Neuronal Heterogeneity and Stereotyped Connectivity in the Auditory Afferent System

[Johan_L]

This was mentioned on the evening news in Sweden today with the headline "New hope for treating tinnitus". In short, the researchers believe they are paving the way for curing tinnitus with gene therapy.

It's a pretty long text... any comments?
https://www.nature.com/articles/s41467-018-06033-3#Abs1

 

[JohnAdams]

the researchers believe they are paving the way for curing tinnitus with gene therapy.

Me too. Not kidding.

 

[AmericanJosh]

This was mentioned on the evening news in Sweden today with the headline "New hope for treating tinnitus". In short, the researchers believe they are paving the way for curing tinnitus with gene therapy.

It's a pretty long text... any comments?
https://www.nature.com/articles/s41467-018-06033-3#Abs1

That's the headline for nearly every research article that mentions tinnitus or hyperacusis and yet we are without a cure or effective treatment.

The study mentions this critical element: "future studies will be needed to also identify the dedicated output neurons and associated ascending circuits needed to process centrally the peripheral information encoded by each individual SG neuron type."

While we are certainly heading in the right direction, with more attention to research, there seem to be so many possible ways to attempt to explain the issues and how to address tinnitus. I am hopeful that one day we will get there, but based on the pace of scientific study and analysis, I would not expect on tomorrow...or next year...or...

 

[Contrast]

Charles Liberman's paper gives us hope
https://f1000research.com/articles/6-927/v1

 

[JohnAdams]

View attachment 22057
Charles Liberman's paper gives us hope
https://f1000research.com/articles/6-927/v1

Neurotrophins are available as supplements.

 

[Contrast]

Neurotrophins are available as supplements.

how are you going to get them into your cochlea?

 

[JohnAdams]

Neurotrophins are available as supplements.

View attachment 22057
Charles Liberman's paper gives us hope
https://f1000research.com/articles/6-927/v1

Looks like it is Vitamin A.
https://www.ncbi.nlm.nih.gov/m/pubmed/18782483/

 

[JohnAdams]

how are you going to get them into your cochlea?

Blood stream.

The increase in neural growth factor was observed in the rodents' brains, from their diets. If it can get in the brain it will get in the endolymph.

 

[AmericanJosh]

Blood stream.

The increase in neural growth factor was observed in the rodents' brains, from their diets. If it can get in the brain it will get in the endolymph.

Tinnitus gene therapy in it's infancy:https://www.google.com/url?sa=t&sou...FjAPegQICRAB&usg=AOvVaw3Pto6JrpT4BlRxGCZJpUPj

 

[JohnAdams]

Tinnitus gene therapy in it's infancy:https://www.google.com/url?sa=t&sou...FjAPegQICRAB&usg=AOvVaw3Pto6JrpT4BlRxGCZJpUPj

If tinnitus was caused from noise induced hearing loss, loss of cochlear hair cells, then restoring the hair cells has and WILL restore hearing and then the tinnitus should go away. But there are seemingly many causes of tinnitus and restoring hearing will surely not cure them all.

 

[AmericanJosh]

If tinnitus was caused from noise induced hearing loss, loss of cochlear hair cells, then restoring the hair cells has and WILL restore hearing and then the tinnitus should go away. But there are seemingly many causes of tinnitus and restoring hearing will surely not cure them all.

That makes sense but when have they restored human hair cells? I dont think that's happened yet.

 

[JohnAdams]

That makes sense but when have they restored human hair cells? I dont think that's happened yet.

Some man had a brain tumor and donated his cochlea when they had to cut it out to get the brain tumor. They tested the notch inhibition on it and it worked, unfortunately not as well as the rodents. That being said it was also not in his body anymore, which must he taken into account. The shock of being explanted probably affected it.

 

[Contrast]

That makes sense but when have they restored human hair cells? I dont think that's happened yet.

it's already happened in other mammals including primates.
(probably some humans in Novartis and Frequency-tx's early trials)

Tinnitus gene therapy in it's infancy:https://www.google.com/url?sa=t&sou...FjAPegQICRAB&usg=AOvVaw3Pto6JrpT4BlRxGCZJpUPj

this is meant to identify the subtypes of tinnitus from a neurological approach (what region of the brain tinnitus is established in, who is more at risk gentically" I don't think it's going to be a problem when reversing SNHL helps the majority of tinnitus patients.

 

[Contrast]

There are researchers that treat tinnitus as a completely neurological issue, they are not ignoring the concept of repairing the inner ear, they just have a separate way of going about the problem which I am 100% in support of.

https://www.tinnitustalk.com/thread...and-body-stimulation.28022/page-9#post-359291

https://www.tinnitustalk.com/threads/new-university-of-michigan-tinnitus-discovery-—-signal-timing.2805/

From what I understand, both of these devices target tinnitus from a strictly neurological approach and they both have success. The problem is tinnitus research is so disorganized and there are shills in the community that parrot nobody knows anything "Pawel Jastreboff"

20 years ago scientist weren't talking about stimulating the Dorsal Cochlear Nucleus to disrupt the tinnitus activity, regenerating cochlear hair cells reconnecting hair cells with the audiotory nerve and the genesis of ribbon synapses, or increasing GABA levels to reduce tinnitus. Nothing was going on, NOTHING but Pawel Jastreboff shilling his dogma

now we actually have a chance, I'm not kidding when I say this pretending me to be pessimistic when there are reasons not to be actually does hold back research and keeps the Pawel Jastreboff's dogma alive.

 

[Contrast]

Some man had a brain tumor and donated his cochlea when they had to cut it out to get the brain tumor. They tested the notch inhibition on it and it worked, unfortunately not as well as the rodents. That being said it was also not in his body anymore, which must he taken into account. The shock of being explanted probably affected it.

show me the paper

 

[Contrast]

Some man had a brain tumor and donated his cochlea when they had to cut it out to get the brain tumor. They tested the notch inhibition on it and it worked, unfortunately not as well as the rodents. That being said it was also not in his body anymore, which must he taken into account. The shock of being explanted probably affected it.

All i need is probably 15 db of hearing back in my upper frequencies tbh

 

[Spiral]

There are researchers that treat tinnitus as a completely neurological issue, they are not ignoring the concept of repairing the inner ear, they just have a separate way of going about the problem which I am 100% in support of.

https://www.tinnitustalk.com/thread...and-body-stimulation.28022/page-9#post-359291

https://www.tinnitustalk.com/threads/new-university-of-michigan-tinnitus-discovery-—-signal-timing.2805/

From what I understand, both of these devices target tinnitus from a strictly neurological approach and they both have success.

Treating the symptoms are only a temporary solution. Treating the root cause will be the best long-term solution (e.g., regenerating hair cells/nerve synapses).

Imagine getting headaches but medication only helping a little bit. Taking medication every time you have a headache just isn't practical. Diving into the root cause might determine that you need glasses or an updated prescription. Boom, headaches are gone.

Some relief is great but a cure is the best thing to shoot for, IMO.