Steroids: Prednisone / Dexamethasone / Others (Oral and Injections)

Discussion in 'Treatments' started by tweak, Apr 23, 2012.

    1. Rings-a-Bell

      Rings-a-Bell Member

      Location:
      Barbados
      Tinnitus Since:
      April 2016
      Cause of Tinnitus:
      Accoustic Trauma
      No... never heard of it... have you tried it for your T?
       
      • Good Question Good Question x 2
    2. Rings-a-Bell

      Rings-a-Bell Member

      Location:
      Barbados
      Tinnitus Since:
      April 2016
      Cause of Tinnitus:
      Accoustic Trauma
      Got the puffy face but I never felt like it affected my emotions or thinking. Little rough on the stomach too as I recall...
       
    3. Virginia1027

      Virginia1027 Member

      Tinnitus Since:
      August 2013
      My doctor is recommending prednisone. I've read so many conflicting things about prednisone and tinnitus.

      Can somebody help me out?
       
    4. Renka

      Renka Member

      Tinnitus Since:
      March 2018
      Cause of Tinnitus:
      perindopril
      I did dexamethasone several times intravenous and topical. I must say it works in reducing tinnitus, but it has also side effects. I got a deep vain trombosis and a pulmonary embolism as a result. That is why I think systemic administration of steroids is a bad idea. Topical dex through a microwick did wonders for me.
       
    5. Liam_Cairns

      Liam_Cairns Member

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Originally loud Music and was worsened by Micro-suction
      Hey I just thought I should share my experience with prednisone as a cautionary tale,

      I took a course of prednisone for an acoustic trauma back in May and it left me crippled for a few months. It wasted all the muscle in my legs, I could barely walk without experiencing violent cramping and have only now just gotten back to being able to run after months of rehab.

      While I truly believe this drug can help with some people's tinnitus, I think people need to be incredibly cautious about weighing up the risks, especially since this can cause vascular necrosis even after short-term treatment, which is truly awful.
       
      • Agree Agree x 1
      • Informative Informative x 1
    6. Eric N

      Eric N Member Benefactor

      Location:
      Montreal QC
      Tinnitus Since:
      10/2012, 03/2016, 05/2017, 05/2018
      Cause of Tinnitus:
      noise + 3 major increases via (shouting / MRI/ flu+Tylenol)
      Did it help you?, I am currently only 15 mg and it makes me feel awful
       
    7. Liam_Cairns

      Liam_Cairns Member

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Originally loud Music and was worsened by Micro-suction
      for my acoustic trauma it did nothing tinnitus wise,however it prevented hyperacusis from developing
       
    8. kmohoruk
      Nerdy

      kmohoruk Member Benefactor

      Tinnitus Since:
      07/2005
      Cause of Tinnitus:
      Loud Noise, Ear Infection, TMJ
      Hello everyone,

      I had a question regarding prednisone and the appropriate dosing for acoustic trauma. Long story short, I had to figure this all out within the past couple days, and I am still trying to sort all the details. Any sort of help with this would be greatly appreciated. Here is my full story from the past two days.

      I have been taking 50 mg of prednisone for about 3 days and have seen some small improvements (hopefully it's not temporary). I was given an extension on my prescription and was given an additional 4 days of the 50 mg.

      My ENT said that 7 days is the maximum that you want to take that dosing of prednisone for before tapering off is necessary.

      Is taking that volume of prednisone for a whole week a good idea? I was also debating possibly holding onto some prednisone from this prescriptions for possible future acoustic trauma.

      I know a lot of this is advice, but I am just trying to figure out myself if I want to finish this prescription early or maybe end it a bit early if there is a risk of possibly aggravating my tinnitus or hyperacusis. This is all just very new to me as I usually don't take any real medication besides the odd Advil.

      Thank you very much!
       
    9. Liam_Cairns

      Liam_Cairns Member

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Originally loud Music and was worsened by Micro-suction
      It should be okay, but please be careful about getting into a cycle of dosing prednisone after every noise exposure, I know myself and many others became trapped in this cycle.
       
    10. kmohoruk
      Nerdy

      kmohoruk Member Benefactor

      Tinnitus Since:
      07/2005
      Cause of Tinnitus:
      Loud Noise, Ear Infection, TMJ
      Thank you very much for your thoughtful concern @Liam_Cairns , I greatly appreciate it! I only plan on using prednisone for more serious acoustic exposures. If anything, taking a high dose of prednisone freaks me out a lot - so I GREATLY appreciate everyone’s help with trying to figure out a good dose without causing any more issues. :)

      In this case, the boat horn last week was probably my most serious acoustic exposure since the original onset of my increased T. One where it left me with a longer term spike (they usually settle after a day or two for me).

      I have also had some issues sleeping (about 4 hours a night) the last couple of weeks (even before the acoustic shock of the boat horn last week), so hopefully with some rest, sleep, and prednisone - my spike starts to come back down.
       
    11. derpytia
      Pooptoast

      derpytia Member Benefactor

      Location:
      Rescue, California
      Tinnitus Since:
      04/2014
      Cause of Tinnitus:
      Hearing loss / ETD
      Should I take prednisone?

      I was leaving work tonight and someone pulled out a shopping cart near me and it made a loud clanking noise (it's got metal parts) in my left ear. Only lasted for less than a second but I'm not sure how loud it was in decibels.

      I came home and plugged my ears to listen. No new sounds but I can quite tell if my high pitched "eee" is more pronounced or if it's just a spike from the anxiety that almost overwhelmed me and made me almost panic. That ear has definitely been louder one days I don't get enough sleep. But I seriously cannot tell if I should take one of the prednisone pills I have on hand just in case. I only have a 24 hour window to make this decision. It happened at 8:00 pm this evening and it is now 10:58 pm while I'm making this post.

      (Bill Bauer, I respectfully request you do not interact with this thread, thank you!)
       
      • Good Question Good Question x 1
    12. derpytia
      Pooptoast

      derpytia Member Benefactor

      Location:
      Rescue, California
      Tinnitus Since:
      04/2014
      Cause of Tinnitus:
      Hearing loss / ETD
      lol frig it. I took one 5 mg pill just in case. I'll go to bed tonight and see what tomorrow brings.
       
      • Like Like x 1
    13. annV
      Fine

      annV Member

      Tinnitus Since:
      2005
      Cause of Tinnitus:
      unknown - possibly hereditary
      Did it help? How are you now after waking up?
       
    14. derpytia
      Pooptoast

      derpytia Member Benefactor

      Location:
      Rescue, California
      Tinnitus Since:
      04/2014
      Cause of Tinnitus:
      Hearing loss / ETD
      Well I don't know if it was the prednisone that helped or sleep. Woke up to my normal severe tinnitus. So that's good at least.
       
      • Hug Hug x 1
    15. Arseny
      Wishful

      Arseny Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Possibly from problems with blood flow
      Hello everyone,

      I will be very honest with you that I couldn't make myself to read though every comment in this thread, because I freak out the moment I see that someone got bad side effects. It scares me the most.

      I would like ask anybody that got similar treatment to tell me if their dosages were similar to mine.

      After the spike on November 2 I've got a single 90 mg Prednisone injection that gave me very bad panic attacks and I think spiked the noise even more, but in the following days the noise has definitely gone down and my right ear has improved. The improvement in my right ear is undeniable.

      A week later doctor decided to put me on Dexamethasone with
      4 mg - skip a day - 8 mg - skip a day - 8 mg - skip a day - 8 mg - skip a day - 8 mg - skip a day - 4 mg.
      6 injections in total.
      Previously she prescribed 90 mg of Prednisone everyday for 5 days, but since I've got sever panic attacks from it I had to stop.
      She said that 4 mg of Dexamethasone is equal to 30 mg of Prendisone. So right now I'm supposedly getting the equivalent of 60 mg of Prendnisone every other day.

      I'm not sure that my dosage is adequate since I've read a couple of studies and they administered the steroids every day without skipping anything and in one study I found that they gave 40 mg of Dexamethasone for 3 days and then 10 mg for 3 days.

      Please if you have been getting similar treatment or have knowledge in this topic I would ask you to evaluate my dosage and injection regimen. It seems to me that I should be getting everyday injections with a higher dosage although I'm not sure. I really don't want to discover later that my doctor has under dosed me in fears of side effects. I'm not experiencing any side effects on Dexamethasone and I'm ready to increase the dosage if necessary. I can also switch back to Prendnisone since my nervous system has somewhat stabilized.

      Thank you
       
    16. Arseny
      Wishful

      Arseny Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Possibly from problems with blood flow
      Hello again,

      After discussing the dosages with my doctor we decided to start doing injections everyday for at least 2-3 days more to see if there's any difference.
      Right now I'm on 8 mg a day of Dexamethasone.
      I've noticed that the volume in my left ear fluctuates by a lot.
      After single Prednisolone injection a had a decrease in volume couple of days later. To the point that I needed to concentrate on the hiss when I was pouring the water from water dispenser. But for some reason it has gone up again and it fluctuates by 20-30%.
      I'm not sure if Dexamethasone is doing anything significant. The only thing that I can notice is that low frequency sound with feelings of pressure on my ear drum are mostly gone. It was there yesterday, but right now it's completely gone and I can hear slight ringing (1-2/10) and very loud high frequency hissing noise in the left side of my head that feels like it's affecting other parts of my head. It has slight pulsations too. The volume is loud and I can hear it over my PC fan to the point I don't really hear the fan. I think it's about 60 db in comparison to other noises. I hope it gets better. I'm feeling very distressed right now.

      If everyday administration of Dexamethasone doesn't yield any significant improvements I will try intratympanic injections or switch back to Prednisolone. I want to try everything before starting HBOT treatment in 8 days.

      How much time do you think I should give steroids to work?
      I've read through this thread and some people report immediate improvements while others suggest that steroids need time to work.
       
    17. Arseny
      Wishful

      Arseny Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Possibly from problems with blood flow
      I wanted to share an update regarding my Dexamethasone injections.

      2 days after I finished the treatment I have my allergies flare up again and symptoms of pulsating pressure on my left eardrum have returned although they have been diminished by about 50%. The Morse code/ringing tinnitus in my left ear is a bit quieter too. Actually I think it's still improving a bit.
      I don't think there have been any noticeable change in volume of the hissing noise.

      I've been to numerous specialists at this point, every one of them thinks I have different diagnosis. Several of them suggested that I have ETD and, since during the steroid treatment feelings of fluttering/pressure/fullness went away, I might agree with them, but I think it's very mild.

      At this point there's almost no doubt that my mild/moderate tinnitus has been severely aggravated by 15 minutes of noise exposure from MRI. I still can't accept the reality.
       
    18. Tim Lawlor

      Tim Lawlor Member

      Tinnitus Since:
      February 2017
      Cause of Tinnitus:
      Unknown
      One note of EXTREME caution. I was prescribed Prednisone by an ENT doctor for two weeks relatively early after the ringing started. The prednisone apparently compromises your immune system. At the end of two weeks, while beginning to taper, I got what I thought were withdrawal symptoms. They were not -- my compromised immune system allowed a virus to infiltrate my nervous system and I was hospitalized for two weeks with Aseptic meninges encephalitis. This was a very close call -- two weeks in the hospital, two more in a rehab inpatient hospital, and six weeks of out patient rehab. After that, my tinnitus is apparently a permanent fixture. It may be related to TMJ issues I'm also having, but haven't returned for medical attention again yet -- a near fatal infection was enough for me for a while.
       
      • Informative Informative x 2
    19. RichardGuy
      Depressed

      RichardGuy Member

      Location:
      Florida
      Tinnitus Since:
      10/16/17
      Cause of Tinnitus:
      Acute
      I strongly recommend prednisone to anyone who thinks they are good for it. I've tried pred packs and they generally aren't enough... then I went to an 8 day taper course starting at 40mg. So 40 mg per day for two days, then 30, then 20... etc.

      I had one of the quietest weeks ever since I got tinnitus.. the ringing was so quiet I could even forget about it while trying to sleep. Still a 3/10 for annoyance, though far less than the usual 7.5/10.

      Once I dropped down to 10mg though I went back to baseline. So clearly a strong dose (for your weight) is needed.
       
    20. Marko Nakovski
      Bored

      Marko Nakovski Member Benefactor

      Location:
      North Macedonia
      Tinnitus Since:
      27.04.2017
      Cause of Tinnitus:
      Loud music
      Do steroids work for hyperacusis too?
       
    21. IvanRus

      IvanRus Member

      Tinnitus Since:
      04/2017
      Cause of Tinnitus:
      ototoxicity
      Do you think a dose of prednisone 40 mg per day for three days is sufficient?

      Is it dangerous to immediately cut off such a dose? Suddenly the cochlear inflammation will flare up with a new baseline after such a short course and a quick withdrawal?

      What do you think? Need a longer course?
       
    22. Bart
      Doh

      Bart Member

      Location:
      Antwerp
      Tinnitus Since:
      05/06/2014
      Cause of Tinnitus:
      2014 Noise / 2018 ototoxic meds
      According to my ENT and the doctors at the tinnitus clinic those short courses are useless, for it to work optimally with permanent results you need to take them for at least a week.

      The standard dose prescribed to me goes as follows: 64 mg for 3 days - 32 for 3 days and 16 for 3 days.

      That has worked well for me in the past, 64 mg is an extremely high dose though and will give some side effects, but overall not too bad. Those relative short doses of a week or 9 days are pretty safe.

      They also mentioned that they have seen some good results up to 3 months (!) after onset from steroids, although the sooner the better still stands, after 1 month positive results dropped significantly to stop completely after the 3 month mark.

      Typical side effects are insomnia , sweating and restlessness but stop after you finish the steroids , just take some sleeping aid the first days, especially with the 64 mg. It is a pretty heavy duty drug but it works.
       
    23. IvanRus

      IvanRus Member

      Tinnitus Since:
      04/2017
      Cause of Tinnitus:
      ototoxicity
      Does prednisolone really work for you?

      Did you take it for tinnitus spikes?

      What else do doctors prescribe in Belgium, except for prednisone in such cases?
       
    24. Bill_
      Insomnious

      Bill_ Member

      Location:
      Germany
      Tinnitus Since:
      04/1998
      Cause of Tinnitus:
      1. loud Concert | 2. loud club | 3. tympanometry
      The problem with these oral regimen of steroids is that when compared to a control group they really do not make any statistically significant difference. There was a meta study in 2017 done by German health insurances in which they analyzed all available studies on oral steroids for SSNHL and the conclusion was that it really doesn't make a difference. Yet some doctors will tell you to take them immediately. Personally I do believe that the only effect it might have is due to placebo if your tinnitus is actually caused by an inflammation.
       
    25. Bart
      Doh

      Bart Member

      Location:
      Antwerp
      Tinnitus Since:
      05/06/2014
      Cause of Tinnitus:
      2014 Noise / 2018 ototoxic meds
      It depends, when they suspect hearing loss in the acute stages they will prescribe steroids and HBOT, Rivotril (clonazepam) combined with Deanxit was prescribed to me as well when the steroids and HBOT failed initially.
       
    26. Bart
      Doh

      Bart Member

      Location:
      Antwerp
      Tinnitus Since:
      05/06/2014
      Cause of Tinnitus:
      2014 Noise / 2018 ototoxic meds
      I can only speak from my personal experience and when I take steroids it seems to calm down spikes every time, but indeed, how much of this can be attributed to the steroids or if it would have come down regardless is hard to say.

      My ENT said they prescribe steroids just to be sure, sometimes there is inflammation or swelling that is hard to see, the exact mechanism on why or how it would work is unclear to me, but from my understanding when you suffer sudden hearing loss or damage to the auditory system the body responds with inflammatory responses that can make the damage permanent, not sure about this theory though ;-)
       
    27. IvanRus

      IvanRus Member

      Tinnitus Since:
      04/2017
      Cause of Tinnitus:
      ototoxicity
      And each time you use this “brutal” regimen - 65-65-65 mg and then with a decrease during the week? Or are there smaller and shorter regimens?
       
    28. Bart
      Doh

      Bart Member

      Location:
      Antwerp
      Tinnitus Since:
      05/06/2014
      Cause of Tinnitus:
      2014 Noise / 2018 ototoxic meds
      Again it depends , sometimes I use 2-2-2 days , so 64-64-32-32-16-16 , or I switch it up , for example, 2 days at 64 , 4 days 32 and 2 or 3 days at 16 mg .

      The 64 mg gives some side effects wich can be unpleasant , so I try to limit the days on those high doses . Be advised, the first day your tinnitus can spike dramatically from the steroids but it is temporary .

      According to my GP , the really bad long term adverse effects from this drug only happens when you are on it for months at a time, or even years , the short courses are pretty safe .

      This is just my personal opinion and based on what my own ENT and GP are saying , every person is different though so always use it with caution and under supervision of a Healthcare proffesional .
       
      • Like Like x 1
    29. Trish S

      Trish S Member

      Location:
      Edinburgh
      Tinnitus Since:
      1967
      Cause of Tinnitus:
      Meniere's Disease
      I have not had oral steroids, but have had 3 trans-tympanic injections of dexamethasone at intervals during last year: this was for Meniere's Disease. It has reduced the frequency, severity and duration of the dizzy turns - not quite abolished them, but they now only last for a few seconds or minutes and don't throw me off my feet any more! Unfortunately the injections haven't helped the tinnitus, and my hearing continues to deteriorate.
       
      • Hug Hug x 1
    30. Daniel Lion
      Ape-like

      Daniel Lion Member Benefactor

      Location:
      se asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      This condition is awful, as we all know.

      Was riding my bike, a truck blasted me with a horn at point blank range. Absolutely crapped myself, went and bought steroids and self-medicated myself at 80mgs a day of prednisone.

      You can by any drug here without a script, third world. Anyhow, prior to tinnitus and ear trauma, i would never pop pills, but things are different now. Didn't feel a damn thing, not unusual for me, and annoying base line pitch is still exactly the same. Glad i did it for the placebo effect and I think it is not possible to protect 24/7 in the city. Too many cars and industry. Just wanted to inform you all.
       

Share This Page

Loading...