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Don’t forget FX-322. That will probably come out first before Ebselen.

Hopefully if Phase 2 results look good, they can skip Phase 3 but I don’t think that will be happening. I guess it will be 2023 then.

How come the Phase 2 trial for COVID-19 ends in 2022? I thought with the urgency they could do all Phases within a year for COVID-19?

Thanks for the clarification. I thought it was coming out either the end of this year or early next year but I guess that’s not happening.

Damn, I thought they were going to start Phase 3 but the ClinicalTrials.gov website states Phase 2.

I would like to know if it was a temporary or permanent solution after their 28 day supply of Ebselen runs out.

When results come out in April 2021, how soon can Ebselen be released?

If Ebselen turns out to get rid of pain hyperacusis then thank God because this will be the first drug to help us. I still think FX-322 will be the one to help us with pain hyperacusis but if it turns out it will be Ebselen then I hope we don’t have to take it long term.

I know it sucks that we are suffering from this. I just really hope SPI-1005 helps with pain hyperacusis but if not we have FX-322. Please help us.

Not sure. I have no clue how long we would have to take the drug.

Yes. Right now it’s in clinical trials for COVID-19. The results should be out in April and, if positive, could be released in late 2021-2022.

Pain hyperacusis sufferers are like trying to connect the pieces to a jigsaw puzzle. We still don’t know why we are getting pain hyperacusis whether it is inflammation, IHCs, OHCs or synapses but we will find out soon enough with SPI-1005, then FX-322, then OTO-413. We are nearly there to a...

Of course it won’t be simple. It was just a theory on what might happen when taking the drug.

Not sure how the drug works. Maybe you take it for a month until the inflammation goes away and then pain hyperacusis goes away.

Is Ebselen what is in SPI-1005?

Let me know how it goes. Does anyone have links to both the Meniere’s and COVID-19 clinical trials for SPI-1005?

Fuck I’m glad it’s in tablet form. If it comes out in the United States will anyone be trying it for pain hyperacusis first or are you going to wait for an anecdote?

Is SPI-1005 an injection or a tablet that you consume? When are they likely going to release SPI-1005?

I really do hope that restoring the OHCs will self-correct itself and stop pain hyperacusis.

I still believe that to stop pain hyperacusis you need to fix the fundamental issues in the ear such as OHCs, IHCs and synapses. I don’t think it is inflammation that’s causing the problem but it would be good to find out anyways.