Withdrawn/Terminated Intratympanic Steroid Treatment For The Prevention Of Inner Ear Toxicity Associated With Cisplatin

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Intratympanic Steroid Treatment For The Prevention Of Inner Ear Toxicity Associated With Cisplatin (version 1.0) - To determine if cisplatin ototoxicty can be prevented by intratympanic administration of steroids.

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https://clinicaltrials.gov/ct2/show/NCT01285674
Status: still unknown. Estimated study completion date: January 2012. I did not find any results on the net about this clinical trial. I sent an e-mail today to Peter Gilbey, the contact of the clinical trial, to ask for the results.

I only find results about a similar study on mice:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720789/

 

Peter Gilbey kindly replied me today:

Dear Frederic

I'm sorry to inform you that this study was never performed.
I would, however like to refer you to a study by Prof. Shupak:
Prevention of Cisplatin-Induced Hearing Loss by Intratympanic Dexamethasone: A Randomized Controlled Study.
Marshak T, Steiner M, Kaminer M, Levy L, Shupak A.
Otolaryngol Head Neck Surg. 2014 Jun;150(6):983-90. doi: 10.1177/0194599814524894. Epub 2014 Mar 11.
Perhaps this will be of help.
Best of luck,

Peter