Nortriptyline and Terrible Spike?
- Thread starter Eleanor
- Start date
Member
Sadly yes it can cause a spike or worsening. ..Discontinue if you can. I have it and never tried it.
I know one person who's spike went away...and still (I believe) takes it.
I know one person who's spike went away...and still (I believe) takes it.
The issue is, the drugs that do lower tinnitus in studies are ototoxic. The only alternative is trobalt and that's not safe. So how can we win?
A randomized trial of nortriptyline for severe chronic tinnitus. Effects on depression, disability, and tinnitus symptoms.
Sullivan M1, Katon W, Russo J, Dobie R, Sakai C.
Author information
Abstract
OBJECTIVE:
To determine whether the antidepressant, nortriptyline, is effective for treatment of depression, tinnitus-related disability, and tinnitus symptoms in patients with severe chronic tinnitus.
DESIGN:
A 12-week, double-blind, randomized controlled trial.
SETTING:
A university otolaryngology clinic.
PATIENTS:
Ninety-two subjects with severe chronic tinnitus: 38 with current major depression and 54 with depressive symptoms and significant tinnitus-related disability.
INTERVENTION:
Nortriptyline (maintained at 50 to 150 mg/mL for 6 weeks) or placebo.
MAIN OUTCOME MEASURES:
Hamilton Depression Rating Scale, Tinnitus Disability Measures, and Audiometric Measures.
RESULTS:
Nortriptyline was superior to placebo by multivariate analysis of covariance for depression (10.6 vs 14.3 final Hamilton Depression score), for tinnitus-related disability (1.8 vs 2.4 final MPI Tinnitus Interference), and tinnitus loudness (13.6 vs 20.0 dB final loudness match [in worst ear at tinnitus frequency]). When major depression and depressive symptoms groups were considered separately, nortriptyline was superior to placebo on these same measures but differences did not achieve statistical significance.
CONCLUSIONS:
The antidepressant nortriptyline decreases depression, functional disability, and tinnitus loudness associated with severe chronic tinnitus. What appears to be irreversible disability of otologic origin may, in part, be reversible disability of psychiatric origin.
http://www.ncbi.nlm.nih.gov/pubmed/8215728
I was given nortriptyline for chronic pain and my tinnitus has spiked -- my doctor has suggested gabapentin as a substitute for the nortriptyline -- any issues with gabapentin and tinnitus?
Florida John
Member
- Dec 14, 2016
- 110
- Tinnitus Since
- 1999
- Cause of Tinnitus
- noise, and possible head trauma
I have had T for over 20 years,,I learned to live with it, I know now that I was able to live ok with it because it was low, recently I came off Gabepentin too fast and had a bad withdraw and now my tinnitus is very bad (going on 6 weeks) since my doctor said it was safe, I thought nothing of it, started feeling bad went to the Emergency Room, and at that point did not know what caused it, they did blood test said I had bacteria infection,,,calmed my extreme anxiety down with ativan,,,sent me home with antibiotics, took them and made things worse, that was 6 weeks ago, still struggling, even wanting to end it all, I am fighting for my life from something that cant kill me, the noise is extremely loud, I have very bad high frequency hearing loss,,I have tried hearing aids in the past but could not adjust, because they made every noise even louder, thats what they do, I believe I also have Hypercausis too, life is a real mess. I was on gabepentin at lower dose with no problem, but went up on dose for nerve pain, but felt bad and so came off it (Way too quick) and the damage was done, life has changed for the worse,,this morning I took L-Theanine (Supplement), and it made me feel relaxed, but as the day went on tinnitus got louder,,,,trying to calm down,,,I have been fighting taking ativan, as I dont want to get addicted to it,,I think I am venting,,,,hope this helps
