Steroids: Prednisone / Dexamethasone / Others (Oral and Injections)

Discussion in 'Treatments' started by tweak, Apr 23, 2012.

    1. Alue
      No Mood

      Alue Member

      Tinnitus Since:
      01/2016
      Cause of Tinnitus:
      Acoustic Trauma
      Did your legs recover fully? Avascular necrosis is one of my biggest concerns with prednisone use. I thought it was most commonly seen in people that use it on a long term basis or frequent short term with high dosages, but maybe I'm mistaken. It's rare, but it's a horrible side effect.

      I wonder if pentoxifylline or Vitamin E would help reduce the risk.
       
    2. Liam_Cairns

      Liam_Cairns Member

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Originally loud Music and was worsened by Micro-suction
      Hey @Alue I did mainly recover in that I don't get any more pain, but my quads are still very weak and my left knee doesn't track properly so it constantly cracks, which is a sign that my quads still need strengthening. Additionally I took a single dose back in the start of this month when I freaked out about my tinnitus and it caused an insane amount of pain all thru my legs, so I immediately stopped.

      Also I asked my Ent about that and he said statins could possibly help along with vitamin E as the mechanism of AVN is related to high cholesterol induced by the Prednisone. However statins can also be ototoxic so it's a bit of a shit show hahaha (classic tinnitus), transtympanic steroids can prevent AVN from occurring as well. I hope this was helpful.
       
    3. Alue
      No Mood

      Alue Member

      Tinnitus Since:
      01/2016
      Cause of Tinnitus:
      Acoustic Trauma
      Thanks. Do you think the pain was caused by avascular issues or something else? Did you talk with a doctor about it or get any scans done?
      I've taken steroids a few times in the past, like you when freaking out about loud noise exposure (I have very reactive tinnitus and have developed new tones from additional noise exposure), but I'm starting to second guess the wisdom in doing this.
       
    4. Arseny
      Wishful

      Arseny Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Possibly from problems with blood flow
      @Alue @Liam_Cairns
      I had lost a lot of muscle on dexamethasone.
      I had 3 courses in 2 months.
      I was going to the gym before that so the difference is quite noticeable. It was definitely induced by steroids since you can't lose that much muscle in less than 5 days even if you don't eat anything.

      Doctors say that's normal and to be expected with steroids.

      I can't really say if it was a coincidence or not, but with steroids and HBOT hyperacusis got much better (and then slowly faded away to zero until I got exposed to the noise again) and tinnitus got a bit quieter.
      After a week of HBOT I noticed ~25% reduction, but later I got more noise exposure again.
       
    5. Liam_Cairns

      Liam_Cairns Member

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Originally loud Music and was worsened by Micro-suction
      @Alue I got an MRI of my knees and hips (quiet MRI thank god) and it showed runners knee but no AVN thank god, apparently, MRI is like the only way to diagnose it in the early stages, which is important as the faster you can treat it the better. Yeah I am also starting to question the efficacy of steroids to be honest if you don't mind me asking Alue, what is your hearing like? Do you have any damage in normal or Ultra High frequencies?
       
    6. Liam_Cairns

      Liam_Cairns Member

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Originally loud Music and was worsened by Micro-suction
      Yeah, muscle loss is common, especially with fluorinated steroids such as dexamethasone, did you get steroids for your hearing loss, or something unrelated? As I have never really heard of oral dexamethasone being used for tinnitus.
       
    7. Alue
      No Mood

      Alue Member

      Tinnitus Since:
      01/2016
      Cause of Tinnitus:
      Acoustic Trauma
      I have damage in the ultra high frequencies, no detectable damage in normal frequencies.

      Where did you find a quiet MRI? I'm afraid of ever doing one because of all the stories with people getting worse from them.
       
    8. Liam_Cairns

      Liam_Cairns Member

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Originally loud Music and was worsened by Micro-suction
      And I'm guessing your main tinnitus is in the UHF? Sorry for the random questions. Also, I found one at a hospital near me in Brisbane Australia, I used a Toshiba Vantage Titan 3T, the Toshiba ones are the only ones I would use if I was you as they have a vacuum chamber surrounding the magnet which significantly reduces noise produced. Look for machines with "pianissimo" technology. I will say tho, that the machine still produces a lot of bass as it scans, so it will still seem loud. They max out at 90 dba however I reckon the dbc figure would be much higher as it doesn't take into account the lower frequencies, but in saying that a normal MRI can go up to around 115 dba so it is far less loud. Apologies for the huge info dump, feel free to personal message me if you need any additional help finding an MRI just so it doesn't clog up the thread, I would be more than happy to help.
       
      • Informative Informative x 3
    9. Alue
      No Mood

      Alue Member

      Tinnitus Since:
      01/2016
      Cause of Tinnitus:
      Acoustic Trauma
      Yep. My main tone is ultra high frequency. I have a couple other tones that are also fairly high in frequency. What about you?

      Thanks for the advice on MRIs. I'll keep that in mind if I ever need one.
       
    10. Liam_Cairns

      Liam_Cairns Member

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Originally loud Music and was worsened by Micro-suction
      Yeah mine is in the UHF, but I have no hearing loss I can hear up to 19 k at 5db and have been retested twice, man tinnitus really works in mysterious ways. But yeah if you have any more question seriously hmu just cause I would hate to see you get a worsening from something like that
       
    11. Danton

      Danton Member

      Tinnitus Since:
      12/2018
      Cause of Tinnitus:
      Loud ear phones.
      Hey liam, I live in the brisbane area and was wondering which clinic had that quiet MRI, I've been having funny feelings in my left hip 4 weeks after doing a week course + taper predniosone 6 days after noise exposure, I was doing insanely well until, 3 days ago where I went to a moderalty loud party with ear protection, and woke up with a raging buzz, I got scared and it didn't really improve this morning so in my weakness I took a 64mg dose of prednoisone, I realize that was a mistake, How high of a dose did you take that you stopped cold turkey from?, Does anyone know if I should take 30 tomorrow, then 14 to taper off or just stop cold turkey, Need help.
       
    12. Liam_Cairns

      Liam_Cairns Member

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Originally loud Music and was worsened by Micro-suction
      Hey Danton it is at the QE2 Hospital QLD Xray department. It is a private machine tho, so even with Medicare you get nothing back unless you have ever been an inpatient at QE2.

      Oh and I would personally not take anymore in your position.
       
      • Informative Informative x 1
    13. Arseny
      Wishful

      Arseny Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Possibly from problems with blood flow
      I had intramuscular injections.
      I had first course after a spike due to MRI, I think it helped a bit.
      Other two were combination of spikes due to noise exposure and allergies, mostly allergies. Thankfully I feel better now.
       
    14. racerfish
      No Mood

      racerfish Member Benefactor

      Tinnitus Since:
      2005
      Cause of Tinnitus:
      Noise / T worsened with antiobiotics
      What happened when you took the 64 mg dose?
       
    15. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      Apparently you can get it after subsequent acoustic traumas while you are still in the acute stage.
       
    16. Marko Nakovski
      Bored

      Marko Nakovski Member Benefactor

      Location:
      North Macedonia
      Tinnitus Since:
      27.04.2017
      Cause of Tinnitus:
      Loud music
      @Arseny Can you take those kinds of steroids only in the beginning stage of hyperacusis or isn't the timeframe of one's onset important? If so, the same applies for HBOT?
       
    17. Liam_Cairns

      Liam_Cairns Member

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Originally loud Music and was worsened by Micro-suction
      You got a source for this?
       
    18. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      An ENT told me.
       
    19. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      Also, that would make sense, new damage is acute in nature. Dexamethasone is proven to help in the acute stage.
       
    20. Liam_Cairns

      Liam_Cairns Member

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Originally loud Music and was worsened by Micro-suction
      Wait hold up sorry I misread your comment, when you say "you can get it" do you mean hyperacusis?
       
    21. Danton

      Danton Member

      Tinnitus Since:
      12/2018
      Cause of Tinnitus:
      Loud ear phones.
      I got pain in all through my legs, then a new one on my right hip, Unfournatly the hip pain continued after I stopped, now both my hips have pain in the sockets and I'm deathly afraid I got AVN (Necrosis) all I can do keep weight off the joints and see the doctor.
       
    22. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      do they not give it at ENTs?
       
    23. Liam_Cairns

      Liam_Cairns Member

      Tinnitus Since:
      2008
      Cause of Tinnitus:
      Originally loud Music and was worsened by Micro-suction
      Intratympanic injections of Dex but oral is normally Pred.
       
      • Agree Agree x 1
      • Informative Informative x 1
    24. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      Why isn't everyone in the acute stage of noise induced hearing loss being given Dexamethasone injections??????????
       
      • Good Question Good Question x 1
    25. Marko Nakovski
      Bored

      Marko Nakovski Member Benefactor

      Location:
      North Macedonia
      Tinnitus Since:
      27.04.2017
      Cause of Tinnitus:
      Loud music
      @JohnAdams What's the timeframe for acute stage? Is it 3 months or 6 months? I want to try it in order to improve my hyperacusis ...
       
    26. dpdx
      Disappointed

      dpdx Member Benefactor Hall of Fame

      Location:
      Murica
      Tinnitus Since:
      Onset:09/23/2017 Worsened: 1/17/2018
      Cause of Tinnitus:
      Acoustic Trauma, worsened by caloric test/VEMP test 90db nhL
      how many months have you had severe h?
       
    27. Marko Nakovski
      Bored

      Marko Nakovski Member Benefactor

      Location:
      North Macedonia
      Tinnitus Since:
      27.04.2017
      Cause of Tinnitus:
      Loud music
      @dpdx In general I have hyperacusis for 3 months and 1 week. My first 3 weeks were very severe, next 1 week little improvement, something like between severe and moderate, next 2 and a half weeks moderate then some setback (I don't know the cause, maybe car horns) and worsening, then after new year very severe for the past month, especially in the last 2 weeks. I would like to try these steroids.
       
    28. dpdx
      Disappointed

      dpdx Member Benefactor Hall of Fame

      Location:
      Murica
      Tinnitus Since:
      Onset:09/23/2017 Worsened: 1/17/2018
      Cause of Tinnitus:
      Acoustic Trauma, worsened by caloric test/VEMP test 90db nhL
      Do you have sound sensitivity or ear pain/burning?
       
    29. Arseny
      Wishful

      Arseny Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Possibly from problems with blood flow
      I think the time frame is very limited:
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664349/

      It would make sense to go for steroid treatment if you have recent injury. Otherwise it might be not worth it.

      I would attribute my progress more to HBOT than to steroids.

      You can try one or two injections and see if it makes any difference. At that point you can stop cold turkey.
       
    30. dpdx
      Disappointed

      dpdx Member Benefactor Hall of Fame

      Location:
      Murica
      Tinnitus Since:
      Onset:09/23/2017 Worsened: 1/17/2018
      Cause of Tinnitus:
      Acoustic Trauma, worsened by caloric test/VEMP test 90db nhL
      Is your tinnitus severe as well?
       

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