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I'm sure it's just like anything else. You build a tolerance to it. Long term studies will be needed to see what the effectiveness over a period of time is.

I think it should be noted that the study @stelar is referring to was based on NMDA treatment of tinnitus, which is a very different mode of action from MDMA.

Ketamine is a controlled substance and AM-101 is basically a stronger version of the drug. If a drug can be shown to have useful effects while minimizing side effects (either through dosing or through finding a chemical derivative that still has the desired effect) it can easily sail through...