Recent content by Silvio Sabo

I think most who consider tinnitus to be disconnected from hearing loss use an audiogram and think "I have no hearing loss, but I have tinnitus. Therefore tinnitus is not connected to hearing loss". However it's not as simple as that. Audiograms are really blunt tools and hearing loss comes in...

Calcium ion channels are also involved in the accrue phase. If I remember correctly release of calcium is one of the steps in the cascade of things leading to hair cell death after loud noise exposure.

Anti-inflammatory makes me believe it belongs to the same category as AM-101/Keyzilen, meaning it's geared towards treating tinnitus at the earliest stage (the so called acute phase).

If you listen to the Tinnitus Talk Podcast about Frequency Therapeutics with their representative Carl LeBel, he speaks about this. At Frequency they think that so called hidden hearing loss is actually hearing loss at the high frequencies that a normal hearing test doesn't test but that it...

Agreed. I don't use the dryers either. If there are no paper towels I just give my hands a quick shake after washing and then just let them air dry. It's not like your hands are going to stay wet for hours. They're dry within two minutes. But then again even if the dryers are loud you aren't...

We don't know. We can only speculate. But I believe I've read somewhere that someone from Frequency Therapeutics said that they had indications that this is the case. That nerves do grow out and attach to the new hair cells.

What about long term use? In the trials they only did the treatment for a number of weeks. But we still don't know what would happen if someone were to do the treatment continuously for, let's say 2 years!? If I recall correctly @kelpiemsp talked about a cumulative effect on his treatment in...

True but still important. To be honest there is nothing in the area of treatment that I could read about in his research. So talking about anything being marketed at all as of now is just dreaming. But nonetheless the research into the root cause of tinnitus is very important and we should not...

I've never advocated TRT. I have made my stance on TRT vocal several times on this forum. I find it to be a complete waste of time and money.

This is simply not true. Hearing usually deteriorates over time. Listening to headphones at higher volumes for hours over a longer period will have a profoundly negative effect on your hearing. This has nothing to do with what most people do or don't do. If most people jumped off of buildings it...

Listening to music using headphones can get you up over 100 dB, depending on headphones and HiFi equipment can definitely get you over 100 dB, which is more than enough to do serious damage.

Not JUST 2. At least 2. Multiple implies more than 1, which is AT LEAST 2. But there could be more.

Well, the US were leading in the field at the time so cutting the funding killed and/or slowed down progress. Which set the field back a number of years.

You can read it in a press release note on Frequancy Therapeutics home page. http://www.frequencytx.com/news-events/news-events-press-release-04-09-2019.php "In the Phase 1/2 study, FX-322 was safe and well tolerated following a single intratympanic injection with no serious adverse events. In...

Well, maybe. More than one person had some improvement in hearing. But we don't know if that is due to new cells, new cells connecting to existing nerve, new cells AND a new nerve growth or just a restoration of the ribbon synapse between existing cells and existing nerves. And we won't know...