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CBS ran the report. Not Frequency Therapeutics.
Sounds like the hyperacusis I had for a long time. But I think the better term is "recruitment." Basically what's happening is you've got some...
It may or may not need a Phase 3. Depends on if Phase 2b meets endpoints, and FDA says a Phase 3 is needed. By now, almost 300 patients have...
The FDA is specific on approving a drug to be sold in the US: 1. Favorable safety profile (low risk, or well-defined risks). 2. Specific target...
A quack.
This honestly seems about right in terms of sale price. Consider what an asset pricing sheet for the patents / know-how would look like. They have...
Yes. Over time the occasional gathering will be fine.
They received a grant from the DoD prior to the FX-322 Phase 1/2.
Today is my 4th anniversary of acquiring intrusive T and H. To those of you that are new and still struggling to cope... it gets easier.
It depends, but until a few million people have sampled the drug in their ears, one can only speculate. I suspect genetic conditions play a factor...
It should be noted that the drug cannot provide a permanent gain, either. It has demonstrated that to some extent it is causing the regeneration...
He wouldn't have been allowed into the trial (assuming Phase 1/2 based on the description in the video) unless he had demonstrated that his...
I wonder if he was patient 937 from the Phase 1/2?
If the OTO-413 trial demonstrated more convincing positive outcomes, they would certainly not have gone down the same path. They would have...
It's unknown. So just saying "multiple doses didn't work" is misleading. And FREQ hasn't bothered investigating timing of the dosing, or any other...
Sorry, but you won't win. In almost all countries, the purchasing of a ticket itself is a contract between you, the promoter, and the venue where...
Not likely. Their research is positioned to activate progenitor cells throughout the body. After focusing on the ear with FX-322 / FX-345, they're...
The Phase 2a with 0.3 mg had favorable outcomes. It was the high dose cohort evaluation (0.75 mg + 1.5 mg) that did not show improvement. This is...
If the Phase 2B produces positive results, they’ll most likely stick with the trial design in Phase 3. They’re more focused on word score deficit,...
Wonder if the higher doses overdid it like the multi-dose FX-322. Anyways.
Looks like they over-recruited. Hoping that's a good sign for data outputs.
You're right. It is... so could be any time.
Start of Q4, 2022.
Secondary outcomes of the current FX-322 Phase 2B should inform the decision on the question of "Do patients actually get helped." or "Does their...
Learning how to properly insert a foam earplug goes a long way. Back when I did go to the range, I'd say 50%+ of the people wearing earplugs...
We have to remember that these companies first and foremost live and die by the success of their trials. So designing a good trial is really...
The implication has been that inner hair cells are regenerating, but possibly not (or not enough) outer hair cells. This would explain the word...
It does happen. Firms sell IP to larger entities (corporations, universities, governments) that have the resources to re-trial / re-formulate /...
Fed rate hikes have little to do with their cash on hand. Inflation will cause them to burn more quickly in the short term. And frankly, there is...
Frequency Therapeutics released evidence of suppressed word recognition scores used by patients to gain acceptance into the FX-322 Phase 2A. Which...
Not to be an ahole about it... but OTO-313 was never for the chronic cases that most of us have been living with for years and years. It was a...
I'm going to quote one passage from the recent press release: "These results were unexpected with a much higher placebo response than observed in...
It's way higher than 3400 Hz. Take a look at the speech banana: Fricative sounds: F, TH, S, are highly used in English are produced north of 4000...
Now that the trial is over and dead, and although I was one of the members here protesting you talking about your experience during trial, it...
This would be a good time for Astellas to buy them. Astellas seems eager to get into the hearing space. Even if OTO-413 Phase 2+ looks good, it's...
Weber's comments re: Placebo sound eerily similar to the FX-322 Phase 2A comments from Lucchino.
It's called a "Future State."
Patient: Complaint of tinnitus following loud noise exposure. Doctor: Administers OTO-313 to get tinnitus under control and reduce long-term...
It depends by the term "better." Based on this site, and on those who joined due to a noise injury, in the short-term (let's call that a year), it...
Classic observations of the brain by researchers of tinnitus patients have led to this conclusion. It's the "best" explanation provided thus far,...
It sure is, but it does improve with time. It's like your ears start to get more "tolerant" of some noise exposure, but it never goes back to the...
Whenever you feel it’s too loud. I spiked easily at first, over time, you can go to moderately noisy restaurants at lunch. Bars, maybe not. But...
Earplugs. That's it... I travel for work, I travel for vacation. Earplugs.
It's not well understood. You can't quite point to the exclusion criteria in the trial to know for sure; that criteria is to ensure the trial...
That's what's interesting about FX-322 / Progenitor Cell Activation. In vitro, Frequency has observed the output of PCA where a new daughter cell...
This comment describes what should be known as the “Tinnitus Talk Paradox”... 1. A claim where ENTs have academic training, years of experience,...
I don't see it as something that is "worrying"... I see it as scientific discovery happening in real-time, and in front of the public. This is...
201-1 = (Phase 1/2) SSNHL and NIHL Study Mild-Moderately Severe [18-65 y/o] 201-2 = Phase 1/2 Durability (Long term study) 111 = Study of...
They did test with the extended high frequency in the Phase 1Bs and 2A. However, didn't see anything meaningful. The Phase 2A data was trashed by...
The difference is that bird/reptilian/amphibian progenitors can still be signaled by the body to "turn on" and complete mitosis. Mammals lack the...
No. I think either FX-345 OR FX-322 could be complimentary to OTO-413. The drugs address exclusive underlying conditions of Acquired SNHL.
FX-322, FX-345, or OTO-413 could help you individually or in combination. It's too early for anyone on this forum to give you a definite answer.
The majority of hearing loss patients have acquired (Noise, SNHL) losses that are between mild and moderate. Severe or profound makes up the...
No, probably not. No, probably not.
I suspect it was because the entire 15k hair cells weren't restored. So, the new ones are there, but existing hair cells deeper in the cochlea...
I still don't get how OTO-6XX is intended to cause damaged cells to repair themselves. FX-322 activating progenitors isn't exactly new science,...
Sounds to me that OTO-6XX is a long, long ways away.
Application takes time with FDA, setting up trial sites takes time, staff limitations to manage more than 1 trial.
Wow. A T "OG" ... tell us about how its changed over the years.
Let's keep in mind that not being tested in the Clinical Trial doesn't mean that the company doesn't think it will help. The exclusion/inclusion...