Unknown Clinical Trial of Acamprosate for Tinnitus

The first phase is an open-label screening study to identify subjects responding to acamprosate.

tinnitus forum
    1. Tinnitus Talk
      Balanced

      Tinnitus Talk Knowledge Base

      Tinnitus Talk submitted a new resource:

      Clinical Trial of Acamprosate for Tinnitus (version 1.0) - The first phase is an open-label screening study to identify subjects responding to acamprosate.

      Read more about this resource...
       
    2. 1MW
      No Mood

      1MW Member

      Cause of Tinnitus:
      ssnhl
      Have anyone tested acamprosate?
      Especially those that have benzos related tinnitus.
       
    3. Christian78
      Alone

      Christian78 Member

      Location:
      Gothenburg
      Tinnitus Since:
      (Sep 2013)
      Cause of Tinnitus:
      progressive tinnitus, time of expiring in next 3-6 months
      I have got a big box of this medicine and tested it and it did nothing FOR ME! Everyone is different (I use/d benzos)
       
      • Agree Agree x 1
    4. Aziz Khan

      Aziz Khan Member

      Tinnitus Since:
      November 2015
      What is benzo related?
       
    5. 1MW
      No Mood

      1MW Member

      Cause of Tinnitus:
      ssnhl
      Benzos related is T induced from benzodiazepine drugs.
      Benzos induce T more easily in people that has some form of hearing loss but no T.
      Also benzodiazepines withdrawal cause severe hyperacusis T and distorted hearing.
      Benzodiazepines induce high frequency T.
      Also people with genetic deficiency in benzodiazepines receptors without taking never benzos are more to develop T.
      In general benzos induced T tends to be severe because in unmaskeable.
      Benzos are life killer drugs with severe withrawal symptoms.
      In short term use at specific situations can save lifes
       
      • Agree Agree x 1
    6. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      I'll try to get some to see if it works for me..Could be a time limit, like AM-101? Maybe within the first year.
       
    7. Mark662
      Transparent

      Mark662 Member Benefactor

      Location:
      United Kingdom
      Tinnitus Since:
      1/1988
      I tried Campral a long time ago. It did nothing for my tinnitus, and made me very depressed. It caved my brain in.

      The trial was flawed and the resuls should never have been released, as subsequent trials showed the drug was totally ineffective for tinnitus

      No doubt it boosted sales of Campral for a while. It was the ultimate Red Herring.
       
    8. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      I did hear of some people finding their t to be lower due to campral, one ENT said that 4 out of 20 patients found relief, so not as high as the study, but the potential is there.
       
    9. Mark662
      Transparent

      Mark662 Member Benefactor

      Location:
      United Kingdom
      Tinnitus Since:
      1/1988
      4 out of 20 could be the sort of response with a placebo. I certainly wouldn't recommend trying it. The internet isn't showing any numbers having success with it either
       
    10. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Well, in that case we can say trobalt is an placebo effect. We could say any med is a placebo effect.
       
    11. Mark662
      Transparent

      Mark662 Member Benefactor

      Location:
      United Kingdom
      Tinnitus Since:
      1/1988
      I don't believe Trobalt's effect is placebo. At least it is a drug that is targeting the area of the brain that appears to be a hot spot for tinnitus, unlike Campral. If I could get my hands on Trobalt for a reasonable cost, I would be trying it
       
    12. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Prescription Medication

      If his patients have crossed his “magic line” of either affecting activities of daily living or interfering with sleep, and have not responded to the previous therapies, he offers prescription medications.

      1 – Xanax. He states that patients must use the real medication, not generics. He generally prescribes 0.5 mg, three times daily, for 4 months then conducts a follow-up appointment. This treatment helps, but does not cure, 78% of patients.

      2 – Baclofen plus Klonopin. He prescribes 10 mg Baclofen, three times daily, plus 1 mg Klonopin at bedtime. He finds that neither alone is as effective as both together. Baclofen is a muscle relaxant and an anti-spastic agent. It is also a selective GABA receptor drug and has been used in tinnitus trials with some success. Klonopin is a benzodiazepine derived anti-convulsant and anti-anxiety medication.

      3 – Neurontin or Lyrica. These are anti-epilepsy medications that work by increasing GABA uptake in the brain. GABA is the primary inhibitory neurotransmitter in the brain and helps decrease electrical activity. Increased electrical activity can lead to seizure, tinnitus and many other neurodegenerative conditions.

      Dr. Seidman is not a big fan of prescribing Neurontin and Lyrica because they require liver function tests and so he frequently sends these patients to a neurologist. When he does prescribe Neurontin, he starts with a low dose of 300 mg, three times daily, and has gone up to as high as 1200 mg, three times daily. He has seen success at both the low doses and higher dosage.

      4 – Campral. This is a medication that has recently been approved by the FDA for alcohol dependence. A clinical study in Brazil showed it reduced tinnitus in most patients. The study was very small and flawed in many respects but it still holds promise. Researchers surmise that it may act as a glutamate antagonist, a potential contributor to tinnitus. A discussion of glutamate antagonists and excitotoxins can be seen in our Tinnitus Library.

      Dr. Seidman has treated about 20 tinnitus patients with Campral and it has helped 3-4. He will use it if the patient requests it.

      5 – Memantine. This is another glutamate antagonist. Dr. Seidman says he has a 15% response rate.
       
      • Agree Agree x 1
    13. Mark662
      Transparent

      Mark662 Member Benefactor

      Location:
      United Kingdom
      Tinnitus Since:
      1/1988
      Neurontin (Gabapentin) is another drug that is banded about for t and clinically proven to be ineffective. Yes, I have tried that too.

      Xanax was effective when I took it, but soon built up a tolerance and was reluctant to increase the dosage.

      I think the scattergun approach by Dr Seidman and the drugs used are rather dated. Research has moved on.

      Everyone wants an existing off label drug treatment to be effective. It has yet to be discovered.
       
    14. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Well, I don't know, but we don't know if it can work for others. That's why I don't rule out anything.
       
    15. Mark662
      Transparent

      Mark662 Member Benefactor

      Location:
      United Kingdom
      Tinnitus Since:
      1/1988
      By all means, try everything and anything. I have done so for 25 years and nothing, apart from Xanax, has had any effect whatsoever, that is why medical science does not have the answer. It is one of the most complicated conditions to cure or even alleviate.
       
    16. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Get ye self some trobalt!
       
    17. Mark662
      Transparent

      Mark662 Member Benefactor

      Location:
      United Kingdom
      Tinnitus Since:
      1/1988
      :)
      I need a sympathetic GP
       
    18. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Yeah, don't we all? They are just scared they'd be struck off...

      Physicians in the United Kingdom can prescribe medications off-label. According to the British General Medical Council, off-label prescriptions must better serve patient needs than alternatives and must be supported by evidence or experience to demonstrate safety and efficacy.

      In the United States, no law prohibits a physician or other healthcare practitioner from prescribing an approved medication for other uses than their specific FDA-approved indications.

      So technically trobalt can serve as treatment for tinnitus than other drugs, therefore should be prescribed off label. There's loads of evidence trobalt works and is the best tinnitus treatment out there, so just keep going on and fight for it! Never give up I say. I made the argument that amitriptyline is used off label for sleep and tinnitus, but isn't licensed so technically they can prescribe trobalt off label.
       
    19. Mark662
      Transparent

      Mark662 Member Benefactor

      Location:
      United Kingdom
      Tinnitus Since:
      1/1988
      Did you get your GP to prescribe Trobalt?
       
    20. Christian78
      Alone

      Christian78 Member

      Location:
      Gothenburg
      Tinnitus Since:
      (Sep 2013)
      Cause of Tinnitus:
      progressive tinnitus, time of expiring in next 3-6 months

      1. addictive and loses effect after 3 months dosage must be increased

      2. same benzo loses effect after 3 months dosage must be increased

      3. they use lyrica it is medicine for neuro pains but it kills brain fast anyway the one that caused me worsening of tinnitus 200% may 2014.
      4.I used Campral it did not help ME, but we see it someone else try it, I am say to throw 150 pills in garbage

      5 i don't know anything about this thing Memantine
       
    21. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      She said, she'll call me back next week, so they are considering it.
       
    22. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Sorry to hear about that buddy.
       
      • Hug Hug x 1
    23. Mark662
      Transparent

      Mark662 Member Benefactor

      Location:
      United Kingdom
      Tinnitus Since:
      1/1988
      But you had relief from 3 x 400mg Trobalt, obtained from another source? am I right?
       
    24. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Yep.
       

Share This Page

Loading...
If you have ringing ears then you've come to the right place. We are a friendly tinnitus support board, dedicated to helping you discuss and understand what tinnitus treatments may work for you.