Safety and Efficacy of Intratympanic Application of Dexamethasone Via Catheter in Patients With SHL

[Tinnitus Talk]

Tinnitus Talk submitted a new resource:

Safety and Efficacy of Intratympanic Application of Dexamethasone Via Catheter in Patients With SHL. (version 1.0) - To determine safety and efficacy of the application of Dexamethasone for Sudden Hearing Loss.

The purpose of this study is to evaluate the efficacy and safety of an intratympanic continuous two-week application of dexamethasone compared to placebo using a temporarily implanted catheter in patients with severe to profound sudden sensorineural hearing loss and insufficient recovery after initial systemic prednisolone therapy.


Enrollment: 23
Study Start Date: October 2003
Study Completion Date: July 2007
Primary Completion Date: July 2006 (Final data collection date for primary outcome...

Read more about this resource...

 

[Dhaval]

Hi guys

There is some logic that says this works for recent victims of tinnitus and snhl. Snyder ideas....has any 1 undergone this.......please share

Thanks
Dhaval

 

[physics13]

I'm desperately taking 80mg/prednisone and it is helping. I'm considering the tympanic injections to regain speech comprehension so that I can work as a professor

 

[sakrt]

I knew of one patient four years ago, whom Drs. classified as one with "SNHL", but functioned fine in life wearing hearing-aids. However, he had T. He had this procedure in desperation, ended up in the hospital for weeks with worse debilitating issues, including spinning vertigo to the mix. Irony is, this arrangement is often prescribed for patients w/ vertigo symptoms.
He is now completely disabled with vestibular issues, completely DEAF; cannot wear hearing-aids anymore.
Great experiment though!
Conclusion: Need I say more?

 

[physics13]

Dear Kasart,
Thanks so much!!! I think I will not do the injections then.
Yes you have to be very careful about these pubmed studies since the researchers often have no regard for what happens to patients and the horrible damage you can get from experimental procedures.

perhaps a better option is a prednisone spray or prednisone drops. but you must be extremely careful that you do not get the drops with OTOTOXIC antibiotics like tobramycin or gentamicin (these should be banned)

 

[physics13]

is this Intratympanic treatment where they actually cut your eardrum with a needle? is there a treatment where they just spray steroid into your ear.
I just want to recover my speech comprehension so I can work and talk to people

 

[Stink]

is this Intratympanic treatment where they actually cut your eardrum with a needle? is there a treatment where they just spray steroid into your ear.
I just want to recover my speech comprehension so I can work and talk to people

Can you read? It reads intratympanic in the title!!!

Intratympanic = to administer drugs locally through intratympanic (i.t.) injection to maximize efficacy and minimize systemic side effects.

Spray won't reach the middle ear!!! Sprays are useless. How would it get through tympanic membrane??

 

[physics13]

I wasn't sure if intra or inter meant puncturing the delicate ear drum. But you see that patients have been terribly damaged by this procedure and unable to use hearing aids because of it. Please think rationally about this, I think a spray could possibly help

 

[physics13]

I completely agree with the rational view of Kasart here. It is definitely not worth the risk of having vertigo and deafness when you can function with hearing aids.
I went to Mt. Sinai NYEE and the resident told me that they never do tympanic injections in my case

 

[physics13]

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639951/
I don't know what to do, this study notes 70% improvement with tympanic injections, but it still may not be safe...

 

[sakrt]

ncbi.nlm.nih.gov/ are mainly abstracts/hypotheses with short-term small clinical trials which often end up with positive conclusions- noticed? e.g 70% success rate! Are ANY ever mention - this approach is not recommended for... or this was experimented on 10 patients (out of millions) in society who have no other vestibular symptoms etc. Negative/debatable abstracts are NOT published. Best way to get unbiased info. (like learning a new language) is to actually get it from people in the -real- world if you're able, such as this forum.

One has to educate themselves these days and get help from others. It's not helpful when one replies in a condescending manner to those who asks questions, when the forum/threads are for this reason!- Awareness & assistance. Displaying behavior as many "expert" arrogant Drs who have no people skills - We don't need this attitude here too.
Physics13: Transtympanic injections are painful - they are injected through the tympanic membrane (eardrum) by needle filing the middle ear w/ steroids or other drugs for short-term relief. Usually performed on Meniere patients at the early stage. Many state on other forums as well as people I know, that they did not work for them. A Dr. wanted to experiment with me (had no Meneire symptoms), but he wanted to do it anyway w/o any work-up - I declined). Learned later from another Otoneuro. that this would have worsened my condition by possibly adding Vertigo. Vertigo is a horrible malady to have.

 

[physics13]

Yes these studies are really dangerous and experimental and they never list the terrible damage and results possible from larger groups of patients. Who knows how many people would actually go deaf or have vertigo or even die from these experiments if it was a large group of patients. I took ampicillin based on a study I read and it destroyed my hearing and NOONE listed the terrible DAMAGE and DEAFNESS it could cause

 

[cullenbohannon]

@physics13 I think the study referred to in this thread is different from the the standard intra tympanic injections. This study talks about a continuous application for two weeks.

I had injections as part of the am 101 trial, they put a tiny incision in the ear drum which was did not hurt. The third day was a little bit uncomfortable but not painful. The hole in my eardrum healed quickly every time which is why i needed a new cut every time.

Thought i would share with my experience.

 

[physics13]

thanks for posting this. but it still seems like a terrible risk since people have gone deaf and gotten permanent vertigo from it according to the poster on here

I've started to try dexamethasone oral pills instead but don't know what is a good and safe dose, maybe 5mg is really extremely high? but I took about 12.5mg with 30mg of prednisone and I still this morning couldn't understand the cashier and order food at Mcdonalds

 

[Brianna]

I knew of one patient four years ago, whom Drs. classified as one with "SNHL", but functioned fine in life wearing hearing-aids. However, he had T. He had this procedure in desperation, ended up in the hospital for weeks with worse debilitating issues, including spinning vertigo to the mix. Irony is, this arrangement is often prescribed for patients w/ vertigo symptoms.
He is now completely disabled with vestibular issues, completely DEAF; cannot wear hearing-aids anymore.
Great experiment though!
Conclusion: Need I say more?

No, you need not write more. I saw this thread, the topic and went in search of you . physics13 - be careful with what you wish for. sakrt has his/her own torture data to go along with what has been stated. I'm a counterpart (huh, k?) and strongly back up most his/her statements. I am deaf. Don't muck with your ears or if you muck with them, be prepared for possible negative consequences. I know desperation but be careful. Also, physics13, don't believe everything you read on the internet. The world is about marketing and selling and not correcting lies and not posting truths.

 

[sakrt]

I had injections as part of the am 101 trial, they put a tiny incision in the ear drum which was did not hurt. The third day was a little bit uncomfortable but not painful. The hole in my eardrum healed quickly every time which is why i needed a new cut every time.

Incisions in the tympanic membrane? that's a new one. You stated "...every time". How often was it performed?
Do you recall the chemical they injected and did it resolve your T ?

 

[cullenbohannon]

Incisions in the tympanic membrane? that's a new one. You stated "...every time". How often was it performed?
Do you recall the chemical they injected and did it resolve your T ?

Im not sure how incision qualifies "as a new one".
The chemical is esketamine I believe.

I had it three times over three days. The AM101 thread has more then a few people who underwent the procedure and none have had the world ending side effects mentioned in the thread. Unfortunately i did not get any relief but i may have gotten the placebo though.

also in this link it has side effects and it seems to be a safe procedure.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966923/

this was specifically for am 101


@physics13 Im not sure one person who says someone had a bad effect from injections means that the procedure is dangerous. Im not trying to convince you either way but trying to give you some perspective. There was a link posted to me by @Markku in the AM101 thread because i was afraid of going through with the injections which i cant find but if i do i can post it, but it showed that the injections are quite safe.

 

[physics13]

No Kasart is right, you can end up deaf and with vertigo which would be horrific. I already have vertigo after reading internet forums and pubmed studies.
Please note the pubmed researchers never write about the horrific deaths and damages that their experiments can cause often and they aren't proven to work which is why they aren't clinical practice right?
doctors are human, often they go into medicine because they can't make it in mathematics or physics and want money. even the greatest mathematician cannot make a pubmed study work

 

[cullenbohannon]

@physics13 As long your comfortable with you decision thats all that matters. I really hope things get better for you soon. The below is not me trying to debate you, i just thought you might offer some clarification.

Please note the pubmed researchers never write about the horrific deaths and damages that their experiments can cause often and they aren't proven to work which is why they aren't clinical practice right?

As far as im aware, Pubmed are not the ones who do the actual research maybe they do in some instances but not the majority. I believe they are a database that relays or reviews information for different scientific journals. Do you mean that they leave out the research that shows negative side effects, or completely disregard studies done that show negative side effects? And if yes to either of this, is there a reason for it, any articles you can point me to that supports this? Thanks in advance.

 

[sakrt]

Im not sure how incision qualifies "as a new one".
The chemical is esketamine I believe.

Thanks for the info. Usually "incisions" through tympanic membranes are performed for more serious surgery to access the middle ear or drain fluid. Injection of chemicals are often done by hypodermic needles. Interestingly, they did incisions instead...did they ever state why? Sounds like tubes were put in for the experiment. I'm sorry it wasn't productive.
Fortunately, there are new agencies monitoring and providing society the corruption behind closed doors between FDA and big pharma. companies. This link may provide a better understanding of how things work between them (within USA) and how published research are now becoming questionable. Check out the whole site.
http://www.anh-usa.org/big-pharma-and-fda-a-marriage-not-made-in-heaven/#more-12525
http://www.anh-usa.org/once-again-the-fda-deliberately-keeps-us-in-the-dark-about-bad-science/

 

[cullenbohannon]

Thanks for the info. Usually "incisions" through tympanic membranes are performed for more serious surgery to access the middle ear or drain fluid. Injection of chemicals are often done by hypodermic needles. Interestingly, they did incisions instead...did they ever state why?

They just said this is how the procedure is, the did the incision, the ents words, and then injected the am101 through the hole. Never actually explained why they did it this way from what i remember.

I'm sorry it wasn't productive.

Thanks @sakrt, I will admit i had high hoped for the trial but i am doing better then i was anyway.

Thanks for the links i will look into them as soon as i have a chance.

 

[Frédéric]

This clinical trial does not appear anymore on clinical trials registry platforms. But I did a search on the net with the title "Safety and Efficacy of Intratympanic Application of Dexamethasone Via Catheter in Patients With SHL" and I found this link, which is a systematic review:
http://www.sciencedirect.com/science/article/pii/S1808869415001895

PDF file attached.