Differentiation and Transplantation of Human iPSC-Derived Otic Epithelial Progenitors in Mice

Discussion in 'Research News' started by mrbrightside614, Dec 15, 2019.

    1. mrbrightside614

      mrbrightside614 Member Podcast Patron Benefactor Advocate

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      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116394/

      “Human urinary cells isolated from a healthy donor were reprogramed to form iPSCs that were induced to differentiate into OEPs and hair cell-like cells...the induced hair cell-like cells displayed typical morphological characteristics and electrophysiological properties specific to inner hair cells. In vitro, OEP-derived hair cell-like cells formed synaptic connections with SGNs in coculture. In vivo, some of the transplanted cells migrated to the site of the resident hair cells in the organ of Corti, differentiated into hair cell-like cells, and formed synaptic connections with native SGNs.”​

      StemCells21 is planning to use IPSC’s by 2020.
       
      • Informative Informative x 2

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