Search results for query: *

It's interesting to see this from the Clinical Trials page: "Ebselen contains the mineral selenium and behaves like Glutathione Peroxidase, an enzyme that helps to rid the body of damaging chemicals caused by loud sounds" This grabbed my attention because I remember someone on here mentioning...

For the sake of many of us who are or who have been on the brink with this condition, could you please try to persuade this person to make an account of their experience with Ebselen so far somewhere on Tinnitus Talk? It would be great to hear it from the horse's mouth and for us to be able to...

I'm not sure, to be honest, but I remember someone on here posting previously about needing DMSO to take it. If you go on this lab's page and look at the solvent & solubility table, you will find the following for in vivo administration, which would seem to be consistent: 1. Add each solvent...

@weab00 doing God's work. Also worth noting that that 200mg was the low-dose version of the SPI clinical trials. Their results, for Meniere's at least, were better when taken at 400mg, if I remember correctly - 95% improvement relative to placebo (200mg saw 65% improvement). Value for money...

It's a million dollar question. For what it's worth, I came across this today on hyperacusis research. I'm sure I've read it before but I didn't make a mental note of it at the time. It's from the section about the ATP leakage theory: "This may tie in with our emerging understanding of...

Even if I had the funds to do it I’m not sure if I could bring myself to take it without knowing the full extent of the side effects and/or some kind of medical supervision. I rarely take a supplement without doing research first. Having said all this, I’ve had a really bad setback with my...

Do we have any examples from injuries to other parts of the body that could give us any clues here? I recall @serendipity1996 making the point that patients with chronic hip pain, regardless of how long they had it and how bad it was, seeing their pain resolve/improve after a hip replacement. So...

@FGG Ok, so my understanding is that they found an increased ABR wave III/1 ratio, which to your point suggests they are indeed seeing central sensitisation, or increased centralised activity. But they also follow that statement up with the following: "This evidence suggests that the amikacin...

@FGG I hope you don't mind if I press you on how we know this for sure, as the study doesn't seem to distinguish between the two different types. Is it not possible the mice in the study had both loudness hyperacusis and noxacusis? If I've understood the paper correctly, the method of testing...

Amazing find. Is anyone with hyperacusis thinking of ordering this from a lab?

This thing can't come soon enough. How long are we looking at until we can get this off-label?

I'm still experimenting and adding new supplements every week. I would say I have seen marginal benefits, but it's always difficult to know exactly whether it's down to any individual or combination of supplements or not. I felt the best I had felt until a couple of days ago, only for a friend...

As in the blood-labyrinth barrier? I have no idea, but apparently the active ingredients in Lion's Mane - hericenones and erinacines - have a low molecular weight, so they can easily cross the blood-brain barrier and stimulate NGF synthesis directly in the brain. Whether this means they can...

Just to follow up on this, I started taking Lion's Mane a couple of days ago as part of my own protocol because I read that it can help with neurogenesis and neuroinflammation. I already feel a bit sharper and my mood has been lifted, but as always it could just be placebo. But more...

Really interesting @FGG. What I'd be curious to know then is, assuming a drug like this could work for us hyperacusis sufferers by dampening hyperexcitability, is this something we would only have to take once or a short course of, or would we probably have to be on it for life? Or would it be...

Not to be pedantic, but it's interesting the wording used there is "further trigger" and not "trigger further". This would suggest that it is indeed the Hensen cells that are releasing ATP and not some other cells as well as Hensen cells, unless this is some kind of editorial oversight. However...

This is a tough question. My understanding is that the sensitisation is the result of ATP "leakage" because ATP is required for upregulation of P2x receptors. One of my long-standing questions with this theory is: what does one mean by ATP leakage? Does it mean an overflow of ATP from the OHCs...

@100Hz I did indeed miss that, so thank you for bringing it to my attention. Thank you also for reminding me that OHCs have their own corresponding type II afferent as it made me re-open up this diagram I saved some time ago and which I've now copied in below. What I had forgotten was that...

One of the things that has been playing on my mind @100Hz for a while now is your post from another thread, which I will repeat again here as I still haven't had anyone else's thoughts on this: "Likewise, measured ex vivo, synaptic excitation is weak and could activate type II afferents only if...

Perhaps this is wishful thinking, but I'm not convinced that once the fibres are activated then that is it. Without a doubt, cochlea damage has an element of permanence about it (at least until regenerative medicine hits the market), but from my little understanding of molecular biology and...

Let's assume for a minute that this drug is given the go-ahead in the coming months: how easy will it be for many of us to access it? I imagine governments would look to hog any meds that could be used to treat COVID-19 or its associated symptoms in case of a big outbreak. I also vaguely...