DiPT an Auditory Psychedelic

DiPT or Diisopropyltryptamine is a psychedelic tryptamine that primarily affect the auditory perception. It is well known that psychedelics cause long term changes in the brain by altering gene expression and downregulation of 5-HT2A and 5-HT2C receptors.

I am curious if this "auditory psychedelic" somehow has the potential to change tinnitus perception in the long term.

 

I wouldn't advise taking psychedelic drugs to "fix" the issue.

 

Haha, I think it's absolutely possible that novel tryptamines could have a long-lasting or permanent effect on tinnitus, but I wouldn't want to place a bet about which way it would go.

It's worth noting that Alexander Shulgin, who invented the vast majority of synthetic psychedellic tryptamines and phenethylamines, had tinnitus, and often found it was impacted by these drugs.
https://www.erowid.org/library/books_online/tihkal/tihkal43.shtml
https://www.erowid.org/library/books_online/tihkal/tihkal36.shtml
https://www.erowid.org/library/books_online/tihkal/tihkal13.shtml

I know of one anecdote from the internet of a guy who swears that taking a monstrous dose of psilocyban mushrooms cured his tinnitus... and also caused him to permanently lose his sense of smell. I have read many, many more accounts of people developing tinnitus as a result of such experimentation.

 

Seroquel isnt one of these drugs are they?

 

These drugs are all (mostly illegal) hallucinogens. Different receptor profile, different mechanism of action.

That said, I don't think the long term risk profile of Seroquel is particularly less frightening than any of these drugs. Hallucinogens have a lot of short term risks, provoking extremely intense, difficult-to-integrate experiences. Antipsychotics like Seroquel are dangerous for a different set of reasons, but I personally wouldn't exactly call them "safer"; apples and oranges.

 

Seroquel is kind off the opposite of a psychedelic. It binds to the same receptors (5-HT2A, 5-HT2C, D2) but not as an agonist but as an antagonist/inverse agonist (Seroquel blocks the effects of psychedelics).

5-HT2A and D2 antagonism may cause a reduction in tinnitus perception in some people. But this effect is only temporary.