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Yes. The placebo effect can be so strong that people who got placebo surgeries think they were cured. It's why it's so dangerous; people don't...

Same, I reached out to him in June and haven't heard back.

Did your tinnitus go down to your baseline after stopping, or has it permanently increased?

Most welcome! I hope you find it enlightening. I'm sorry to hear that. I have often times found it difficult to process that I have caused and...

But that's what I mean. It's also literally what the authors say; I'm using their words. I don't think they're using "threshold" in the sense that...

It's possible. Although it's also possible that the pain has become centralized and treating the ear may no longer be effective. Who knows! I just...

I take it you have probably read this paper? An Integrative Model Accounting for the Symptom Cluster Triggered After an Acoustic Shock I'm...

Beat you to it! I'm doing that right now lmao. Thanks for pointing me towards it though!

I'm sorry to hear that. Thank you for trying it and letting us know how it went. Thanks for bringing PRP to my attention, I didn't know about it...

No drugs that are close to XEN1101's formula.

How did it work out for you?

As for Thanos' progress, he is right. Well, sort of. He's right that Thanos is still in the discovery phase with the drug. It's also true that,...

Thanks, man! Let me know what he says, if you contact him, and I'll let you know what they say if I contact them. Hopefully we can both find...

A couple of possibilities: 1) Retigabine binded to both Kv7.2 and 7.3 channels instead of only one of them. 2) (and this is the one I find most...

What's confusing is that there are lots of folks here for whom Amitriptyline worsened their tinnitus. Clomipramine is also thought to cause...

You are correct, but you've linked the wrong study. The one you've linked was a pre-clinical study done in mice. This is the study that reports...

From what I can tell, this is still unclear. People have tried to ask Thanos himself about this, to no avail. Some folks here seem convinced that...

What makes you say that, and where could I learn more about it? Someone correct me if I'm wrong, but I believe the most up-to-date information...

That is a very real possibility that we all have to keep in mind when thinking about the potential benefits about regenerative drugs. On the other...

Interesting! Thanks for sharing, I'm gonna send them an email asking about recent developments to the surgery too. I'm also curious if leaving the...

I am once again considering this surgery, now more seriously than ever. My impressions are the same ones already discussed here: many people seem...

Can't disprove you. Can't prove it either. Ahhh, the woes of having no evidence...

I just checked that. Tinnitus isn't explicitly in their exclusion criteria, although they do exclude participants with "any unstable medical...

No. The last update from Dr. Shore is still the email she sent in April. From that, we know that their next steps are to 1) publish the data from...

I find that unlikely, as FX-345 hasn't even started phase 1 yet. But then again, this thread was started 10 years ago, so...

OTO-413 reported positive results not too long ago.

This is something that gives me hope, to be honest. Even better is that all these companies are, as far as I know, working on different approaches...

I can certainly agree with this, and I see this happening with a lot of other treatments here (most notably, recently, with Dr. Thanos...

Thanks for sharing! For anyone else following this thread, just note that this study has already been posted here before. Not a dig against you, I...

Honest question, though: how is a lack of benefit against placebo across most of these trials anything less than a worrying sign? I understand the...

I think the point being made is that it's getting harder for them to argue that the reason for FX-322 underperforming is trial design (rather than...

Always nice to hear positive results! Thank you @Nobody19 and @patorjk for staying on top of all these developments and sharing them with us. I am...

Why would reorganization be impossible? Just the simple fact that hearing aids suppresses tinnitus for some people shows that the brain does have...

I don't think there's much to read into here. This was a small research conference, it's pretty typical for those to not be recorded.

Just heard back; unfortunately, they didn't record any sessions at the conference.

Just sent an email to a conference staff member asking if Shore's talk was recorded (and if the recordings will be made available to the general...

I'll concede that saying positive results on clinical trials are "the only thing that matters" was a little unfortunate. It leaves too much room...

I'd argue that the only thing that's going to matter is actually positive results on their (double-blind, sham-controlled) recent trial. Patient...

It's in clinical trials, not available yet. Many people tried an earlier version of this drug, with varying results. Keep in mind the new version...

Yes. TDLR: they are interested in the drug's potential for treating tinnitus but, so far, there are no concrete plans for clinical trials.

The results are ambiguous though, so I don't blame you. According to them, before treatment, persistent tinnitus was found in 100 ears, and after...

Would you mind linking the study? I'm having a hard time finding it, and am curious as to how they measured the reduction of tinnitus loudness.

Great find! Thanks for sharing. It seems like a lot of electrical/magnetic ear stimulation treatments are popping up: Dr. Hamid Djalilian is...

This is a pre-clinical study, it's meant to serve only as a proof of concept. Placebo/control group testing is more of a Phase 2/3 thing....

Yeah, reading over the inclusion/exclusion criteria again, I think you're right. Maybe this is another layer of protection against people lying...

Mammals lack the ability to regenerate synapses in the inner ear. It's just something we can't do. However, some studies have shown that applying...

Sorry, I forgot to quote that part of your last post, but I meant to say I absolutely agree with you on that! At the end of the day we all want...

He did say this: If you mean that he never said if his tinnitus went away eventually, years after the treatment, then yeah, you're right, he...

Why not? If synaptopathy leads to fewer/aberrant signals being sent to the brain, this could result in tinnitus. One could make the same argument...

I thought I'd do a brief recap on the state of deep brain stimulation trials as of June 2022: There are two trials going on in Europe, one from...

I know you're speaking hypothetically, but do you (or anyone else) know if there are any progress in bringing DBS to market? Any clinical trials,...

This is likely a direct nod to the FX-322 trials, and has been discussed at length in the OTO-6XX thread (@patorjk did a great job of hunting for...

Great find! They seem to have three drugs in their pipeline, all in the preclinical phase: TT001, previously called AZD5438 TT002, previously...

Even that is pretty amazing considering how heterogeneous hearing loss is. IIRC Otonomy didn't set any specific criteria for how participants got...

I think you read it right; IIRC it lasted longer for some people, but nevertheless you are right that it doesn't last indefinitely. The hope is...

According to Thanos Tzounopoulos, Kv 7.2 and Kv 7.3 are the most important ones. More sources: Transient Delivery of a KCNQ2/3-Specific Channel...

There seems to be two big theories nowadays: an inner ear theory and a middle ear theory. The inner ear theory says that type II afferents in the...

I didn't interpret it like that. I think the 20-30 year timeframe is Djalilian's way of expressing just how monumental of a task hearing...

Thank you Brian, for your contribution! I know Dr. Djalilian's device is likely many years away from commercialization, and that we need proper...

For anyone who's missed it, here's the podcast episode that features this discussion. I gave the episode a pass at first as I find accounts of...