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This is the official clinicaltrails.gov page for the phase 1 trail of XEN1101 (with TMS): https://clinicaltrials.gov/ct2/show/NCT03468725 The...
Good news, but dont forget: One case is no case. Placebo is often a good but temporary remedy. The internet is full of trolls.
Well... in the 'dark scientific age' we live in, pre-clinical trails on animals who can't tell us if they have tinnitus, nor if any intervention...
At least.... an article that explains the Shore method thoroughly and understandable for Joe and Jane:...
Well ladies and gentleman... AMother-101 bites the dust:...
Just a quick update regarding XEN1101. Recruitment for the phase 1 trail has apparently started a month ago @RichardsonLab in London:...
Well... this is confusing. Apparently in treating T Aut63 turns out to be a very effective drug at lowering the symptoms as much as 60%... for...
Let's make that specific then. Where does funding for tinnitus research come from? The department of defence...national health services?? The...
This was only an anology. An example to explain that damage in the inner ear could trigger an overamplification in the brain to compensate for...
Nobody knows besides Autifony. Time will learn us.
Finally.... somebody that can reproduce my experience ;) But to avoid false positives you first need to try the 'sweep experiment' with different...
Yes No, at least not the sound I perceive. Because it is not probable that damage in the cochlea/nerve/brain is pinpointed to one frequency. A...
Yes, that's exactly what they have written.... and it is a fine example of scope narrowing due to risk avoidance. Modern research is influenced by...
Bumping this thread because there is a new paper on PubMed about KV3 and tinnitus (Charles Large is again one of the authors). The generation of...
Keeping myself busy with work, listening to music or walking outside (rich ambient noises work like a charm). When at home I use smartphone apps:...
Found this paper on Pubmed published yesterday (unfortunately no abstract): Sensory systems: Bimodal cochlear nucleus stimulation alleviates...
This confirms my earlier post. They have no clue if kv7.2 channels are the holy grail for T, but the fact that Retigabine did something for some...
Don't get disappointed if phase 1 doesn't show a noticeable effect for tinnitus. Phase 1 trails are purely intended as a safety check for drug...
Well... a recent (december 2017) researchpaper still reported positive effects of kv3.1 modulation with aut63 (failed in trails) on fast spiking...
No... the compound is called ketamine and they are injecting it intravenous (directly in your veins). AM101 is called esketamine and is injected...
New trial with Ketamine IV injection for the treatment of T started by New York State Psychiatric Institute. More info @...
They listened to you Karrie... New trial in New York started by New York State Psychiatric Institute. More info @...
Please stop spreading BS from depressed feelings without any factional arguments (referencing to WW2... yeah right). This is the chart on PubMed...
Yes, the man is still alive and working on Kv7.2/3 channels ;) http://phrc.pitt.edu/people/thanos-tzounopoulos By the way... the brand new...
No... not yet... but with our help some day they will... and with them we will...
Dr. Christopher R. Cederroth from the Karolinska Institutet in Sweden published an article about the fact that the tinnitus topic on Frontiers...
It's official ladies and gentlemen... phase 1 trial of XEN1101 (formerly known as 1OP-2198) will start in Q4 2017 with phase 2 following in second...
Good news... but it is still wise not to launch kv7 regulating drugs as the new holy promise of tinnitus treatment. Back in 2011 there was an...
Hi @TTP, first of all... don't panic. Your T is just 3 weeks on and there is a possibility it will go away (T less than 3 months isn't considered...
Who knows... from a logical point of view one could expect that the pre-clinical study probably only focused on the neurochemical regulation of...
Status update for RL648_81: [ATTACH]
No. The drug that Tzounopoulos developed is RL648_81 (no news about it since Q2 2016). This one is aquired by Xenon pharma last April and is...
Thanks for sharing your experience @Cal18 (y) Regarding the use of Olanzapine I can share that a close friend of mine who also suffers from T...
[ATTACH] Movie is a hit!!! Everybody to the cinema for more awareness (and don't forget the earplugs).
Mirapex = Pramipexole = https://www.tinnitustalk.com/threads/tinnitus-control-by-dopamine-agonist-pramipexole-in-presbycusis-patients.84/
Thank you very much that you made me laugh for the past 5 minutes @NatureHiker . Your capability to invert things up is wonderfull. Now... if...
Wow... @NatureHiker ... you do have some good qualities for dramatizing things up, don't you? Pittyfishing in a pool of likeminded won't help in...
Might have this...might have that... big pharma behaviour as usual... Maybe they can also add to the list that this new drug might be improve our...
The phase 3 trial is about BHV-4157 (Ataxia) and not about BHV-0223 (ALS). Also don't know why this thread exists since the candidate compound is...
They received an additional 20M$ :rockingbanana: for more research on hearing loss (and I hope tinnitus also). More information:...
There are all ready evidence based locations in the brain that are been identified by neuroscientists. One of the most interesting of them...
Thanks for your very informative explanation. (y) Big data computing is exactly the way to go. The complexity you are describing is however due...
An impressive and scientifically correct analysis you made above @Biomed. You seem exactly the right person with the right academic competencies...
Bumping up this thread because of a trial that has been going on in Regensburg Germany since 2015 with expected results in December 2017:...
Could you also inform us with a little bit more information about your experience: Which 2 meds were injected? For how long did you have...
This thread is not about Alprazolam (Xanax) but about Aripiprazole (Abilify). There is a huge difference in the mechanism of action between those...
Ok ladies and gents... time to share some interesting insights about a drug called Aripiprazole (aka Abilify) and its effects on our old friend...
A little remark about the effectivity of HA's in reducing your T sound. Probably it is due to auditory masking which is a build in feature of our...
Quick update: The phase 1 trail of this compound is set to take place in Q4 2017. The compound is licenced to another company called Xenon pharma...
Yes, that is exactly the problem... there are enough scam artist's with a PhD on... let's say chiropracty... that call themselves 'Dr'. The...
My dear Samir... the title of the article says 'is there a place for brain stimulation' with respect to tinnitus and the article has been...
So... I see that you are interested in the last insights about the neuroscience of tinnitus... Here is the link to a research paper written by...
I know a person who took Pramipexole and it diminished/lowered their tinnitus effectively. The summary of the case is: The dosage the man used...
[ATTACH] Just saw this on Twitter. Could be interesting to get more insights about research that has been conducted by NIHR. Somebody nearby...
Exactly my point of view Steve. As popular as Elon Musk is, he probably receives hundreds or thousands of messages every day. The chance of...
As I like to be a liaison for connecting similar trials, below a fMRI research in Groningen (The Netherlands) for gaze evoked tinnitus: [MEDIA]...
The man has built a reusable rocket with limited budget in a decade while NASA hasn't done anything innovative since the 70's with a budget that's...
Couple of weeks ago Neuralink, the new brain to machine start-up Elon Musk has created, was on the news. In the meantime a new website has been...
To be honest I don't think pharmaceuticals care about young people getting their T from iPhones or veterans getting them from machine guns and...
To be realistic... I think it would take another 5 to 10 years for approval of an effective drug... especially because of the unfortunate fact...
