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Thanks for clearing that up, and I'm really sorry to read about your recent symptoms.

I hope Ebselen does well. It was bad news about Otividex Phase 3 failing again and I sort of have this drug in the same category although they are different drugs. Could the placebo effect also be similar for the SPI-1005 Meniere's trial? And fail in the same way that Otividex did? @FGG?

I had a setback last night after doing quite well for a few weeks, just hope it's not a bad one. I'd do anything to try this stuff right now.

Here's some info on the trials. Pipeline of Sound Pharmaceuticals: https://soundpharma.com/pipeline/ ClinicalTrials.gov: https://clinicaltrials.gov/ct2/results?cond=Covid19&intr=Ebselen Nature article: https://www.nature.com/articles/s41586-020-2223-y

I wonder if also, an acoustic shock symptoms cluster and the damage it leaves behind could be relative to both these points above. As interrelated as the mid ear and cochlea pathology seem to be in noxacusis, they still appear to be fundamentally separate pathologies. Is a sensitized trigeminal...

This is one of the big questions (is the type II sensitization permanent regardless of what now gets fixed) and why I always end up going full circle through the possible treatments and ending up back at RL-81 and XEN as a catch-all in case it is. Whether or not sensitization is recoverable or...

@weab00 - Have another read of those models, because if you're unsure about the above in particular then they hypothesize on this exact point.

@weab00 - Yeh it is just speculation at the end of the day, using what little research we have to back it up. I wonder what's the point in doing it sometimes as well, and how reliable the research is that it's all based on. Just wait for the drugs to see what they do would be the easier option...

This is going to be interesting to see if it does do this, I really hope this is what happens once we finally get to test and see what it does indeed fix for noxacusis.

I couldn't agree more @serendipity1996. Ideally it would be fixed with a fully regenerative treatment. I was thinking the same thing today, its all good and well that say RL-81 now means no more noxacusis but what if there are nasty side effects for life from it? (I'd like to think that if I...

I'm not sure either but I've never found anything to say that type II's can become desensitized again. 'Selective activation of P2Y receptors increased type II afferent excitability by the closure of KCNQ-type potassium channels, a potential mechanism for the painful hypersensitivity (that we...

XEN-496 and XEN-1101 seem to be quite similar as you're probably aware, and RL-81 also seems to be much the same thing. A big difference I can see is that RL-81 is being developed with tinnitus in mind whereas the Xenon drugs are for epilepsy. "Selective activation of P2Y receptors increased...

...maybe what all noxacusis sufferers are really waiting for is the channel blockers. (Probably combined with an anti inflammatory of course).

I'm on the same page as you in that case. One of the things that bugs me as well is the sensitized Type IIs and what would be their potential response to a normalized cochlea where loud noise was concerned. I actually think I've been there. My first recovery was SO good, I even got to another...

I'm trying to understand what you're saying so bear with me, no doubt your science is way ahead of mine but I think I get it. When you say 'continuously cause setbacks', can you expand what you mean. Do you mean setbacks happening continuously upon hearing any random general noise, over and...

Yes agree. I'm also talking about the bad, excess, or 'leaking from the wrong place' ATP. (The type or quantity of ATP that begins to initiate pain and inflammation /activate the sensitized nociceptors?)

Really interesting. The only thing I'll say with regard to the question of 'is there continuous ATP leakage', I would lean towards it not being continuous, at least not continuous in a permanent sense. Maybe continuous for a period of time after a noise assault. I doubt it can be permanently...

The 2 things that I can't ignore is how obvious it is that raw noise at certain frequencies causes my setbacks, and that we have nociceptors in the cochlea that respond to ATP. To me those are facts. Your question above, is the burning question though, where does the ATP come from? If it's...

Exactly, I don't see how setbacks can necessarily be the result of fresh hair cell death every time either as I doubt the noise that typically triggers setbacks is anywhere near noxious. Enough to cause a fresh spark of ATP release though, yes definitely, and I believe that's where the short...

It's a delayed effect pain after a setback which is triggered by sound. Yes I agree, I admit I'm really pushing the theories with this now. After all I've read though there are 2 minutely theoretical ways I can see that the cochlear inflammation could possibly do this. 1) There are apparently...

I was just wondering if there was any particular view on it. I think, but not 100% sure, I've heard of people getting intratympanic steroid injections before for noxacusis in general, but it could have been for tinnitus and didn't do a lot for it from what I recall. I wonder if anyone could say...

This has probably been answered or at least would have been worked out by now but, for the facial pain side of noxacusis is there any effect on getting an intratympanic steroid injection? I'm not talking about it needing to diffuse to the inner ear, I'm talking about it staying in the middle...

I hope in theory it could calm cochlear inflammation very quickly after a setback. What I don't think it will do though is stop the actual setbacks in the first place which would need cochlea regeneration drugs. SPI-1005 could be a sort of 'setback bomb blast pill' in my mind. If the after...

I read this earlier. Am I reading this wrong that this drug is currently available anyway for certain conditions? (Bipolar and hearing loss). Would that not mean that it's deemed safe for possible off label use? Treating COVID-19: Bipolar drug shows promise and other hopeful findings

This is where I'm hoping that 'noxacusis setbacks = instant inflammation' and it can be taken as soon as you know one is on the way. I can only speak for myself but I know the distinct feeling when a noise has done enough to trigger an anticipated setback. I know regeneration would be the best...