5-HTP for Tinnitus & Hyperacusis?

Hi all,

If you google - 5 HTP tinnitus - a lot of stuff, it's a natural food supplement, the precursor to Tryptophan.

Anyone tried this stuff?

Bit reluctant, want to but could have side effects.

5-HTP on Amazon.com

 

I started taking 5htp a few years ago to help me recover from some intense partying sessions. It definitely works to help improve and regulate mood. I've taken it since getting tinnitus and it helps with the stress. I haven't experienced any side effects but I only take 50mg for a few days at a time then take a break, side effects are common if you're doing high doses daily (300mg+), other than that it's pretty safe or at least has been in my experinece.

 

Just started 100mg an hour before bed, I also grind my teeth badly this is supposed to help you deal with that as well.

Anyway googling "5htp ringing ears" found this, http://ezinearticles.com/?All-You-Need-to-Know-About-5-HTP-and-Ringing-in-the-Ears&id=3912339

side effects not good according to them ,then as i get deeper into the site I see its just an affiliate Tinnitus Miracle book marketing site. These sellers are ;';'@@'';.,///// 's!!!!!!!!!!!

 

I was going to order some 5-htp to see if it could help change my mood and was just wondering if it worked or had any positive effects for any of you guys?

I need to get out of the slump I'm in but don't want to go down the route of prescription drugs.

 

It should work, it works on melatonin and seratonin.
Do not know about side effects, but u can google it. (or maybe not google, suppose it is generaly safe, just take it and if u feel something bad, see in side effects could it be from 5-htp). My opinion

 

I use it for sleep occasionally. It relaxes you and you fall asleep. It's similar to melatonin. I find both products give me very vivid dreams and I awake often.

 

5-HTP is a naturally occurring amino acid which our bodies make naturally and it is a precursor to both serotonin (mood regulator) & melatonin (induces sleep). I have read many reviews for 5-HTP supplements online and they are generally positive for it helping with sleep, mood regulation, anxiety and depression as @erik himself reports.

I'm naturally curious about any supplement or medication I try for my T. Here's what I found in my research of 5-HTP. 5-HTP activates the 5-HT2B receptors. According to Wikipedia, 5-HT2B receptors regulate serotonin release via the serotonin transporter, and are important both to normal physiological regulation of serotonin levels in blood plasma. This is all great for sleep and mood regulation but 5-HT2B receptors are know for cardiac hypertrophy (stiffening of heart muscle) which can lead to an increased chance of heart attacks. This is documented online, see links below:

http://www.ncbi.nlm.nih.gov/pubmed/12466135
http://www.ncbi.nlm.nih.gov/pubmed/15781732
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179857/
http://circres.ahajournals.org/content/104/1/1.full

I don't intend to put anyone off who is thinking of trying 5-HTP but thought I should highlight my findings and why I probably won't be taking it.

 

"Mood-Enhancing Formulation
A mood-enhancing formulation containing primarily 5-HTP, a form of vitamin B6, and St. John's wort, is designed to counteract age-related serotonin depletion and to provide general mood enhancement. Because it supports healthy serotonin levels, it may help those who are subject to mild or moderate depression. In addition, it may help with many other disorders.

5-HTP is well established for its mood-enhancing properties, among other benefits. St. John's wort, as well, has been studied with positive results for the treatment of mild depression. Its mechanisms of action are not clearly understood, but they are probably different than 5-HTP's. It has been used for a wide variety of conditions since at least the time of ancient Greece, and it was commonly used throughout the folk medicine of the Middle Ages. It is currently in widespread use in Germany as a standard treatment for depression.

Over the centuries, St. John's wort earned its reputation as a powerful mood-altering substance. Now science is confirming this reputation, and that is why Life Enhancement incorporates it in a nutritional supplement. When combined judiciously with 5-HTP, St. John's wort acts synergistically, i.e., the combined effect of the two ingredients is greater than the sum of their individual effects. Other uses for this formulation are for improved wound healing, anti-inflammatory effects, antimicrobial activity, sinusitis relief, seasonal affective disorder (SAD), and, especially, relief from depression"


http://www.chiro.org/nutrition/FULL/St_John's_Wort_Vs_Drugs.shtml

http://www.dailymail.co.uk/health/a...rozac-treating-depression-say-scientists.html

http://www.ncbi.nlm.nih.gov/pubmed/16160619

 

What sort of dosing did you use @erik? Same question to anyone else who used it and felt it had an effect.

Thanks for the info though, it seems to help some judging from the reactions here and the reviews on Amazon.

 

Hello Markku, didn't take it for very long, just a few days, why I don't know. Just didn't fancy this product for some reason.

 

love it - been taking it for 3 months and I think it works good .. I feel more as I used to before all this T depression came up ... now I`m back leveled out because of it I think .. it`s healthy and non toxic, non addictive (you can`t `feel` it) ... thumbs up

 

Just started taking 5-HTP, will report

The subject says it all!

I'm getting out of a major depression and am hoping to help the process along. Ordered a bottle of 50mg capsules. Took the first one about 30 minutes ago. Noticing no effect on the tinnitus (it's being a good boy today in general though), but (I think) a general mood improvement. This beat is banging!

Adverse effect: I definitely do notice the diminished appetite already. I was hungry before and couldn't wait to go to the supermarket, now I don't care.

I'm cautious because I did some research on drug forums, but doctors seem to mostly warn of using it to combat the adverse comedown effects from MDMA (mostly because users then tend to think they can roll more often as a consequence). I don't roll frequently anymore, so I guess that's not a danger. Will see how I sleep tonight. It's supposed to give you vivid dreams.

I'm also cautious of long-term effects (who knows, my body might end up producing even less serotonin and melatonin if I keep taking this stuff on the regular), so I guess this is a one-off experiment for now, a few days perhaps.

 

I'm curious, since you are coming out of a major depression are you on other antidepressants? I have wondered about 5-HTP but wasn't sure how it would interact with other meds that are messing with serotonin levels. Did your research turn up anything about that?

 

Yeah, you're supposed to be really careful (read: doctors don't recommend it), because you might end up with a serotonin syndrome. Serotonin is one of those things you CAN get too much of, so I wouldn't risk mixing 5-HTP and SSRIs. I got an SSRI prescribed but ended up not taking it, I was too wary of the side effects (plus Ambien, the other med my doc prescribed me, didn't agree with me at all, so I had all the less reason to trust the guy). So 5-HTP is merely my self-medication style alternative.

The doctor did say the same thing - that if I take the SSRI, I shouldn't take any other "mood boosters". Also, if this is helpful information, a friend used to take it for ecstasy comedowns and it worked for a while but then he said he crashed even harder. So bottom line is, I wouldn't mess with mixing.

 

So here's how I've been doing so far: after the initial elevation last night, I took another capsule today in the morning and didn't notice a great change in mood, except for the sleepiness. In fact right now I'm feeling fairly depressed but then again the last capsule was about 8 hours ago.

The sleep was weird, it felt like it was very light, in fact it felt like I couldn't fall asleep forever and remained in this weird state between waking and sleeping - until I finally looked at my mobile and it was 10 AM!

I haven't noticed a major change in my tinnitus. In fact my ears seem to be more sensitive today, like tinnitus acting up from me listening to music in my headphones. That said, in the past days my tinnitus once again changed in prominence and (I think) frequency, I guess as a result of the magnesium and 5-HTP intake, and upon waking today it was weaker than in the past days (my tinnitus had tended to be stronger upon waking up in the past couple of weeks) so results are inconclusive.

On the whole, I'm neither feeling particularly good nor I guess bad. Not sure if I should try to continue taking it. It definitely makes me a bit drowsy which I don't like, but then maybe I'll get used to it? I'll decide later.

 

Reporting back here. It's been a week now and there's definite improvement! I'm calmer, sleep better, am happier on the whole. I get stuff done at work again and am happy to go out! In spite of what you said, erik, my tinnitus seems a lot quieter/less intrusive most of the time. Sometimes it's all but gone. That said, once the effect wears off it does get louder again which is bothering. It all does confirm what I already suspected - that there's a direct connection between my tinnitus and my serotonin levels, which I messed with by means of prolonged substance and alcohol abuse.

Also, the crash in mood that happens if I don't regularly take it is bothering, too. I had taken a capsule at around 7 PM last night and then woke up at 10 AM today, feeling totally depressed. Now, some hours after the new capsule, I'm calm and feeling normal again. One other side effect I've noticed is a very slight weakness in the joints. I get a similar weakness from E, but much much stronger.

The dizziness has decreased, but still unsure for long much longer I should continue the experiment. Classic antidepressants are usually taken over a prolonged amount of time, but a friend doctor told me it was safe to stop the 5-HTP at any time. I don't want to make my body produce even less serotonin, but then again it seems like it already produces way too little, which perhaps justifies continued 5-HTP intake.

 

I am about to start on this, since I decided to stop all use of Mirtazapine and Trazodone, both of which were not working all that well for sleep and were affecting my tinnitus. I was hoping it would have an immediate impact but I guess I will have to be patient. I will try to post my experience with it, but I am hopeful based on what I've read here.

 

I hope it works as well as H has been bad of late. Last night it made no difference and I had trouble falling asleep, but from what I read here, I need to be patient.

 

@erik - What should I be looking for when 5HTP begins to have an impact in a week, two weeks? I know I must seem over eager, but I am in the midst of a horrible transition away from antidepressants and it's like I'm learning to sleep again. What was your experience when the 5HTP began to work for you?

 

I can happily report that, after close to two weeks, this supplement is starting to work for me. I have found that it does relax me and helps me get close to sleep. I was able to reduce my dosage of Trazodone to 12.5 mg last night for the first time. I can't say whether 5HTP has had any other impact, like for hyperacusis or tinnitus, but given that this is just beginning to have a positive impact on my anxiety, maybe more positive benefits are to come. But even if all I get is a natural night's sleep free of Trazodone, I'll be happy.