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I seriously doubt FX-322 will be out by 2023, assuming it comes out at all.

What's a realistic timeframe for the first version of SPI-1005 to come out? 2022?

God damn, going to have to wait another two years for this stuff to come out, and that's assuming it gets FDA approval. Not sure if I can do that. I don't have $5k to throw at a shady Chinese lab.

I don't disagree, but I'm not going to invest my emotional health in a drug that won't be available for another one to two decades.

Ebselen is probably the only clinical stage drug I'm still keeping my eyes on.

Are there really zero labs out there selling Ebselen to consumers? I scoured the internet and found some websites but they either looked shady or were only selling to researchers. There are people here willing to shell out $10k just to see if it works and we still haven't managed to find a...

Give me all of that if it improves noxacusis.

Looks like Ebselen is the last man standing.

It doesn't seem like there are any studies on chronic tinnitus, but at least it has reduced or even cured acute tinnitus. Hopefully we can get further studies on both chronic tinnitus and hyperacusis, because it's still unclear whether or not the drug is merely preventative. But the over all...

Really hoping Sound Pharmaceuticals starts recruiting for Phase 3 soon. We’re in the home stretch. Maybe someone can reach out to them?

Well, it's been 2 days and that guy still hasn't responded. I should also clarify some things: * I don't know this person and I have no way of contacting them. * In fact, I'm rereading the messages from the DM and it's actually a friend of a friend of a guy who contacted me. So pretty far down...

I do not know this person, the stranger who contacted me would have to do that. But they still haven't responded to his initial questions which is weird.

Someone told me they had an online friend with loudness hyperacusis who ordered a 28 day supply of Ebselen and has already seen significant improvements after 3 days.

Definitely keep us updated. Everyone here is dying to know how Ebselen affects tinnitus. Do you happen to have hyperacusis and visual snow syndrome as well? Also, how much is the lab charging you if you don't mind me asking?

21 . 28 days at high dose 400 mg will set you back $2700. Which I guess is not too bad in the grand scheme of things if it could effectively cure hyperacusis, but that's not a guarantee.

That is insanely expensive though, about $1900 daily for the required 200 mg dosing — unless you have $13,300 to burn weekly. Science.bio was our best bet selling Ebselen for $60/g or just $12/day, but they don't plan on restocking any time soon. I've yet to find a source that isn't either...

Welp, fuck.

Less quality control for the science.bio one? They seem reputable.

This I could swing. I wonder if it's just as good as the more expensive stuff. I will put myself on the email least in any case. They're both above 98% purity. However, "Terms: This material is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical...

The clinical trial page says 200 mg Ebselen twice daily. Does that mean 2 doses of 100 mg or 2 doses of 200 mg? In any case it will set you back either $3,430 or double that for a one week course at low dosage--assuming the Alibaba lab is legit. If only I had that kind of money to burn.

What facilities test Ebselen? Also, what is the dosing for this stuff and how much would it wind up costing?

Can't you buy 1 g of Ebselen on Alibaba for $245? https://www.alibaba.com/product-detail/buy-98-powder-CAS-60940-34_60759100921.html?spm=a2700.galleryofferlist.normal_offer.d_title.3b4f3681Gtqpl1 Or is SPI-1005 different?

I am too dumb to understand anything in that article. Can I get the ELI5 version?

Is it really plausible that this drug comes to market in 2021? It has to complete Phase 3 and go through the data analysis, and then we have to wait for the FDA approval.

First the positive OTO-414 results and now this, what a week. Hopefully it can come to market sometime in 2021.

How much are they charging?

My thoughts are that if Ebselen works then we’d take it until FX-322 was publicly released.

That's it boys, I'm breaking into Sound Pharmaceuticals headquarters to get this drug.

Our main hope is that this can somehow help noxacusis.

Goddamn the wait is unbearable, the cures for noxacusis are sitting in a lab.

Yes, read the thread.

I hope noxacusis sufferers can get some slice of their life back on this drug.

Why would it have an effect on TMJ?

If this works, would it be something we took everyday or just after setbacks? I'm leaning on the daily side, that way you can prevent acoustic trauma because it's already in your system (as the studies indicate).

Yeah I would stock up on it if you're from out of the country, assuming it takes a while to get approved in other countries (and it assuming it works well for noxacusis).

No.

Misophonia is discomfort from particular sounds, like crunching or chewing. Do you mean phonophobia, the irrational fear of sound? That's psychological, this aims to treat inflammation in the inner ear. Or are you actually asking if this can help with noxacusis? Anyway, I imagine that's...

Imagine this, SPI-1005 allows noxacusis sufferers to live a relatively normal life (with some compromises, just not the level of no life we have right now) on a high enough dose. Yes I'm a dreamer. Fingers crossed.

Let's pray there are no more delays after this and it can come out before 2022.

Why :(

Yes, noxacusis. I hope it can help with pain if pain hyperacusis is associated with inflammation.

Where are your expectations at with regards to hyperacusis for this drug?

I think that would bode well for FX-322 if that were the case.

This is a good conversation, and I'm also curious what people's thoughts are with regards to the mid ear problems that come with hyperacusis. Things like TTTS/fluttering, trigeminal nerve pain, etc. It is unclear to me why cochlear damage would have such a profound effect on the middle ear as...

At the end of the day this is all just speculation on some forum. I appreciate the fact that they use scientific papers to back their assertions up, but when it comes down to it we simply don't know. FX-322 will probably be out before any study concluding whether the fibers are permanently...

I really hope this is not the case.

If you had to guess, when’s the soonest we could see SPI-1005 available for off-label use? I know it’s being fast-tracked because of COVID-19, but like others have said I’m worried it will be for COVID-19 only initially.

Inflammation isn't causing the problem but it's a byproduct of it, so reducing it should help a lot even if it's just a bandaid until regenerative medicine.

I think there is a good chance regenerative medicine will be hugely helpful but that we'll wind up using SPI-1005 and XEN-496 in the short term.

Vistagen also has a non-addictive GABA drug for neuropathic pain in the pipeline called AV-101 that looks quite promising. Basically Lyrica with way fewer side effects. It's being fast-tracked.

What is making the inner ear chronically inflamed for someone with hyperacusis?

I am most excited by SPI-1005 at present because it seems likely to help with hyperacusis and is coming to market very soon.

The optimism seems founded if the science checks out. Of course we will have to wait and see, hopefully sometime in 2021.

I’m trying to fully grasp in what ways SPI-1005 would be beneficial for noxacusis sufferers and how that would manifest into our everyday lives. It will essentially eliminate inflammation so that means no more pain unless we re-aggravate it? And what are the implications of that in our day to...

Noxacusis sufferers are screwed once the pandemic ends and we have to go back to school and work in person.

So there is a potential chance of getting this as soon as the end of 2020? That would be amazing.

Of course we will need to treat cochlear damage to fully resolve the issue, but if this can give us a good chunk of our lives back then it will be enough to cope until better regenerative treatments. Currently most moderate-severe noxacusis sufferers are housebound.

I definitely wouldn't mind taking this everyday for the rest of my life to prevent setbacks. Hopefully it's not too expsnsive.

Do you think that SPI-1005 could instantly put us in the remission phase? Not to say that it can’t be reaggrivated, but so as long as we’re careful around noise then we can live relatively normal lives barring acoustic trauma outside of our control.

So from what I've come to understand SPI-1005 proliferates the number of support cells. Is this good or bad for stuff like FX-322? And what is a support cell's function?