it)? Do you...
Why is that?
Surely some island nation or something like that would do.
On that note, why wait for UK approval at all? Just manufacture it in a country that has no drug approval policies, and order it from there :)
Perhaps it is possible to activate that enzyme only in the neurons responsible for hearing (like the spiral ganglion neurons). One way is to make...
One interesting section from the article : To summarize (according to how I understood it) - the molecular mechanism of why Kv7 channels close...
Hearing clicking/crackling sounds in the ears when swallowing happens (I guess) to everyone sometimes. But does Tinnitis make you hear this...
Yeah, but on the other hand, some people try street drugs without knowing what's in them, and couldn't care less. Still others, like Alexander...
I don't think it's so much that it's different systems rather than completely different conditions/causes. In case of MS, it seems like it's the...
It could also be that aut00063 will prove in fact prove ineffective, and retigabine will prove effective. That, for instance, would give us a clue...
Well, there are things like, say, white-noise generators that mask the tinnitus. So that fits the "alleviate the symptoms temporarily" criteria....
Sorry, I don't know if I could have made it more clear. I'm just trying to get to the bottom of things in terms of understanding. I'm not trying...
The bolded part above is what requires explanation. Here we have a neuron, and the subcellular location of Kv channels [ATTACH] Figure...
Fun reply with graphics, but I'm still not sure it answered the question it posed : So the question is : what's the link between glutamate...
Nanotechnology is the most obvious (but perhaps hard to implement right now) method - you just have nanobots attach to synapses and measure firing...
How about this little idea - instead of fiddling with the Kv channels to control the firing of the cell, find a way to DESTROY the haywire cell...
I don't think blanket statements like this are true. It really depends on the details and specifics. In particular, it may depend on whether the...
This is still where I'm very unclear. What is the nature of the interference with the excitability of spiral ganglion neurons? Here's a chain of...
I was reading this paper http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2011.03365.x/full on the mechanism of action of Retigabine, and it...
That section ("KATP channels in glutamate mediated synaptic degeneration", page 11, http://tinyurl.com/mrgwnxz) simply mentions that activating...
Hey, thanks for the graphical explanation :) After reading some more wiki, I think I more or less understand now - IF the potassium channel is...
Are you saying that there is some causative link between glutamate excitotoxicity and blocked Kv channels? I tried to find this in some articles...
