NAD+ Enhanced on Hearing Recovery in Sudden Sensorineural Hearing Loss: Randomized Controlled Trial

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NAD+ Enhanced on Hearing Recovery in Sudden Sensorineural Hearing Loss: Randomized Controlled Trial

The study with 38 participants (average age 41.74 years, 78.98% male, 42.11% right ear, average Pre-PTA 76.88 dB HL) showed that the NAD+ group experienced significantly greater hearing improvement (40.21 dB HL) compared to the control group (23.06 dB HL, t = 2.722, p = 0.010). The effective rate was higher in the NAD+ group (94.44% vs. 60.00%, Z = −3.014, p = 0.003). Significant group × time interactions were noted in the NAD+ group (F = 2.867, p = 0.030), with greater improvements from 7 days to 3 months post-treatment. Recovery time was shorter in the NAD+ group (62.97 vs. 175.98 days, p = 0.028). Tinnitus and aural fullness improved more in the NAD+ group, especially after 3 months. Higher pre-treatment tinnitus and aural fullness scores were linked to better outcomes with NAD+ for SSNHL.

NAD+ was more effective in improving hearing and reducing recovery time in SSNHL patients and also benefited tinnitus and aural fullness management.