A Likely New Contributor to Age-Related Hearing Loss Found

Discussion in 'Research News' started by exodus, Jul 13, 2015.

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    1. exodus
      Cold

      exodus Member

      Tinnitus Since:
      05/2008
      Something interesting

      http://medicalxpress.com/news/2015-07-contributor-age-related-loss.html

      A likely new contributor to age-related hearing loss found
      foundalikely.jpg
      Mature hair cells, left, lose connections to outgoing neurons (blue) and gain connections to incoming neurons (red) as they age, right. Credit: Paul Fuchs, Johns Hopkins Medicine

      Conventional wisdom has long blamed age-related hearing loss almost entirely on the death of sensory hair cells in the inner ear, but research from neuroscientists at Johns Hopkins has provided new information about the workings of nerve cells that suggests otherwise.


      In a paper published July 1 in The Journal of Neuroscience, the Johns Hopkins team says its studies in mice have verified an increased number of connections between certain sensory cells and nerve cells in the inner ear of aging mice. Because these connections normally tamp down hearing when an animal is exposed to loud sound, the scientists think these new connections could also be contributing to age-related hearing loss in the mice, and possibly in humans.

      "The nerve cells that connect to the sensory cells of the inner ear are known to inhibit hearing, and although it's not yet clear whether that's their function in older mice, it's quite likely," says Paul Fuchs, Ph.D., the John E. Bordley Professor of Otolaryngology-Head and Neck Surgery at the Johns Hopkins University School of Medicine. "If confirmed, our findings give us new ideas for how physicians may someday treat or prevent age-related hearing loss."

      Fuchs says the new research builds on the knowledge that inside the ear lies a coiled row of sensory cells responsible for converting sound waves into electrical signals sent through nerve cells to the brain, which processes and tells animals what they "hear." Two sets of these so-called hair cells—named for the filaments that act like antennae picking up sound waves—exist, an inner tier closest to the brain and an outer tier. The outer ones have a secondary function: to amplify the sound waves within the inner ear. Not surprisingly, Fuchs notes, a loss of outer hair cells closely correlates with a loss of hearing.

      But studies over the last decade have suggested that changes over time also occur in the connections between hair cells and the nerve cells to which they are attached.

      Each of those nerve cells is like a one-way street, Fuchs says, taking signals either from the ear to the brain or vice versa. The nerve cells that take signals to the ear are known to turn down the amplification provided by outer hair cells when an animal is, for example, exposed to a noisy environment for an extended period of time.

      Previous research has suggested that with age, inner hair cells in mice and humans experience a decrease in outgoing nerve cell connections, while incoming nerve cell connections increase.

      To find out if the new connections worked—or worked normally—Stephen Zachary, a graduate student in Fuchs' laboratory, painstakingly recorded electrical signals from within the inner hair cells of young and old mice.

      He found that the incoming nerve cells were indeed active and that their activity levels correlated with the animals' hearing abilities: The harder of hearing an animal was, the higher the activity of its incoming nerve cells.

      "These nerve cell connections seem to be reverting back to the way they worked during early development before the animals' sense of hearing was operating," says Fuchs. "We don't know why the new connections form, but it might be as simple as a lack of competition for space once the outgoing nerve cells have retracted."

      If the same phenomenon is occurring in human ears, Fuchs and his team say there may be ways of preventing the incoming nerve cells from forming new connections with inner hair cells, a technique that could help maintain normal hearing through old age.
       
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    2. exodus
      Cold

      exodus Member

      Tinnitus Since:
      05/2008
      if i understand well
      this new connection is forming a kind of short circuit wich is decreasing the ability of the hair cells to hear correctly?

      correct me if i m wrong

      thanks
       
    3. Nucleo

      Nucleo Member Benefactor

      Tinnitus Since:
      02/2011
      From what I could understand, it means that when we age, hair cells lose their efferent connections to the brain and are replaced by afferent connections which do not make us perceive sound. The hair cells might still be standing but the electrical signals they generate are not being relayed to the brain, making us effectively deaf in the faulty connected regions.

      Quite a fascinating find really.
       
    4. Mic
      Buzzed

      Mic Member

      Tinnitus Since:
      04/2014
      Cause of Tinnitus:
      Otitis media / Ear infection
      Interesting theory. This again gives some supporting clues about my own theory that T is a product of false amplification of background noise from the inner ear... You can compare it with the sound you hear when turning the volume of your stereo up when there is no song playing.
       

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