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There is no mystery as to why not all noise-induced hearing loss leads to tinnitus. First of all, let's think about noise. Noise exposure has...
I'm sorry that I can't be of any help with this question.
Thanks, I would enjoy the chance to be a part of that. I take a lot of inspiration from the Tinnitus Talk community. Hi @Nick47, yes, there is a...
My compliments on such a polished and thorough resource. @Hazel, my feedback is that the author's treatment of the Central Gain Model contains a...
Cumin oil and unipolar brush cells have NOTHING to do with one another. I’m suggesting that discussions about unipolar brush cells are interesting...
Tinnitus is measured through a highly subjective self report. Any type of clinical study that uses self-report instead of an objective measure...
It’s not useless, it’s basic science. It’s a perfectly wonderful study about how neurons are affected by a neurotransmitter that is not often...
Snake oil is another way of saying a bogus therapy. I find it frustrating when people who use “Dr” in their title, waltz into a discussion in this...
This study has very little to say about serotonin and tinnitus. They applied non-physiologic concentrations of serotonergic agonist to slices of...
That utterly and completely misses the point of this article, doc. They are describing a structural signature for a potential key neuronal...
Haha. Oh wow, that is embarrassing. My poor, porous memory...
Hi @linearb, we are totally on the same page. What makes the treatment condition special (i.e., different than the control group) is the specific...
Hey oxytocin fans, I'm chiming into this thread a bit late, with apologies if these points have already been raised. Oxytocin is a peptide that...
If I post that information I will put their placebo control at risk, potentially excluding people on this forum from participating in their trial....
The idea is to deliver a tactile stimulus to the jaw at a specific time interval relative to moderate sound stimulation. Their hypothesis is that...
Like Aaron said, it's a poster abstract. No peer review. I think non-invasive direct brain stimulation has potential, though it's hard to control...
That's not how tinnitus works. Damage to the ear has virtually immediate effects on the brain. The perception of tinnitus -whether acute or...
Otonomy is a hammer looking for a nail. They have a bunch of patents on this method for cochlear drug delivery and now they are fishing for...
1) no control, 2) effects were temporary, 3) doesn't really make sense.
This is the only study I could find - Eur Arch Otorhinolaryngol. 2010 May;267(5):691-9. doi: 10.1007/s00405-009-1126-1. Epub 2009 Oct 22. Effects...
@EatMoTacos Hey @EatMoTacos, no, sorry, the point of that last discussion with @Steve drifted a little bit from the topic of masking and...
@Steve, this paper came up with a clever way to nest a low-frequency binaural rhythm (i.e. dichotic) in the theta/alpha range inside a higher...
What I can say for sure is that neurons throughout the auditory pathways in the brain will synchronize to binaural beats in the beta, alpha, theta...
By the way, this is the hottest thing in DBS right now - http://news.mit.edu/2017/noninvasive-method-deep-brain-stimulation-0601. Could be...
Do you mean Josef R? (Rauschecker). Perhaps you could point me towards your source. It sounds plausible, but I would like to read instead of just...
As a field, we need to test interventions and not just fiddle around, but we also need good objective markers of the pathophysiology underlying...
It is like trying to solve the puzzle on Wheel of Fortune with only one or two letters revealed. The parameter space for how/where/when to...
I do. I think they have real potential, though I don't think we have a strong, hypothesis-driven theoretical framework for how to use them in the...
To your last point, I do think some of the potassium channel modulators are interesting and there are some compounds in that area that we have...
Regardless, the ear is just the trigger. The pathology that gives rise to tinnitus is in the brain.
Protecting an ear from imminent damage - yes. Repairing an ear that was very recently damaged - maybe. Restoring function to an ear with a genetic...
Little confidence for adult ears that have long-standing, widespread damage. No, no laboratory or company that I know of is close to regenerating...
Logically, it seems improbable to me that this will be the organ system where we see a quantum leap forward in regenerative therapies. I'm not...
The inner ear is among the most complex, intricate and inaccessible organ in our body that is under-studied and under-funded.
As for inner ear therapies - most (but not all) people with tinnitus have widespread, chronic cellular degeneration in the inner ear. There is no...
I just don't believe in "magic bullet" theapries for solving complex disorders.
Paulmanlike, check out Pg. 90 of that thread. In a nutshell, tinnitus is a complex, distributed neurological disorder arising from a brain...
Vermillion, unfortunately, yes. I have a high-frequency tonal tinnitus. It reminds me everyday about the urgency of finding the mechanism and...
Thanks, vermillion. Yes, we have funding from the NIH as well as private philanthropy.
Paulmanlike, I have stated my (fairly unpopular) opinion on the potential near-term value of hair cell regeneration therapies for tinnitus clear...
Have you considered moving the speakers or the piano to the back of the room so that they are closer to the students but farther from your ears?...
Director of a tinnitus research laboratory
Hi Samir, you'll have to give me a little more context for what you mean by "binaural fusion". The inputs from the two ear are fused at a very...
https://motherboard.vice.com/en_us/article/mbeqw8/should-you-pull-a-baby-driver-and-use-music-to-drown-out-your-tinnitus
Massachusetts Eye and Ear just received a large award from the NIH to develop new functional tests to reveal the pathology underlying "hidden...
I know, it seems crazy. The root of the problem comes down to the sociology of medicine. Tinnitus and hidden hearing loss fall at the intersection...
Well, let's not get too dismayed about the sum total of what we don't know. I think we do know what constitutes normal, healthy hearing. If...
Most people in the central gain camp think it is a heterosynaptic plasticity process. That means that all synaptic inputs impinging on a neuron...
I'm less familiar with the relationship you described. Most people with high-frequency hearing loss experience the tinnitus pitch to be slightly...
To clarify, think of central gain as a u-shaped curve. -Prolonged periods in very quiet environments are associated with low levels of...
Nice catch. Yes, this is one implication of studies that would seek to dial down the central gain. Ideally, the "knob" could be turned down just...
Maybe you will indulge me in a little experiment. I was wondering if you could play scales (or another melody) where all/most of the notes are...
Yes, there are hundreds of studies in animal models that look at 'plasticity' in the tonotopic arrangement of sound frequencies that accompany...
No, this is anecdotal. It has been relayed to me by clinicians and patients. There may be research papers on it but I cannot name them. The...
Yes, I agree with you 100%. Thanks for bringing this up. In fact, masking therapies are probably the most reliable form of tinnitus suppression....
For someone with notched or steeply sloping hearing loss, signals essential for communication (e.g., speech reception) might overlap with regions...
The mechanism is tied into the central gain theory of tinnitus. The typical explanation is that most tinnitus is triggered by pathology in the...
TinnitusPro is a piece of software that let's you listen to music of your choosing that is passed through a notch filter. To be fair, their...
Yes, you are absolutely right about that. My recollection from seeing a talk a few months ago was that the pre-clinical data were strong enough to...
Not sure if this was brought up, but this is a paper from a very productive, reputable lab that is not at Mass. Eye and Ear that casts some doubt...
