Cinnarizine/Stugeron

Discussion in 'Treatments' started by tweak, Apr 24, 2012.

tinnitus forum
    1. tweak

      tweak Member

      Tinnitus Since:
      03/12
      Hi,
      Has anyone tried this? Someone who had pretty bad tinnitus told me this helped them. There does not seem to be much evidence whether it helps or not. So anyone have experience using it?
      Thanks
       
    2. calin
      Inspired

      calin Member Benefactor

      Tinnitus Since:
      Oct 2011
      I give up Tweak! What is it? haha ... obviously I haven't tried it as I don't know what it is.
       
    3. tweak

      tweak Member

      Tinnitus Since:
      03/12
    4. calin
      Inspired

      calin Member Benefactor

      Tinnitus Since:
      Oct 2011
      Cinnarizine (Stugeron, Stunarone) is an antihistamine which is mainly used for the control of nausea and vomiting due to motion sickness. Cinnarizine was first synthesized by Janssen Pharmaceutica in 1955. It is not available in the United States or Canada.
      It acts by interfering with the signal transmission between vestibular apparatus of the inner ear and the vomiting centre of the hypothalamus. The disparity of signal processing between inner ear motion receptors and the visual senses is abolished, so that the confusion of brain whether the individual is moving or standing is reduced. Vomiting in motion sickness is actually a physiological compensatory mechanism of the brain to keep the individual from moving so that it can adjust to the signal perception.[citation needed]
      Cinnarizine could be also viewed as a nootropic drug because of its vasorelaxating abilities (due to calcium channel blockage), which happen mostly in brain. It is also effectively combined with other nootropics, primarily Piracetam; in such combination each drug potentiate the other in boosting brain oxygen supply.[citation needed]
      While this may be true, cinnarizine is also known to cause acute and chronic parkinsonism[citation needed]probably due to its affinity for D2 receptors, which strongly countersuggests its actual usefulness for improving neurohealth.
      Cinnarizine can be used in scuba divers without an increased risk of central nervous system oxygen toxicity.[1]
      Cinnarizine can cause drowsiness and blurred vision. It is important that users make sure their reactions are normal before driving, operating machinery, or doing any other jobs which could be dangerous if they are not fully alert or able to see well.[citation needed]

      http://home.intekom.com/pharm/janssen/stugeron.html

      PHARMACOLOGICAL ACTION:
      Cinnarizine inhibits contractions of vascular smooth muscle cells by blocking calcium channels. Cinnarizine increases erythrocyte deformability and decreases blood viscosity in vitro. Cinnarizine inhibits stimulation of the vestibular system.
      PharmacokineticsThe peak plasma levels of cinnarizine are obtained 1 to 3 hours after intake. Cinnarizine disappears from plasma with a half-life of 4 hours.
      Cinnarizine is completely metabolised. About 1/3 of these metabolites are eliminated in the urine and 2/3 in the faeces.
      The plasma protein binding of cinnarizine is 91%.

      INDICATIONS:
      Control of vestibular symptoms of both peripheral and central origin and of labyrinthine disorders including vertigo, dizziness, tinnitus, nystagmus, nausea and vomiting.
      Prophylaxis of motion sickness.
      Adjunct therapy for symptoms of peripheral arterial disease.

      Ok! So, who is going to try it out?????????????? Any guinea pigs???

      GOOD FIND TWEAK! It just may help someone out here!

      Nerves situated inside your ear send messages to your brain with information about your movement. Along with messages from your eyes and muscles, these nerves help your body to maintain a good sense of balance. If the nerves in one of your ears send too many, too few, or wrong messages to your brain, it conflicts with the messages sent from your other ear, your eyes, or your body. Your brain then gets confused and this can cause dizziness, vertigo (a spinning sensation), tinnitus (a buzzing or ringing in your ears), and can make you feel sick. Cinnarizine helps reduce the feelings of sickness, vertigo and tinnitus caused by problems such as this.

      Cinnarizine is also helpful in preventing travel sickness. Travel sickness is caused by repeated unusual movements during travelling. These repeated movements, such as going over bumps or round in a circle, send lots of messages to your brain. The balance mechanism in your ear sends different signals to those from your eyes, which results in your brain receiving mixed and confusing messages. This is what causes you to feel sick.

      Cinnarizine is available on prescription, or you can buy it at pharmacies, without a prescription. It can be taken by adults and by children over the age of 5 years. http://www.patient.co.uk/medicine/Cinnarizine.htm

      http://www.tinnitusjournal.com/detalhe_artigo.asp?id=261

      The Efficacy of Arlevert Therapy for Vertigo and Tinnitus

      CONCLUSIONS
      From this study, we conclude that Arlevert has good antivertiginous and antiemetic properties. It proved to be effective therapy for patients with vertigo or tinnitus of peripheral vestibular or central origin. Our statistical evaluations show Arlevert to be more effective than either of its constituent drugs (dimenhydrinate and cinnarizine) used separately. Finally, Arlevert was well tolerated by the patients in our study.

      DISCUSSION
      In this study are presented the results of subjective observations of our patients and objective tests including CCG, ENG, and audiologic assessments. From these statistical evaluations, we are able to summarize that Arlevert produced the best results, followed by dimenhydrinate and then cinnarizine. On the basis of our findings, we suggest that in Arlevert, the various properties of dimenhydrinate (e.g., peripheral depressant action at the labyrinth, especially to the otoliths [1], and very strong anti vertiginous and antiemetic influences [2]) and of cinnarizine (e.g., sedative action on the vestibular labyrinth, as a calcium entry blocker, and antivasoconstrictor properties) have been successfully employed [3-5]. Thus, we have observed very good results in treatment of vertigo and tinnitus, not only that of peripheral origin but also that of central origin [6-9]. The small effects in threshold audiometric and ENG results can be explained by the fact that the majority of our patients had suffered hearing loss for 3-5 or more years and so could not be expected to exhibit very marked changes in these tests. Among the "fresh" cases, patients (only a few in this group, and most young) usually recovered considerably-to the physiological level in both audiometric threshold and ENG tests.

      This looks promising for some. They even mentioned hearing loss improvements on that last link I gave.

      Karen - are you seeing this?
       
    5. Karen
      Talkative

      Karen Manager Staff Benefactor Hall of Fame Ambassador

      Location:
      U.S.
      Tinnitus Since:
      05/2010
      Cause of Tinnitus:
      First time: Noise 2nd Time: Ototoxic drug
      Yes, thanks! It does look promising. I'll need to do a little research on this; I want to know how it might interact with other drugs/supplements. Worth considering. I'm kind of "chicken" (read that wary and cautious of an interaction), so I don't know if I'll be the first to try this. If anyone out there does try it, please let us know!
       
    6. Maria

      Maria Member

      Tinnitus Since:
      december 2012
      Hi Tweak,

      I have been suffering from Tinnitus since November last year. I wen to the ear, nose, throat specialist and he gave me Stugeron 75 mg and other antibiotics. I found the stugeron useful as the ringing noise has eased off a lot. I took it from 2 weeks. Then I went for a check up, and the Dr. prescribed me Fiaton ( Ginko biloba ), which is recommended for patiens suffering from Tinnitus. I have to take if for 20 days, and I was told that is going to repair the dammage on the ears. ( Not totally, but it will help ).

      I hope this can be helpful,

      Marielos
       
    7. arturito
      Buzzed

      arturito Member

      Tinnitus Since:
      11/2011
      hi,

      has anyone tried treatament with Cinarizine? Any conclusion?
       
    8. Stina
      Psychedelic

      Stina Member Benefactor

      Location:
      Tartu
      Tinnitus Since:
      11/13
      Ive been on Stugeron (Cinnarizine) for 3 days now (12,5 mg x 2 day). I have noticed that my tinnitus is more quiet but im not sure whether its in fact from the drug or simply because the drug makes me very sedated (my T is strongly relaetd to stress and anxiety). However I have noticed at night a sort of whooshing sound which wasnt there before. Since Cinnarizine is supposed to envigorate the bloodflow I think thats what has happened and in fact I think the blood flow in my ears has never been a problem. Has anyone else tried it and experienced smth like this before?
       
    9. Sameer advani
      Buzzed

      Sameer advani Member

      Location:
      New delhi
      Tinnitus Since:
      12/2011
      I tried taking stugeron forte half a tablet it worked a bit in suppressing my tinnitus ,, it was even more effective when I took it with alprax...gave me a good 10 hrs of sleep , but my brain feels a bit dull and I feel a bit drowsy ...but at the moment as I write this my t is less bothersome considering the fact ihad a crazy exposure to music and alcohol on Monday night as we celebrated my brothers 50 th birthday ..
       
      • Informative Informative x 1
    10. Asian

      Asian Member

      Tinnitus Since:
      4 weeks
      My Gp gave me this yesterday. He told me it may or maynot help my tinnirus but will definitely improve my vertigo. The combination is cinnarizine+dimenhydrinate
       
      • Agree Agree x 1
    11. 1MW
      No Mood

      1MW Member

      Cause of Tinnitus:
      ssnhl
      In my opinion the improvement (very minimal) of stugeron is less than side effects
      and this improvement and more can come with NAC.
      I have tried before it and for me is not helpful.
       
    12. undecided
      Fine

      undecided Member

      Location:
      Greece
      Tinnitus Since:
      04/2014
      Cause of Tinnitus:
      Unknown.
      I recently had some success by using Stugeron (cinnarizine), so I looked up the drug to see what's what.
      Here's an interesting snippet I found (from wikipedia):

      In treatment of nausea and motion sickness it was previously hypothesized that cinnarizine exerts its effects by inhibiting the calcium currents in voltage gated channels in type II vestibular hair cells within the inner ear.[6] However, more recent evidence supports the idea that at pharmacologically relevant levels (0.3µM–0.5µM), cinnarizine is not lessening vestibular vertigo by blocking calcium channels, but rather by inhibiting potassium (K+) currents that are activated by heightened hydrostatic pressure on the hair cells.[22] It is true that cinnarizine does abolish calcium currents in vestibular hair cells as well; it is just that this only occurs at higher concentrations of drug (3µM).[22] The inhibition of these currents works to lessen the vertigo and motion-induced nausea by dampening the over-reactivity of the vestibular hair cells, which send information about balance and motion to the brain.

      So we may have another potassium channel modulator.
      Which is weird, because Stugeron is a drug from the 50s.

      Anyway, I just thought I might share.
      Do keep in mind that Stugeron might have some quite nasty side effects such as causing Parkinsons (after heavy chronic use).
       
      • Informative Informative x 2
    13. cqman
      Pooptoast

      cqman Member

      Tinnitus Since:
      02/2013
      Useful information.

      I once tried flunarizine a calcium channels blocker, it did has some effect on me.
       
    14. Viking
      No Mood

      Viking Member Benefactor

      Location:
      Italia
      Cinnarizine always help me in dramatic moments. Always a great old drug without serious side. Effects!!! Most recommended
       
    15. skoupidis

      skoupidis Member

      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma or mvc
      I have tried it for 2 months straight, 150mg (2x75) daily. I took it 2 weeks after tinnitus onset. Didn't provide any releif, so I stopped. Tried to take again for 10 days 6 months after onset, did absolutely nothing again.

      Sideffects: It does give me a bad case of xerodermia and dandruff which stoped after I quit. Never had dandruff before.
       
    16. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Hm...I have really bad vertigo, so maybe I should try this?
       
    17. 1MW
      No Mood

      1MW Member

      Cause of Tinnitus:
      ssnhl
      If you have vertigo you must check the drugs you take.
      Vertigo is a signal for something bad happen to your inner ears.
       
    18. undecided
      Fine

      undecided Member

      Location:
      Greece
      Tinnitus Since:
      04/2014
      Cause of Tinnitus:
      Unknown.
      Hearing issues, when they first arise, are usually accompanied by some sort of minor vestibular troubles until the brain manages to compensate by other means. If they vestibular problems persist, maybe you should get a doctor's opinion.
       
    19. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Yeah, I might get some...Maybe this will help with tinnitus also, but who knows?
       
    20. cqman
      Pooptoast

      cqman Member

      Tinnitus Since:
      02/2013
      An animal study comparing the effectiveness of cinnarizine and flunarizine (a derivative of cinnarizine that is 2.5-15 times stronger [31] for treatment of transient global cerebral ischemia, it was found that cinnarizine helped to improve the functional abnormalities of ischemia, but did not help with damage to the neurons.[32] Flunarizine, on the other hand, offered more neuronal protection, but was less effective in treating subsequent behavioral changes.[32]
       
      • Informative Informative x 1
    21. Viking
      No Mood

      Viking Member Benefactor

      Location:
      Italia
      Cinnarizine/Stugeron help a lot of people who suffer of tinnitus and vertigo. It act suppressing the aberrant signal incoming from the labyrinth to the cns. Better combo is cinnarizine + dimenhydrinate (brand name, Arlevert, Arlevertan, ecc)

      http://www.tinnitusjournal.com/detalhe_artigo.asp?id=192

      http://www.tinnitusjournal.com/detalhe_artigo.asp?id=58

      http://www.tinnitusjournal.com/detalhe_artigo.asp?id=261

      better start dosage for tinnitus (only stugeron) 25mg x 3 always with full stomach (can be used for years and years exclusion for persons who have tremors or parkinson disease)

      After 1 week if it work go on 100x2 (Brekfast, dinner) full stomach

      For tinnitus + vertigo

      Arlevertan (cinnarizine 20mg + dimenhydrinate 40mg) 3 x day full stomach but with the limit of 30/60 days of usage.

      Cinnarizine in general is good for many type of tinnitus and it is the only drug that on the leaflet have the specific terapeutic indications: "ringing in the ears" It's a drug of 1957....mistery of medicines....

      No addiction, no serious side effects also at high dosage (100 x 2).

      Also better for sleep

      Best wishes
       
    22. mizzy3010

      mizzy3010 Member

      Hi.
      I have been suffering with T for about 2 mths now. Its driven me to the edge of madness and back again. Luckly i can ground myself by researching and i stumbled across this forum.

      Anyhow... 3 days ago i had a severe vertigo attack.. never expirenced anything like it. Was convinced i was having a stroke or something.. so the doc i saw has put me on Cinnarizine for the Vertigo.
      So 3 days later of 15mg tabs, 2 taken 3 times a day. I have noticed my T is quieter and my ears seem to be popping more...not sure if that connected or not.

      Im hoping that my vertigo attack will speed up my ENT appointment with the MRI request.
       
    23. valeri

      valeri Member Benefactor Team Awareness

      Location:
      Australia
      Tinnitus Since:
      09/2011
      What do you mean by dramatic moments?
      Why don't you take it every day?
       
    24. Xorthian
      Balanced

      Xorthian Member Benefactor

      Location:
      Poland
      Tinnitus Since:
      Initial 2012. Massive spike 4/2015
      Cause of Tinnitus:
      Noisey Lifestyle. Increase from infection.
      http://en.wikipedia.org/wiki/Cinnarizine#Side_effects
      acute/chronic - It is also of note that an estimated 17 of 100 new Parkinson's cases are linked to administration of either cinnarizine or Flunarizine,[1] making cinnarizine and drug-induced Parkinson's a serious issue.
       
      • Informative Informative x 1
    25. Viking
      No Mood

      Viking Member Benefactor

      Location:
      Italia
      Extreme loud tinnitus!
      Because after time and time...it loose effect.
       
    26. valeri

      valeri Member Benefactor Team Awareness

      Location:
      Australia
      Tinnitus Since:
      09/2011
      @Viking

      Does it work every time for reducing the volume?
       
    27. Viking
      No Mood

      Viking Member Benefactor

      Location:
      Italia
      Yes if you took it costantly it will work. Of course we are not equal, i'm talking about my past experience and then i dont want to give false hope to people who suffer.

      All the best
       
    28. valeri

      valeri Member Benefactor Team Awareness

      Location:
      Australia
      Tinnitus Since:
      09/2011
      I tried to pm you but not working.
      Are you please able to tell me the dosage you used and for how long it's used for t relief?
      Is this an ongoing intake or as needed?
      I understand this is your own experience so if you don't mind sharing it on forum or if you want you can pm me.
      Thanks!
       
    29. Viking
      No Mood

      Viking Member Benefactor

      Location:
      Italia
      I had started with normal dosage of 25mg x 3 always on full stomach. If you obtain benefit you can stay on this dosage for long time. If the benefit seem lower you can increase to 100mg morning + 100mg dinner always with full stomach. If after a week dont obtain benefit you can abandone it without risk of "wwithdraval" or others problems. It is well tollerated.
       
    30. valeri

      valeri Member Benefactor Team Awareness

      Location:
      Australia
      Tinnitus Since:
      09/2011
      Do you still use it?
       

Share This Page

Loading...
If you have ringing ears then you've come to the right place. We are a friendly tinnitus support board, dedicated to helping you discuss and understand what tinnitus treatments may work for you.