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Subsonic ammo and a suppressor will be staple gun quiet. Add hearing protection on top of that and it will be very quiet. Now shooting around...

You probably have the standard 4 kHz notch that many people get. The ringing is hyperactive nerves making up for the loss off signal. Usually the...

I just ignore it less. I think some of it is real (the tone is really there) and some might be my hearing.

She won't. My bet is the University will likely look for someone to license the tech to that will commercialize it. Notice on the last page...

A hair cell is a hair cell and there is no fundamental frequency response difference between cells. However, the location within the cochlea...

I'm speaking on as to how their respective drugs worked in the lab. Frequency Therapeutics is trying to expand the number of LGR+ progenitor...

You are assuming both will provide equal results. The literature suggests FX3-22 “cocktail” of small molecules will produce better results than...

Yes, but premature loss of those frequencies (8-16 kHz) would be an indicator of hearing loss and could warn people to start making lifestyle...

Yes, there is a delay of about approximately 10s to 100s of milliseconds before it comes back.

Your average Dr. practicing medicine in a clinic or hospital is just a product of the medical education system. They are taught the literature on...

This is pretty cool. Hopefully the only side effect is increased happiness!

In the United States it is now the first to file for a patent that gets patent protection. It used to be first to invent, but that changed...

The difference in pace is clearly pure market capitalism vs a government grant. Where did you see 2020?

Thank you for posting this. I know first hand that T frequency and hearing loss are perfectly correlated. Wherever I have a notch, there is T...

Elon Musk knew nothing about rockets 20 years ago, but here we are today with the most cost effective solution to putting things into space with...

I have multiple frequencies of T. I have a 13kHz hiss and a 1.56kHz ring in the right ear. Both of these are modulated by different parts of my...

Can you ask them if they are considering this? :-)

@kelpiemsp can you ask them if they plan on treating multiple tones? Suppose different tones in each ear or multiple tones in the same ear.

This trial is simply a risk reduction trial from a business standpoint. Call it whatever you want for the FDA, but there are unofficial trial...

Did they state why it needs to be above 3 kHz?

6db is double the amplitude, not necessarily the volume... http://www.sengpielaudio.com/calculator-loudness.htm

This site has tones you can play at 10db intervals https://www.audiocheck.net/testtones_hearingtestaudiogram.php

Doesn't sound like much when you listen to it at full volume, but when you play it at a low volume you can definitely see how 10db could push a...

White noise would be noise across all frequencies.

Be careful by just saying it takes xx db of sound pressure to mask your T. It really depends on the spectral content of the noise. If you have...

Great news. So 7-10db would imply that it’s about half as loud as pretreatment. Is that about what you estimate?

If support cells are there I think it will help. Frequency response is dependent on location in the cochlea. Basically it is sort of like a...

Yes once it gets bad enough.

It is a bit concerning I see no listing on the clinicaltrials.gov website for this Alamo trial. It just shows that the Phase I was completed. It...

I find it interesting they say that it is located at the "Phase I Unit". Not sure if this is just the name of the building that gets used for a...

I believe many cases of tinnitus "without hearing loss" is actually tinnnitus with hearing loss. You can actually get very narrow notches in your...

Where did you hear out hair cells are only 5% of the population. Everything I've seen suggests 3 outer hair cells to 1 inner hair cell. Look at...

Frequency is likely using it in their FX-322 based on their prior published papers. LY411575 is also the most potent Gamma-secretase inhibitor...

This is the company that is tied to Hough Ear Institute: http://otologicpharmaceutics.com/

10db is considered twice as loud. Some will argue between 6-10dB.

Where did you hear this? Source?

Definitely good. The rubber meets the road when they do human trials though. Sometimes things don't work on humans that worked in other animal...

He comes from Eli Lilly. I believe LY411575, the most potent (that I'm aware of), gamma-secretase inhibitor is made by Eli Lilly and is what...

I also think it would be worth gathering data for members here about tinnitus frequency among other things. Everyone here has tinnitus, but...

~10-13dB recovery through direct differentiation of support cells. Not too bad. That's a bit over a 2x improvement in hearing thresholds.

@Aaron123, were you going to buy a copy of it?

Hopefully guinea pigs means humans are next. Hough has been working on this for awhile. This is from 2012....

I wish there was a cartoon of this. So the LGR5+ support cell divides through wnt signaling, the resulting new cell converts to a hair cell?...

Aaron, have you seen anything in the literature about whether the Lgr5+ cells convert directly to hair cells after division or does another...

Tylenol(acetaminophen) is hard on your liver. You might want to keep that in mind as you evaluate you treatment options.

Don't Die. ;) I've heard similar to what face2black said.

I believe this a similar drug to what was used in this paper. https://www.nature.com/articles/srep24907

That's $3,000 per ear if I'm doing the math right...

ACRN was based on a poor understanding of the root cause at the time. Also the studies provided poor evidence that it even worked....

Disagree. The rarer the disease, the more expensive the drug. The market for hearing loss is huge. They could sell it for a sky high price, but...

This is great news! Hard to tell how the contraption works. Looks minimally invasive? However, is the treatment permanent or do you have to...

My audiogram is normal. However if I do a test in my closet using the tonegen app on my phone I find there is distortion at very low volumes at...

Try these for the movies. They cut everything down, but still allow you to have normal conversations vs. the foam plugs....

By the pictures it would appear both inner and outer cells.

Agree that it will be organized, but look at Figure 7c compared to treated 7d myo villa The inner cells, went front 1 to two in a row and outer...

It would be interesting to see what he thinks about overpopulation of hair cells. If you unroll the cochlea so its like a piano, the inner cells...

PM me if you need some help. I've read both your posts and I think you and I have quite a bit in common. Its still a battle for me every day....