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Frequency are not using notch therapy - they are doing Progenitor Cell Activation. Completely different things.

We also have anecdotes from people on this site that the old Retigabine (Trobalt) helped their noxacusis.

Exactly - I think Retigabine could definitely provide symptomatic relief but at the end of the day it's not a curative drug or repairing the...

Right but earplugs aren't really "sound deprivation." Most musician's plugs and even most foam plugs are only reducing and taking the edge off -...

This is not the case and has been known for a decade - Robert Jackler from the Stanford Initiative to cure hearing loss mentioned that regrown...

It's always good to hear recovery stories but head's up everyone - DXM is not classed as a psychedelic drug, it is in fact a dissociative (e.g.,...

Yikes.

I mean, I don't think it's just some lone tiny minority of people on this thread who believe in this theory, as you seem to think. This is hardly...

Most of the discussion has been on Xenon Pharmaceuticals, which has developed a reformulated version of Retigabine with improved potency, safety,...

I think it's worth noting that last year the Hearing Health Foundation, one of the most prominent organisations in this space, published a post...

No, my first experience of hyperacusis was late 2016 which went away after a few months. I then had a major setback/relapse at the end of 2019 and...

It was related to my acoustic trauma and has lessened over time as my hyperacusis has improved. I don't have it any more.

There are closed captions.

Got my 1st Moderna vaccine this morning - only side effect thus far has been a sore and stiff arm. No effect on tinnitus or hyperacusis.

You did mean this as a joke, right?

Interesting discussion - for what it's worth, I have been on Concerta (methylphenidate) for 3 years but it has had no effect on my tinnitus...

The synapses that are involved in synaptopathy are the Type 1s which connect onto the inner hair cells. Nothing to do with the outer hair cells....

Every single time...

Rinri Therapeutics in the UK is using a stem-cell based approach... but they are in pre-clinical development. As an aside, Frequency Therapeutics,...

The webcasts are always available to listen to after the event if you go to their website.

I have wondered this too although it's important to point out that there are a lot of unanswered questions - see this talk Megan Wood gave from...

https://www.pipelinetherapeutics.com/news/Society-for-Neuroscience-49th-Annual-Meeting-Chicago.pdf It says right here that PIPE-505 leads to...

Just to clarify, PIPE-505 would regenerate the Type 1 synapses which connect to the inner hair cells. The OHCs synapse onto Type 2s, which are not...

Ah, I should have clarified this in my post but I do not have personal experience of the benefits system and am very fortunate to be living with...

I totally agree with you - I definitely think society fetishizes productivity and your self-worth is tied to your achievements. I think it's not...

Really good points and I just want to add that we should all be wary of "inspiration porn" and survivorship bias. Yeah, there are some people in...

To be fair, I feel it was balanced out by a fair number of people calling in saying they want regenerative treatments.

Incidentally, I have to say I was struck by how many participants reported persistent fatigue as a result of their hearing loss - to the point...

Omg when the presenter said they had a comment from someone who said "I have tried psychological help and sound therapy although these treatments...

Did anyone else watch this and catch the guy on the panel who has tinnitus and hyperacusis from a gunshot when he was 18? He had normal hearing...

David Lucchino will be presenting at 2 upcoming investor conferences - the Jefferies Conference on 2 June and the Goldman Sachs Conference on 10...

The event will be starting in an hour! There will be live captions available too. [MEDIA]

Certain antibiotics are documented as ototoxic - particularly the aminoglycoside class (typically ending in 'mycin') which tend to be the worst...

FX-322 is focused mostly on hair cell regeneration - it only regenerates synapses if the corresponding hair cell is damaged. However, given that...

Just to add, The Inner Ear Disorders Therapeutics Summit, will be featuring presentations from all the major players - including David Lucchino...

Thanks - I had an interview at the office last year (pre-COVID-19 lol) and it's not some open-plan office or anything and is a pretty small firm...

I don't think so unless you're working in a call centre or something? Maybe it's a cultural thing - I don't think it's that common in the UK. The...

It's not as bad as it was but I still get facial pain (like low-level throbbing/sunburn) from stuff like phone calls etc. I actually have just...

Please report back on how you get on! Will be interesting to hear.

New paper out co-authored by Liberman investigating the histopathology of both AHRL and NIHL. Is anybody here able to access the full paper?...

Age-related hearing loss is thought to be due in part to degeneration of the stria vascularis.

Professor David Baguley who focuses on tinnitus and hyperacusis certainly believes there's reason to be optimistic about hearing therapies in the...

Well, Liberman has shown that the synapses are the most vulnerable to acoustic trauma, moreso than hair cells. I suspect many of us with a...

This is a really great initiative backed by Tinnitus Talk as well as all of the big guns - Frequency Therapeutics, Otonomy, Decibel Therapeutics...

Otonomy is not the only company working on synapse regeneration - Pipeline Therapeutics also has a drug in clinical trials targeting this....

Fascinating work being done by Michael Levin and his lab on bioelectricity and its potential for regenerative medicine. The New Yorker:...

I started out with 15 mg but have mostly been on 30 mg for the past 3 years.

I don't think Mirtazapine is generally considered ototoxic - if it helps, I have been on it for 4+ years with no effect whatsoever on my tinnitus...

Oops I totally misread that! Glad that you have been referred to a specialist and I hope you get some answers and some relief for your lung...

There is increasing evidence that many cases of interstitial cystitis may actually be a chronic/embedded urinary tract infection (UTI). The...

This is so accurate. Even though I am mostly out of pain and grateful for it, I am still susceptible to flare-ups which can trigger my symptoms....

Type 2 synapses are different from Type 1 synapses - they are not destroyed or damaged by noise - in fact they have been shown to remain intact in...

Rinri Therapeutics has raised £10 million to support the development of their stem-cell therapy to restore hearing. Rinri Therapeutics Raises £10...

Yeah I imagine this is why mental fatigue and exhaustion are so commonly cited with hearing loss as your brain is having to work exceptionally...

We all want this to come out ASAP but to be honest I think it's wishful thinking at this point to think they'll be able to skip a Phase 2 repeat.