Hyperactive Neurons Linked to Alzheimer's

Hello,

Not sure if this has been discussed before, but I was randomly browsing the internet today and found this:

http://neurosciencenews.com/alzheimers-hyperactive-neurons-3416/

It hypothesizes a link between hyperactive neurons and the development of Alzheimer's. Seeing as Tinnitus is now thought of to involve hyperactive neurons as well, this might potentially put the "Tinnitus won't kill you" statement you often read in a whole new ballpark... (The statement is unbased anyway, because what do we really know about T and/or it's consequences? But thats another thing).

Of course there might be other factors involved in order to develop Alzheimer's, but it's not exactly a comforting read. Especially when considering the current state of affairs regarding scientific Tinnitus knowledge. Thoughts?

 

It would be surprising if this level of torture and sleep deprivation didn't lead to other serious conditions.

 

I was just thinking of the link between Alzheimer's and T, I was wondering if Aducanumab will be tested for T

 

From what I read Aducanumab works on the amyloid plaques, I'm not sure if it does something for hyperactive neurons. I guess we actually want to prevent the brain from creating these amyloid plaques in the first place.

 

Sure if T make you suffer it could lead to other neurological problems, but in general.. NO, T won't lead to alzheimer, just because hyperactive neurons means all and nothings. Depends which brain area is involved. Many different disease and disorders (and I bet something else non pathological) are linked to hyperactive neurons, also epilepsy, but it doesn't mean that T will lead to epilepsy, of course. It's also true that lifestyle affect several disease risks, including alzheimer, so just make sure to take care of your T avoiding to make it spiral down into depression or anxiety and you will be ok.

 

Thanks for your reply. I already thought the brain area is of much importance in regards to the Alzheimer link. I thought recent studies have shown that a lot of different brain areas can be involved in creating the Tinnitus perception through hyperactivity. Could it be that a link to Alzheimer (or perhaps other neurodegenerative diseases) could depend on the brain area the Tinnitus is generated in? The heterogeneity of Tinnitus might prevent making a direct causal link to Alzheimer's, but it might be that there's still a link depending on the etiology of the condition and the hyperactive brain areas involved.

• https://www.newscientist.com/articl...rain-reveals-multiple-regions-cause-tinnitus/
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886369/

Also, links between two other neurodegenerative afflictions (Epilepsy/Alzheimer) have been hypothesized before.

• https://www.sciencedaily.com/releases/2014/07/140722164128.htm

I'd appreciate your thoughts on this.

 

Many diseases share some underliyng mechanisms, as you know, in fact, many diseases share most symptoms. I would be very carefull to interpret the word "link", particularly with brain disorders which share some of several mechanisms but many others are different and unknown. I'm aware that T involves several hyperactive brain regions, mind that most of them are a consequence and not a cause of, it's a cascade effect. Most, if not every, brain activitiy work this way, a causal impulse (endogenous or exogenous, psychological, neurological or physical) triggers many others in different correlated areas. Studies have proven that a non T-group exposed to very loud sounds that are perceived as threatening will trigger most of the same areas that T does.
To my aknowledge, based on reading studies, states that most overlap with T is thalamocortical dysregulation , which is strongly linked to anxiety disorders, more than a cause-effect it's a mutual influence, in particular if I recall correctly the somatosensory focused obsession (can't find the study on ncbi). Mind that, as a symptom, T may have different causes, subgroups could share some hyperactive brain areas but it is not a clue about cause. For instance, focusing on treating-managing-curing anxiety or mood issue is usually of big help for every T sufferer, still just minority of this people will see their T disappear (or almost disappear), if it is because they didn't really fix their anxiety-mood D or not is impossible to know, but I would argue just that if hyperactivity is caused by anxiety issues, T could disappear since the cause has been fixed, but for others where the cause is different (i.e. hearing loss), treating anxiety and mood disturbance, which are naturally linked to T, could be of huge relief (lowering perception will make the sound lower, and it won't trigger mood or anxiety issue, which, in general is the culprit of suffering) but T won't disappear because these areas, in this case, are not the causal ones, so T will still persist even if hyperactivity in limbic system is addressed. Fortunately we have a good indirect control on modulating and training limbic system activity to some extent, even if it's very ancient, but unfortunately we don't have much control (or not at all) on other brain areas.
So, going back to your question, if T could lead to alzheimer or epilepsy, would mean that anxiety and mood disorders could lead to alz or epilepsy too. Well, I guess it's no more than a risk factor just as much as a wrong lifestyle can lead to these disorders and many other (i.e. obesity, cardiovascular, diabetes, and many other) based on individual predisposition, but the link is unlikely to be direct.

 

No, in that case tinnitus has more in common to Seizures.
there are user in her who has t for even 40 years
and never develop alzheimers.

 

My father had T lived to 88 and a couple uncles with T in the ninetys no memory problems............There is so much they do not no about T so Im not concerned about this....