HomeoHebbian
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Sep 17, 2017 at 4:53 PM
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HomeoHebbian

Member, Male, from United States

Director of a tinnitus research laboratory Aug 29, 2017

HomeoHebbian was last seen:
Sep 17, 2017 at 4:53 PM
    1. Paulmanlike
      Paulmanlike
      Hi, what are your views on the potential of NMDA receptor antagonist gacyclidine in the treatment of tinnitus? I see Otonomy are evaluating this drug in a phase 2, do you think that this may even treat chronic as well as acute tinnitus?
      1. HomeoHebbian
        HomeoHebbian
        This is the only study I could find - Eur Arch Otorhinolaryngol. 2010 May;267(5):691-9. doi: 10.1007/s00405-009-1126-1. Epub 2009 Oct 22.
        Effects of extracochlear gacyclidine perfusion on tinnitus in humans: a case series.

        Wenzel GI1, Warnecke A, Stöver T, Lenarz T.
        Sep 3, 2017
      2. HomeoHebbian
        HomeoHebbian
        1) no control, 2) effects were temporary, 3) doesn't really make sense.
        Sep 3, 2017
      3. HomeoHebbian
        HomeoHebbian
        Otonomy is a hammer looking for a nail. They have a bunch of patents on this method for cochlear drug delivery and now they are fishing for possibles uses.
        Sep 3, 2017
        Paulmanlike likes this.
    2. Fabrikat
      Fabrikat
      Do you believe treatments such as deep brain stimulation or rTMS, offer any prospect of success?
      1. View previous comments...
      2. Paulmanlike
        Paulmanlike
        It seems clear we are a long way off to defining protocols to use these methods rTMS and DBS effectively.
        Aug 30, 2017
      3. HomeoHebbian
        HomeoHebbian
        It is like trying to solve the puzzle on Wheel of Fortune with only one or two letters revealed. The parameter space for how/where/when to stimulate using rTMS and DBS is vast and we have very few guiding principles in place for the appropriate use of these technologies for tinnitus, specifically.
        Aug 31, 2017
        Paulmanlike likes this.
      4. HomeoHebbian
        HomeoHebbian
        As a field, we need to test interventions and not just fiddle around, but we also need good objective markers of the pathophysiology underlying tinnitus. At present, we don't know what it is we are trying to erase, reverse, correct etc. so, unfortunately, these efforts are shots in the dark for the time being.
        Aug 31, 2017
        Paulmanlike likes this.
    3. HomeoHebbian
      HomeoHebbian
      Director of a tinnitus research laboratory
      1. View previous comments...
      2. HomeoHebbian
        HomeoHebbian
        Do you mean Josef R? (Rauschecker). Perhaps you could point me towards your source. It sounds plausible, but I would like to read instead of just firing off a quick answer.
        Aug 31, 2017
        Paulmanlike likes this.
      3. HomeoHebbian
        HomeoHebbian
        Aug 31, 2017
        Melike, Fabrikat and Paulmanlike like this.
      4. Paulmanlike
        Paulmanlike
        Thank you for the link, I've seen that before. The presentation from Josef Rauschecker was on YouTube, if you type his name and tinnitus it should pop up first. There is a link to his slides on here somewhere I will try and find them.
        Aug 31, 2017
    4. Jim51042
      Jim51042
      Hi Professor. I'm a new member and had a question on your research. Is this a private way to message?
    5. HomeoHebbian
      HomeoHebbian
      Neuroscience Professor obsessed with understanding and eradicating tinnitus
      1. HomeoHebbian
        HomeoHebbian
        Sure, you can message me directly through the "Conversations" tab on this website. It is private.
        Apr 5, 2017
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  • About

    Gender:
    Male
    Location:
    United States
    Tinnitus Since:
    2012
    Cause of Tinnitus:
    Noise exposure
If you have ringing ears then you've come to the right place. We are a friendly tinnitus support board, dedicated to helping you discuss and understand what tinnitus treatments may work for you.