Hi Dr. Nagler: I wrote to you back on 3/29/15 (https://www.tinnitustalk.com/thread...dache-medicine-that-may-impact-tinnitus.8901/) with a few questions. Since you have not replied, I'm guessing that my post (1) must have been too personal to my circumstances in contravention of some forums rules or (2) coincided with your own tinnitus spike and you're now behind in your usual forum activities. If it's #1, please let me know and I'll try in a new post to rectify any problems you have in responding by making my questions more general. If it's #2, then my apologies. I certainly don't want to be a nudge when you yourself aren't feeling well; it's just that I've seen some responses you've written to posts newer than the above-referenced post of mine and so I couldn't tell if mine maybe got lost somewhere. In any event, I hope you are coping better and thus feeling better these days. There's one further wrinkle regarding the medication prescribed for New Daily Persistent Headache (most of which seem to be the same as prescribed for chronic migraines. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444222/. During my two days on nortriptyline, my headaches, tinnitus and sleep were actually worse than before I started. So, I called the neurologist and asked to be taken off of it. I admitted, of course, that I sometimes get tinnitus spikes for no apparent reason and that while the headache is always there it varies in severity (again, without any apparent reason at times). I just tend not to be a big believer in coincidences. He took me off of it and a few days later prescribed Topamax (topiramate). So, I'd welcome your opinion on any or all of the following (keeping in mind that these meds are being prescribed for headache, not tinnitus, relief - I just don't want a permanent tinnitus spike or reduction in my already damaged hearing from drugs): (1) Do you have any advice for me to help me decide whether or not to take the topiramate? (2) I know that the list of meds often prescribed for NDPH and migraines is a long one and I sure don't expect you to be conversant with all of them from a tinnitus aggravation perspective, but do you perhaps have a short list of those you would counsel a person with hearing loss and tinnitus NEVER to take and/or a short list of those you would counsel such a person to try for headache relief b/c there's no evidence that they negatively impact hearing or tinnitus? (3) This may get lumped into #2, but I'll ask anyway. The NCBI paper cited above notes, "[a] significant proportion of NDPH sufferers may have intractable headaches that are refractory to treatment." Given the complications presented in prescribing headache meds for those who also suffer from hearing loss and tinnitus (and, yes, I am *suffering* right now) do you think this may be a case of "sucking it up and living with it" as far as the headaches go (pain scale ranges from 3-8 over the past 3+ months, and no days without a headache) and taking no meds for relief so as not to aggravate tinnitus or further impair hearing? ****** The pentoxifylline question from my original thread remains. ****** Many thanks, Dr. Nagler. I sincerely hope your re-habituation is proceeding well.