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I felt pretty bad when I saw the news about the failed trail, but I was doing well at the time. I had a bad spike after a motorcycle journey...

I do wonder what the impact of the diet etc. of those in these studies is on individual outcomes. Many people carry around one or more...

But Elon is very good at commercialisation at scale. Also, the performance of all the rockets that exploded was rudimentary, until they didn't.

I'm going to inject what I can, snort what I can't, then chase with vodka.

*Hearing loss and tinnitus drugs in trial pipeline* I am not sure how much closer you can get, there being multiple drugs in the clinical trial...

So the incidence rate of 10% or more improvement rose with multiple doses? Although the rate of larger scale gains decreased? Or am I wrong?

In the middle of a terrible spike, for ten quid, I decided to give this a go... Some peaceful dreams would be nice :)

I am unsure that this is a given... Can't injection of a placebo have harmful effect, due to physical phenomena alone?

I am the opposite, I never have spikes, just changes in attitude when it gets too much to bear... I guess this means that I am in the pool of...

I have devoured so many of your posts that it feels like conversing with a celebrity! I am an engineer, not a scientist, but digested the 2009...

Sorry all, another refugee from the FX-322 thread here... Having worked that thread for over year and jumping ship to skim read the last few...

Checking in for the first time in months. The news didn't do me any good, but the ongoing analysis is super appreciated. Feeling informed feels...

Same way doctors actually know very little about HOW what they do works. I mean, you can learn this at med school, but no practicing local GP is...

They can impact your handling of ANY challenging stimulus.

This is the man who made the viable electric car company. Then made it self driving. Commercially viable without subsidies. Who then got NASA to...

So at a random sample this would be 1/4 for two to get placebo. But in my head people who it works for are more likely to stay quiet. They got...

Hi there - so is this thought to be bad news from a development perspective (independent of timelines)? Is there scope for them to modify a trial...

Thanks for staying on top of this guys and digesting the information by discussing it back and forth. It's super appreciated.

There is precedent of this happening.

Would this work, or just compress the gas in the inner parts of the inner ear, advancing the drug down the tube only incrementally?

The question is intriguing, but extreme and at a great disconnect to the reality of where we currently believe ourselves to be with this. I am...

Hope so! Trouble is I can't help but feel that the exposure decay will be exponential within the cochlea - a bit like dropping a blob of paint...

Phase 3 might not be required however.

I want to include a disclaimer with this one, and don't mean it for you necessarily, but others lurking. These 'online tests' are VERY biased to...

Also you may want to look into residual inhibition and reconsider your assumptions. I am not saying you are wrong, but residual inhibition, to me...

Wait what.

Again people, some drugs are released on phase 2 data. See my previous post :)

47 days!

I am, I'm building this as soon as my current project is done :)

https://www.forbes.com/sites/aroy/2012/05/04/should-the-fda-approve-more-drugs-after-phase-ii-a-response-to-matthew-herper/ See the above link...

Has anyone been accepted for Lenire treatment with non-constant tones? E.g. crickets?

My pet theory on all this is that the audio processing part of the brain has focused on a certain frequency set within the auditory brainstem. I...

@JohnAdams - Was it you that didn't have any joy with Ginkgo? I was wondering if I should try this with my curcumin. Am never sure what to...

I'd do it. In fact these reports have convinced me to get on the waiting list for one. Change, in my mind, is evidence of function. Got an ENT...

Not that kind of funny. I have kept tabs on these discussions and take 3g a day. No benefit for me yet, alas, but given the topic of this...

We can't know. The link above suggests this is a possibility...

I hope this is the case because they are intending to go fast track and get approval (possibly subject to periodical review) with phase 2 data....

Thanks for the above; I am hoping that we might get an update on approval strategy at some point... Especially since this site claims, amongst a...

I think I am am optimist, but I struggle to envisage them treating both ears in direct contradiction of the stated trial criteria and control? Not...

Sorry, I have scanned the above posts, where is this? I'm probably being blind lol, today had been bad.

I appreciate you are a pessimist due to your experiences. This is very valid position to take. But what has really struck me is that most of the...

I don't know if you suffer from hearing loss, but I do. My tinnitus is far worse in the quiet, because it is more obvious to perceive. The world...

That sounds crazy promising. I'll look for a paper later "Clonal Expansion of Lgr5-Positive Cells from Mammalian Cochlea and High-Purity...

I couldn't recall if we had seen reference to multidose treatment in rats for example, that would support the upcoming trial.

Thanks everyone!

I have a question in turn. Do we know of any lab results that support multi-dose performance? I know that it must exist... but I want to read it...

Source: Adams, C., & Brantner, V. V. (2003). New Drug Development: Estimating Entry from Human Clinical Trials. SSRN Electronic Journal. This is...

Anyone got a capture scope that they can stick on one of these things? I want to black box model it and build one.

I to be honest fail to spot the 'naked greed'. Look at it this way - if it is competing with HAs then the better it works the higher the price...

They will be looking at multi-dose trial. I guess the then preferred dosage scheme is dependant on results. No results in humans detailing...

This isn't an orphan drug though. The market is huge and to tap a real portion of that market they will need to compete with hearing aids...

My thought as well - I have 30 dB hearing loss so I should fall with a foot in the camp whichever way it wings for, high or low, rights XD. The...

I was wondering this as well? Let's say the benchmark is 100 million+ in funding injection and a partnership with a major pharma distributor on...

In before: "It worked, bye." XD

Just joined this thread from the dark of the research section. I am a skeptic about everything, but I hope to hell you guys find peace through...

As I remember it was 8 8. Haven't checked today am probably wrong... :P

Part of me agrees... but what do we expect them to say and how long do we think it will take them to say it? Assumign that everyone present is...

It would be nice to see some long term improvement monitoring in the next study (or this one!)

Sorry - I have read it in full now. So yes FX-322 is 'combinational'. If this is the only such example then my hopes are still impacted - a one...