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Damn, but only loudness hyperacusis?

Depends on how the COVID-19 trial goes imo, if it’s approved for COVID-19 treatment, it should be approved next year.

Does that mean if you do well on benzos, that’s a sign SPI-1005 could be beneficial to you?

So you can buy Ebselen (SPI-1005) online. That’s pretty interesting. Does anyone know that dosage is used in the human trials?

So question, I remember people talking about synapse drugs helping noxacusis... Where would that fit in? Or has that been made obsolete by the latest mechanisms? I’m only asking because I feel like I do have synapses lost because I have hidden hearing loss more so than regular hearing loss.

Yup.

I’m an American and I’ll probably try to get it.

It’s a tablet. Pans if it passes it’s COVID-19 trial in April, probably soon after that COVID-19 is a high priority.

It’s likely to be the first available to the public. That helps.

Don’t forget XEN-496.

I just want to tell you that I really enjoy reading your well researched and realistic posts. You are one of my favorite people to read from in the Research News section.

Inflammation is covered by Sound Pharmaceuticals with their SPI-1005, this one may be becoming very soon because it can also be used for Covid. There’s a few working on synapses, the two I follow most closely are Otonomy with OTO-413 and Hough Ear Institute with their regeneration pill.

Never lose your optimism buddy, so many different treatments are coming out soon and they all work in a variety different ways. If your problem is cochlear inflammation, it’ll be fixed. If it’s hair cells, fixed. Synapses, fixed. Potassium channels, treated. Being optimistic is the realistic...

Considering the fact that no other drug has shown in a trial to reduce tinnitus for any reason (correct me if I’m wrong), people on this forum have the right to be excited. Especially considering the fact that this drug should also definitely be available in the next six months. There are...

And there’s no way it even takes a year to get a vaccine, every projection seems to think one will be available by next summer and that’s a pessimistic estimate. And I agree, it’s pretty obvious they’re going to do off label prescriptions. It’d be stupid not to. A drug like this for ears would...

Well if it makes you feel better, that probably won’t happen before next summer. We will likely have great news on FX-322 and OTO-314 by then. And this drug will likely be out. So even as life crashes, we will likely be getting very good news regarding our condition.

Even if that happens at first, and that’s a big if depending on where you live, COVID-19 is on its way to a vaccine so the pandemic can’t go on forever. And when it’s over, the government isn’t going to stop the company from selling its drug. But again, I don’t think that’s likely in wealthier...

I mean, at least in the US, off label prescriptions are written all the time. Just look at Gabapentin, it’s only approved for partial seizures and postherpetic neuralgia and yet look at the all scripts it has for all these pain disorders and anxiety and stuff, hell, look at how many people got...

Hey @PeteJ if you haven’t seen this thread yet, I’d take a look at it. This drug SPI-1005 could be here in a matter of months and it looks promising.

I’d say early 2021 because even after it’s approved, there’s stuff you have to do and we don’t know how ready Sound Pharmaceuticals is to launch the drug but I’d say Q1 2021 would be very likely if it passes the trial considering the fact that anything remotely related to COVID-19 is a top priority.

@FGG said earlier in the thread that the phase 2 COVID-19 trial ends in December, what a great Christmas gift it’d be if this drug is expedited and helps hyperacusis and tinnitus.

Yeah, I totally agree but having an effective pain killer and aid to help with hyperacusis pain in particular would be great and would make the time waiting for FX-322 and OTO-413 a lot more comfortable. Just not needing to worry about setbacks anymore would be a dramatic life improvement.

I do have hearing loss but if this drug put a real dent in my hyperacusis and tinnitus, I wouldn’t give a fuck about it.

Plus, I read articles in the Wall Street Journal that the trend is now to fast track drugs and they’re fast tracking more than ever. So it seems drugs are coming faster these days.

Imagine getting so lucky that your drug helps COVID-19 and you get to release it quicker as a result? That's like a drug maker's lottery win.

Yeah, that’s XEN-496, it is starting phase 3 this year. So that’ll be exciting. @weab00