Cilcare's CIL001 Targets Cochlear Synaptopathy — An American/French Collaboration

[Fra]

It seems like the issue with the viral vector has now been resolved.

Is there any published paper that details the resolution of the viral vector issue?

 

[Josh-mh]

I am very interested in how Cilcare will be testing for cochlear synaptopathy outside of speech-in-noise tests and ABRs. I believe they are working on a way to test for this alongside their regenerative therapies.

 

[LovableGamer]

Hey, I just wanted to ask if there have been any updates on when the trials are starting. I believe it should be soon. I really hope I can join because of my hearing loss and tinnitus. I am hoping they will begin those groups early next year. If anyone has any information, please let me know. Thank you!

 

[ploughna]

On the topic of drug delivery through the round window discussed earlier in this thread, this is pretty interesting:

Cilcare launches a groundbreaking 3D Bioprinting Project with human cells to advance therapies for hearing disorders - Cilcare

€40 million series A completed to accelerate development of innovative treatments for early hearing loss

www.cilcare.com

 

[LovableGamer]

On the topic of drug delivery through the round window discussed earlier in this thread, this is pretty interesting:

Cilcare launches a groundbreaking 3D Bioprinting Project with human cells to advance therapies for hearing disorders - Cilcare

€40 million series A completed to accelerate development of innovative treatments for early hearing loss

www.cilcare.com

Awesome find! I really hope this leads to faster and smoother progress in research and treatment.

 

[JJL]

I have been in contact with the researcher; however, I'm a little reluctant. Intratympanic injections are no longer seen as the best route to the cochlea. All trials using this method have failed, with companies often blaming the lack of permeability.

Many institutions are now moving away from this approach and have discovered new proprietary routes.

Hi @Nick47, what are the new proprietary routes to get access to the cochlea?

 

[ploughna]

An interesting watch:

 

[Joeseph Stope]

An interesting watch:

Really good video, but many of us cannot listen to the sound due to Hyperacusis.

I wonder if there is a transcript that covers the basics. The subtitles are too small and move too quickly. Maybe I should get a magnifying glass.

It is great to hear that something else is on the way. If Auricle does not work for me, Cilcare might.

 

[Emao]

Transcript of the video is available here:

https://youtubetotranscript.com/transcript?v=S7W_3aDUmCk&current_language_code=en

 

[Joeseph Stope]

Transcript of the video is available here:

https://youtubetotranscript.com/transcript?v=S7W_3aDUmCk&current_language_code=en

This looks very promising.

 

[Fields]

Off-topic, but it doesn't really warrant its own thread, I think:

Japanese scientists have found a way to naturally grow new teeth

Medical innovations like these provide me with some hope that eventually we'll also crack the code for hearing-related issues—possibly via CILCARE.

 

[Kemper]

Researchers keep a mammalian cochlea alive outside the body for the first time

This technological breakthrough may improve our understanding of the cellular mechanisms behind hearing and its loss, which remain poorly understood.

www.eurekalert.org

 

[Joeseph Stope]

Researchers keep a mammalian cochlea alive outside the body for the first time

This technological breakthrough may improve our understanding of the cellular mechanisms behind hearing and its loss, which remain poorly understood.

www.eurekalert.org

This looks like a goldmine.

For those of us who are not very scientific, the overall picture is beginning to emerge. Very often the source of our tinnitus and hearing loss lies in the cochlea, but it can also reside in the brain, or in both the cochlea and brain together.

In the search for a pharmaceutical or genetic remedy, one major problem is delivering the treatment to the correct location, the actual site of the injury. The difficulty lies in the fact that the cochlea is the hardest bone in the body, and its location close to the brain makes it hard to access and observe.

If what I read in Kemper's link above is true, then delivering the medication and observing its effect over time should be straightforward.

This would allow researchers to adjust and refine the therapies while monitoring the effects in real time.

If you want to be cured, it might even help if you were a bullfrog.

In one of my long posts from a while back, I shared my struggle with taking care of a plant. I gave it plenty of sunlight and water, but it did not thrive. It turned out to be a desert plant that lives in a cave. Too much sunlight and too much water were not what it needed.