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You forgot the story of people turning blue (irony). Trobalt was not the poison some people would have you believe. Definitely a drug with too...
I think that instead of making assumptions (positive or negative), it would be more helpful if everyone consulted Dr. Shore's patent.
In Dr. Shore's paper, timing is parameter #1. Lenire is based on a different theory I know, but where Dr. Shore's papers are well constructed,...
Lenire uses a Bluetooth system, which is a disaster for a system where the timing must be precise to a millisecond range. This unnecessarily...
not really reactive (only on very specific conditions, so it happen like 3-4 times per years), so i can't say
Of course it's your choice, but Lidocaine alone does not have much benefit beyond what we know. Personally, I have never had any problems with...
Is there evidence that the GABA activity of Retigabine is a different mechanism from other drugs that act on this neurotransmitter?
I responded to you but my message was altered or deleted. To put it simply, yes, I got an objective reduction with Retigabine, because I simply...
Yes, I use it in "Aspirin mode" for now, but I plan soon to start a 3 x 400 mg/day treatment for 2 months.
Our greatest fear is that the selectivity of XEN1101 doesn't activate a channel necessary for tinnitus suppression. I'm of course thinking of...
If I recall correctly, in the patent.
No, the stimulation is not more important than the sound. In fact, according to the papers, the stimulation part alone tends to temporarily worsen...
So I imagine you were receiving a shallow injection into the skin of the ear canal? Do you remember how long your ear was anesthetized after the...
I guess it will take another year after the FDA decision to think about what to do, and waiting another year to start thinking about production...
It would not be a surprise for me if a relatively effective path remained forgotten. I remember the total immobility of tinnitus sufferers during...
Apart from the tolerance which can develop over time, like a lot of drugs, the random effects of Retigabine must be able to be explained in my...
This effect on smooth muscles may be the cause of certain side effects of Retigabine. Particularly on urinary retention and cardiac “disorders”....
Interesting. This may be one of the explanations for why Retigabine doesn't work for everyone. But according to the anecdotes we have, it's...
These heavy side effects were also associated with Gabapentin and my emotional state so it's hard to be sure. I prefer to warn when in the doubt....
Yes, this has always been the case so far, from almost nothing to heavy side effects. Most of the time it is a state comparable to alcohol...
The chemical reality of the drug is more important than a few numbers on the box It's viable
Thanks for your useless opinion ajc. It confort me in my choice to not listen people who speak without knowing anything
Nope, it's "fresh" retigabine since it was well stored (in freezer)
Both. In January I took it x3/day for 2 weeks; it worked only 2 times. I adopted an Aspirin approach, x2-3 per week in the month of May; 100%...
300 mg and 400 mg. It's very random, sometimes 300 mg works better than 400 mg etc, but under 300 mg there are no effects at all. Side effects...
Indeed. I got tinnitus in August 2020. I started first Retigabine experiment in January 2023 but without real success. My first success is in...
No, but I think I didn't took the treatment long enough for that It's my actual goal
I got my tinnitus 3 years ago, so it seems to work for chronic cases.
I think it's related to CI in my case, bc this T can reach other side, at least not in brain. Idk at all, RTG is so random, i took time to make...
It helped my somatic tinnitus, yes, it 90% vanished for 1 hour. It probably did something for the non-somatic tinnitus, but far less than for my...
My somatic T generally responds well to RTG, can reach 90% at hight dose. My non-somatic T reacts only slightly (20% placebo range), but I think...
May I ask what was your dosage?
I asked to Dr. Shore 4 months ago if my case (noise trauma, 50% somatic and 50% non-somatic tinnitus) could benefit from this technology. She said...
From my experience, Retigabine tablets are not divisible in themselves, but with a scalpel and a small precision scale you can do it with an...
And some money consideration, to be honest. Again, Retigabine indeed has heavy side effects but these mainly concerned high doses in the...
@StoneInFocus, you can criticize my intelligence and my English if you want, but apart from proving that you have nothing left to say except...
There's nothing to respond to someone who only contradicts for fun. I agree for the rest.
Of course, there is no evidence that XEN1101 is a superior remake of Retigabine, that's our hope, it's consistent, but it's not proven. I remind...
It's especially the desire to converse with you that I miss, you only question dominant theories by raising non-questions, with a quite clumsy...
Dude, I'm not changing the subject at all. I don't know what you're trying to say, it's pretty well documented here that Kv7.2 and Kv7.3 are...
Precisely because Retigabine is a Kv7 opener and Gabapentin is not, at least much less so.
Well, in most of the papers I've read about Kv7s and tinnitus, there's rarely any mention of channels other than Kv7.2 and Kv7.3. If you have...
Let's say I did more than just theorize. Besides the hundreds of papers on the auditory system, experiments (including Trobalt for example, but...
That's exactly the point. I don't have an answer, I just know that according to the dominant theory Kv7.2 and Kv7.3 are "enough". K7.4 is indeed...
In my case, Gabapentin is incredibly weaker in terms of efficacy on tinnitus than Retigabine (Trobalt), although I think they make a good combo....
No I don't have any hyperacusis/noxacusis, I can't do any statement about that.
Well, I don't know if it fits in the charter, but Trobalt by far. I was lucky enough to get some stock from someone who kept it in a freezer....
Kv7 openers. It's far from a miracle but it's the only thing in 3 years of tinnitus that has objectively destroyed my tinnitus temporarily.
Well, is it temporarily? Does this concern all tinnitus or just one tone? What is the dosage/effectiveness ratio? That kind of stuff, but don't...
It's a very vague answer. Anyway, happy for you.
I used Gabapentin with a Kv7 opener. From what I understand in my case (related to hearing loss), tinnitus is largely a central problem, maybe...
You scale at microdoses guys, I find it hard to see how such a low dose can have any effect, I hope it's not a placebo. Here the ENTs prescribe...
Can you tell me where you see that people with non-somatic tinnitus can also get a benefit, please?
First, you didn't understand what I meant, I'm simply saying that there is a huge interest in knowing how far her device can act in the auditory...
There is currently no evidence of the extent to which this treatment is effective, and I speak from experience. It seems obvious that it works for...
For a so-called scientist, I noticed that you are very approximate in your interventions. Like when you claimed FX-345 was the same formulation as...
Can you tell me where you got this information please? And indeed, this corresponds to the electrical impulse.
Do you want to wait for the results of the guys who are doing the HEI project or do it before?
Don't be put off by proponents of the old "stuck in the brain" theories and other variations like DDR. Their arguments aren't all wrong, but if...
This is the problem: This single dose study didn't have a placebo control. But the results were no better than the placebos in Phase 2a. I...
