Recent content by gracepixie

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    Evaluating How a Tinnitus Implant Affects Tinnitus Loudness in Adults with Chronic Tinnitus and Varying Levels of Hearing Loss (TINIS)

    There might be a marketing issue for this device. Many of us with tinnitus and residual or normal hearing have been told we are not eligible for cochlear implants, so some people who could participate in the clinical trial might not even be considering it. No, this device does not go into the...
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    Elon Musk’s Neuralink Looking to Treat Tinnitus

    2028 is shaping up to be a good year for tinnitus. Cilcare results are expected, Neuralink may become available, Cochlear is expanding their tinnitus implant to a pivotal trial, and the SSD is finally being released. My crystal ball says to bet big on 2028!
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    Tinnitus Suppression with Electrical Stimulation at the Basal Contact of Cochlear Implant Electrodes: Significant Improvement in 8 of 10 Patients

    Cochlear is currently recruiting for a clinical trial of a device that aims to quiet tinnitus via electrical stimulation of the cochlea via the mastoid bone. You can find more info here. Another thing that makes me excited about this trial is that they have a very robust screening method to...
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    Neurosoft Bioelectronics: Implantable Electrodes to Treat Tinnitus

    Wow, @Jammer, I just want to say thank you for your service to the tinnitus community. Your experience with this clinical trial is an example to all of us of the importance of research and the risks involved. I’m deeply grateful that you took that chance for the sake of advancing scientific...
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    Cilcare's CIL001 Targets Cochlear Synaptopathy — An American/French Collaboration

    Just to emphasize this, I was in a seminar today where one of my colleagues presented unfavorable data for a new vaccine candidate he was testing. It was heartbreaking. The results in mice and non-human primates were spotless and very encouraging, yet the vaccine didn’t show even a measurable...
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    Neurosoft Bioelectronics: Implantable Electrodes to Treat Tinnitus

    @Jammer, you’ve probably shared your experience with DBS many times, but since it’s highly relevant to the discussion about Neurosoft, would you mind sharing it again here? Did you receive an implant? Was there any electrical stimulation involved in your procedure? And was your experience...
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    AudioCure AC102 to Treat Hearing loss and Tinnitus

    One big benefit of the Mongolian gerbil study is that it connects the improvement of tinnitus symptoms to synapse repair. Maybe AC102 will not be able to improve chronic tinnitus, but other therapeutics based on nerve repair, such as CIL-001 and NervGen, gain a boost of optimism that their...
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    Elon Musk’s Neuralink Looking to Treat Tinnitus

    This isn’t true. Several studies have demonstrated significant and consistent reductions in tinnitus with DBS, although the sample sizes have been very limited. Neurosoft is planning to launch their phase 2 study for their tinnitus implant next year, based on positive phase 1 data in a cohort of...
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    NervGen Pharma’s NVG-291-R Demonstrates Significant Functional Recovery in DoD-Sponsored Preclinical Models of Traumatic Hearing Loss

    lol, @Furetto and @Joeseph Stope, sorry for my tart responses. My PhD research is in vaccine design, so I’m very familiar with that field and loosely familiar with biotech in general. Joeseph, some people doubt that intratympanic (IT) injections will result in effective drugs for hearing loss...
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    Constant High-Pitched Reactive Tinnitus at 20 — Will It Improve and Are There Treatments?

    Sounds like you’re a great candidate for Cilcare’s upcoming clinical trial! Lucky you. They are recruiting people with tinnitus and no hearing loss, with preference given to reactive tinnitus. I believe the trial will start in a few months. Since you’re new, that might feel like a long time, but...
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    NervGen Pharma’s NVG-291-R Demonstrates Significant Functional Recovery in DoD-Sponsored Preclinical Models of Traumatic Hearing Loss

    No, the improvement was noticeable within 30 days. However, the article does not specify how much time passed between the blast injury and the first injection. Obviously, that implies the dose was given within 30 days, but it almost certainly began sooner. If I were to guess, I would say it was...
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    AdventHealth Research Institute Offers Phase II Clinical Trial of Etanercept for Treatment of Blast-Induced Tinnitus

    Phase 1 trials are only for first-in-human drugs, designed to test safety. Repurposed drugs that have already been FDA-approved for one condition can move directly to Phase 2 trials, which focus on efficacy for a different condition.
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    NervGen Pharma’s NVG-291-R Demonstrates Significant Functional Recovery in DoD-Sponsored Preclinical Models of Traumatic Hearing Loss

    From their website: It was given as subcutaneous daily injections, but the press release doesn’t mention when treatment was started or how long it lasted. Their ongoing clinical trial for Spinal Cord Injury includes two cohorts: A) injury occurring more than one year but no later than ten years...
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    AdventHealth Research Institute Offers Phase II Clinical Trial of Etanercept for Treatment of Blast-Induced Tinnitus

    I have three kids and a job. My tinnitus drives me nuts, but I also have responsibilities, as most of us do. If they have that much money, they should open additional trial sites. Providing equitable access is the responsibility of the drug developer, not the patient.