Serotonergic Regulation of Excitability of Principal Cells of the Dorsal Cochlear Nucleus

Discussion in 'Research News' started by Stink, Mar 18, 2015.

tinnitus forum
    1. Stink

      Stink Member

      Location:
      US
      Tinnitus Since:
      09/2000
      http://www.jneurosci.org/content/35/11/4540.abstract

      The dorsal cochlear nucleus (DCN) is one of the first stations within the central auditory pathway where the basic computations underlying sound localization are initiated and heightened activity in the DCN may underlie central tinnitus. The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT), is associated with many distinct behavioral or cognitive states, and serotonergic fibers are concentrated in the DCN. However, it remains unclear what is the function of this dense input. Using a combination of in vitro electrophysiology and optogenetics in mouse brain slices, we found that 5-HT directly enhances the excitability of fusiform principal cells via activation of two distinct 5-HT receptor subfamilies, 5-HT2A/2CR (5-HT2A/2C receptor) and 5-HT7R (5-HT7 receptor). This excitatory effect results from an augmentation of hyperpolarization-activated cyclic nucleotide-gated channels (Ih or HCN channels). The serotonergic regulation of excitability is G-protein-dependent and involves cAMP and Src kinase signaling pathways. Moreover, optogenetic activation of serotonergic axon terminals increased excitability of fusiform cells. Our findings reveal that 5-HT exerts a potent influence on fusiform cells by altering their intrinsic properties, which may enhance the sensitivity of the DCN to sensory input.
       
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    2. skoupidis

      skoupidis Member

      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma or mvc
      Ok, someone translate please!
       
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    3. 1MW
      No Mood

      1MW Member

      Cause of Tinnitus:
      ssnhl
      this can explain the otoxicity of andidepressants that act on serotonine
       
    4. ruben ruiz

      ruben ruiz Member

      Location:
      Tucson, AZ
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      I believe it was meds and stress
      Most doctors dont know squat about T an H. There passing out ototoxic meds like candy.
      Gotta be your own dr.
      Learn quick! I always thought SSRI were bad for me. I think they caused my problem along with Cipro. I prefer benzos
      you take them when you need them.
       
    5. tdn

      tdn Member

      Tinnitus Since:
      05/2012
      Cause of Tinnitus:
      Trittico / Trazodone
      There's a bit more text on this subject here: http://www.jneurosci.org/content/35/11/i.full#sec-2

      #Our findings reveal that 5-HT exerts a potent influence on fusiform cells by altering their intrinsic #properties, which may enhance the sensitivity of the DCN to sensory input.

      Welp, so that's what trazodone most likely did to me: permanently changed the properties of (or damaged) some cells/neurons/whatever in my brain that were responsible for blocking out a current (the phantom sound) that was never intended to reach my consciousness.

      Why exactly are anti depressants still not banned? Oh, big pharma making big bucks. Got it :p
       
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    6. DebInAustralia

      DebInAustralia Member Benefactor Team Research

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      Benyru mentioned serotonin depletion was linked to potassium channel closure.
       
    7. lapidus

      lapidus Member

      Location:
      Sweden
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Noise induced
      Yeah, that could explain why some doctor cured a patient's hyperacusis with Fluoxetine. That's a serotonin reuptake inhibitor that opens block on Kv3.1 potassium channel. But on the other hand I'm sure that one is also reported ototoxic somewhere. Sigh.
       
    8. linearb
      Psychedelic

      linearb Member Hall of Fame

      Location:
      East Coast USA
      Tinnitus Since:
      1998
      sounds like in a few years they will be able to fix tinnitus with optogenetics. Meaning, they inject you with a synthetic retrovirus which permanently rewrites the DNA of DCN cells to include a photoresponsive protein, and then when your ear ringing pisses you off, you shine a blue light over the back of your head and it all quiets down...
       
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