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You condition the animal to do a certain behaviour when hearing sounds. For example the animal gets electric shocks shortly after a sound is played, or the animals get food at a certain spot while playing a sound. After one induced noise to the animals, they will behave different to the control...

I would still be very cautious as to put too much hope into SPI-1005. What made me wonder in the last weeks is the death of Kent Taylor. SPI-1005 and HPN-07 would have been easily available for a millionaire and surely one tries everything before going into drastic measurements. Obviously if...

This would have made sense if I had used an e-commerce platform or for example PayPal. But this was old school just via email (I found the supplier using chemicalbook.com) and bank wire, so there would have been 0 chance for me getting the money back in any case. Also I have to say that they...

I did not even have to test the sample (I still will for sure, simply because I have access to NMR spectroscopy). Basically the package I got sent contained a cheap foundation ingredient of cosmetics and all the declarations for customs as well as the shipping invoice stating the same. Since...

As a warning to everyone trying to order Ebselen or other chemicals from China: Request first a sample to test for a low price before ordering a larger quantity. I ordered from a Chinese supplier a probe to check and it turned out to be scam. So even if you are provided with legit NMR, HPLC...

As far as I know it has not even started yet. According to this website it will probably be completed in April 2023...

FX-322 was great as it had the promise to cure the problem at (one of) its roots and also because it was being developed rapidly. After the disaster with FX-322, we should lower our expectations. SPI-1005 will at most alleviate our problems, but not cure them. The beauty of SPI-1005, on the...

Does anybody know the approximate bioavailability of Ebselen when taken orally? I've skimmed many papers about Ebselen but so far I could not find any statement in that regard.

I just found this paper about the clinical trial of SPI-1005 where they evaluated its efficacy for preventing NIHL: Safety and efficacy of ebselen for the prevention of noise-induced hearing loss: a randomised, double-blind, placebo-controlled, phase 2 trial Interestingly, the 600 mg group...