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Back in 2013 when my tinnitus journey began, you could not visit any tinnitus community without hearing about AM-101. At some point I started...
The rule of thumb I apply is to wear earplugs whenever I leave the house. It's only a matter of time before someone honks their car horn while you...
Seems like you have done a lot. The only things I can add to the list is to be consistent with ear protection and to have a read of the...
Seems like someone has thrown a curse at the inner ear pharma field. First Auris Medical, then Otonomy, and now Frequency Therapeutics. That's +10...
Well, the efficacy of OTO-313 was evaluated using the TFI score (which is fully subjective). OTO-413 is evaluated using speech-in-noise testing...
Perhaps give Taurine, NAC, Creatine, Magnesium and Pycnogenol a go. Protect your ears whenever outside in an environment you can't control. You...
Pretty incredible that a full decade of clinical trials still hasn't yielded any tangible progress. That's pretty much all I have to say. Best...
No, no impact on tinnitus in my case. Got the Pfizer shot (x 2) five weeks apart. However, this article looks into a three-patient case study...
This thread was created more than five years ago (by yours truly) with no developments since then (as far as I know). However, earlier this year,...
Hmmmm... wrong... both the FDA and the EMA say that a 10 dB improvement is clinically significant: "With regard to Sonsuvi , the FDA and EMA have...
It doesn't matter that those deficits are present – they will be omnipresent and will show up in both the before and after scenario thereby...
The reason that the interim analysis showed the study failed (even though WR scores improved) is that when WR scores (also) improved in the...
The example you provide compares two different pieces of equipment (it is quite obvious from the readout that the testing was done in different...
I agree: any person in their right mind wouldn't go through all the trouble it takes to set up a biotech just to be a fraud. Fraud in business...
I wouldn't worry about it, but also not likely to help. For supplements, try Creatine, Pycnogenol, Turmeric, and Magnesium. Perhaps also NAC,...
I had no idea what 3-MMC was until you mentioned it. Having looked it up, I understand that the drug acts as a dopamine stimulant, and, anything...
Perhaps look into supplements like Magnesium, NAC, Pycnogenol, and Zinc. Do an Internet search of the various terms in combination with "pubmed"...
Usually, I always lean towards noise exposure as a culprit when folks tell their story on Tinnitus Talk. But, in your case, perhaps consider the...
A trip through an MRI scanner can take your existing tinnitus to a whole new level. Be sure it's what you want.
At 3:04 (in the video) the audiologist begins to dissect the second difference between the Wenzel study and the clinical trial related to OTO-313....
If he firmly believes in his message, then it's probably a consequence of his self-delusional traits. Suppose the advice @Michael Leigh dispenses...
Well done. This appears to be an important piece of advocacy that no doubt took a lot of hard work and dedication. Good to see some concrete...
I am surprised @Michael Leigh hasn't already left his trademark comment indicating "reactive tinnitus" is not a thing, but something made up on...
Newbies have a tendency to over-complicate the plot and search every avenue for answers: however, more often than not, noise exposure is the...
Well, there is a difference between the peripheral and the central nervous system. Also scar tissue plays a role. Some nerves do heal, and...
Indeed.
When it comes to tinnitus, there is essentially no difference between a good and a less regarded ENT. They are all equally unable to help. And...
Well... my input: title is misleading (i.e. "Tinnitus Retraining Therapy Is Ineffective, Latest Study Finds"). The study didn't conclude that TRT...
Well... given that the average donation per tinnitus sufferer (not to mention general engagement) is way less than for other medical conditions, I...
Examine your patient history and you will eventually come to a conclusion containing substance that cannot be revealed by objective tests. Any and...
See a lawyer as early on as possible while the incident is still fresh and witnesses can be asked to make a statement. The "organization" is not...
Noted. But those criteria above, do not relate to chronicity or severity (which was what I was addressing; I guess, I could have been more clear...
The Otonomy team themselves experienced the difficulties related to conducting a clinical trial based on subjective assessments (as was the case...
It's been a while since I have shared any pharma news here on the forum, but today, Otonomy held its Q1 2019 conference call on the results for...
An article by the Daily Mail has shed light on gender differences when it comes to those suffering from severe tinnitus. A Swedish survey – which...
Even one concert can cause tinnitus, hyperacusis, and hearing loss. Permanently. If you go to concerts (regularly) and listen to all genres of...
@just1morething – No need for drama: the scenario with the needle you describe is already included in the price (except it contains growth factors...
@SilentWay – it's almost six years ago I did my first treatment. I therefore recommend you rely on your own insights at this point (re: options,...
No.
Indeed, the same could happen to FX-322. But... if it did, it would be for entirely different reasons. AM-101 "failed" (as in an "inability to...
The trouble with some agents leading to ototoxicity is retention in the cochlea – here are two examples (concerning aminoglycosides and...
I think you can extend your observations to other variants of the Internet, like... forums – incl. tinnitus forums! Certainly, TinnitusTalk has a...
"Incredibly unlikely" (as an event) or "incredibly unlikely" (as a cause)? In the case of a known acoustic trauma, ear fullness is an expected...
Indeed: both you and your ENT have some reading to do...!
For once, I agree with everything you say. Except the last sentence...
Indeed. However, dichotomies exist not only in relation to the age-old debate about protecting or not protecting (sounds almost like sex...
Why would you have been using white noise generators for 23 years... ...if you are already fully habituated??? Makes no sense. Tell me @Michael...
Thanks for your... ahem... informative essay. I suppose it is possible to surmise many things about you. However, one particular point I feel...
You trust(?) the judgement of a borderline senile member who spends his entire life – day and night – on TinnitusTalk claiming he is habituated...
For more than one reason, I am indifferent as to which candidate receives the money. As I see it, the best outcome that could arise from this...
Given that as much as 90% of tinnitus cases are noise-induced, I am not sure what role a physical therapist might have in providing a resolution....
That percentage split seems in line with the average online tinnitus community if you ask me...
Yes... I am beginning to see how the business model might work: you listen to the awful soundtrack and when you are done with the file and take...
Given the degree of your senility, the degree of your inferiority complex, as well as your apocalyptic display of self-deceit, the very last thing...
Well... I guess your own subsequent line explains everything doesn't it...?
Evolution only plays a part when a medical condition prevents an individual from having children (e.g. because of premature death). Getting rid of...
@Michael Leigh – I have not read your lengthy essay as what you have to say is at best unimportant, but most often just plain annoying. However, I...
Meanwhile at the NHS as we approach the end of the year... [ATTACH]
Well... I am not up-to-date, but unless something has changed significantly, the legend is as follows: blue = normal member bold blue = physician...
Very common complaint. The TRI flowchart remains the best resource there is:...