Complete Restoration of Hearing Loss and Cochlear Synaptopathy

Complete Restoration of Hearing Loss and Cochlear Synaptopathy via Minimally Invasive, Single-Dose, and Controllable Middle Ear Delivery of Brain-Derived Neurotrophic Factor–Poly(dl-lactic acid-co-glycolic acid)-Loaded Hydrogel

Sounds really promising, doesn't it?

 

This is exactly what OTO-413 was I believe, are there any differences?

 

Unfortunally this will not cure tinnitus.

 

This seems like a similar approach now that you mention it. Maybe the delivery mechanism is different? I thought it was news

 

Would be great if this worked in human trials.

 

Some questions:

1) It's mice, will it translate to humans? Guinea pigs have hearing physiology close to humans, mice less so.

2) This is a BIG ONE for me: how long after noise exposure were the mice treated? If it's within days or weeks, I ain't enthused. Acute vs. chronic is always a big difference.

It ain't that promising to be honest.

 

Like everything else, hopefully this leads to human trials and eventually a measurable objective treatment for hearing loss.

 

Mice again

 

I can't get excited about studies with mice. When they actually inject humans and get the same results, let me know.

 

Anyone that reads any study on hearing loss or tinnitus MUST ask at least these 2 questions.

1. Were they human subjects?
2. Was the tinnitus or hearing loss chronic?

The study MUST be able to answer yes to both for further interest to be maintained, at least as a patient.

I'm even skeptical of Prof. Thanos Tzounopoulos' work as his studies cannot answer yes to any of the above questions.

 

If you have the time, research how antiepileptics benefit epilepsy patients and visual snow syndrome/HPPD sufferers to have an understanding of how these drugs work.

I expect Prof. Tzounopoulos' stuff to be, at best, a good band-aid-like treatment to the actual problem for most, and a permanent reduction for a small group, maybe elimination for even a much smaller group, based on especially what happened with Retigabine use here on Tinnitus Talk.

Similar results are observed with antiepileptic use with visual snow syndrome/HPPD/epilepsy as well.

 

It’s a big and exciting year for mice with tinnitus.

 

I feel bad for the mice. Feel free to test on me