Dimethyl Sulfoxide Therapy in Subjective Tinnitus of Unknown Origin

Discussion in 'Research News' started by Lupo, Mar 15, 2015.

tinnitus forum
    1. Lupo

      Lupo Member

      Location:
      Los Angeles
      Tinnitus Since:
      2/2015
      Cause of Tinnitus:
      Unknown
      Has anybody read this study on DMSO:

      http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1975.tb25389.x/abstract

      Does anyone have a PDF?

      From another source, I think this is the study's abstract:

      "In fifteen patients affected by essential nonvibratory tinnitus, local applications in the external auditive canal of 2 ml medicated DMSO spray were made. The spray solution contained DMSO integrated with anti-inflammatory and vasodilatory substances. This application was repeated every four days for a month. At the same time each patient was administered a daily intramuscular injection of a preparation that contained DMSO and a vasodilatory component. The therapeutic effect was evaluated through the subjective modification of the symptom and functional tests of the auditory system. Of the fifteen patients treated, the tinnitus symptom completely disappeared in nine, and did not return during a one-year observation period. The patient's symptoms diminished in two cases, and in four cases the permanent tinnitus became occasional, triggered principally by environmental cold. It is important to note that among the concomitant signs, the five patients with vertigo noted improvement. Hypacusis diminished in three of the six patients affected. Insomnia disappeared in eight and diminished in seven cases. The rise in the average tympanic membrane temperature from 36.8 degrees C before to 37.9 degrees C after treatment was noteworthy. This could indicate an improvement of the blood flow in the inner ear."

      This looks hopeful but it's a very old study... any follow-up? I can't find any.
       
    2. James White
      Anime

      James White Member Benefactor

      Location:
      Toulouse, France
      Tinnitus Since:
      April 2013
      Cause of Tinnitus:
      Maybe loud music. Not sure.
      Hi, what is "essential nonvibratory tinnitus" ?
       
    3. Lupo

      Lupo Member

      Location:
      Los Angeles
      Tinnitus Since:
      2/2015
      Cause of Tinnitus:
      Unknown
      Judging from the paper, it means subjective rather than objective tinnitus.
       
    4. Lupo

      Lupo Member

      Location:
      Los Angeles
      Tinnitus Since:
      2/2015
      Cause of Tinnitus:
      Unknown
      This is a really interesting read. Why hasn't this been followed up on? Seems most directly relevant to non-noise-induced tinnitus. All patients had tinnitus for 6+ months before the study. 9 of 15 had complete relief, 4 more partial. Any thoughts on the drugs delivered with the DMSO vehicle?
       
    5. steinamo
      Balanced

      steinamo Member

      Tinnitus Since:
      July 2015
      Anyone know anything about this stuff? There's a couple bottles sitting on the free shelf at my work right now.
       
    6. DebInAustralia

      DebInAustralia Member Benefactor Team Research

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      Dmso is an industrial solvent right??
       
    7. steinamo
      Balanced

      steinamo Member

      Tinnitus Since:
      July 2015
      It is indeed, but apparently it's also a homeopathic remedy for pain. Everything I'm seeing online is very hippy-dippy, and knowing my line of work it's most likely snake oil.
       
    8. Poyraz

      Poyraz Member

      Tinnitus Since:
      February 2016
      Cause of Tinnitus:
      Benzos, Stress, Anxiety, Loud Music, Jaw Problems. Who knows
      Sounds interesting but I don't know why no one talks about it. Is there any one in the forum already tried this treatment?
       
    9. linearb
      Psychedelic

      linearb Member Hall of Fame

      Location:
      East Coast USA
      Tinnitus Since:
      1998
      so, DMSO on its own probably won't do much. DMSO crosses the skin barrier and carries other molecules with it.

      I'm looking at the full text of the article. The concoction they actually used was:
      Phenylbutazone (NSAID), moroxydine (antiviral with action against HSV), hydrocortisone (steroid), lidocaine, propyl carbinol (an alcohol, I'm unclear on its use here), and DMSO. The injections they received contained GABA, chlorhydrate, GHB, l-actylglutamine, and lidocaine.

      There's a whole lot of active substances going on there. It would be interesting to see this replicated. If one were so inclined, making a solution of an anti-inflammatory in DMSO should be possible. However, I think it's pretty interesting that an antiviral was included, given speculation about the role of the herpes virus in inner ear pathologies.
       

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