Frequency Therapeutics — Hearing Loss Regeneration

Discussion in 'Research News' started by RB2014, Dec 8, 2016.

    1. Stefaniie

      Stefaniie Member

      Tinnitus Since:
      2017
      Cause of Tinnitus:
      noise exposure
      Y'all still think it's possible for this drug to hit the market within 5 years?
       
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    2. derpytia
      Pooptoast

      derpytia Member Benefactor

      Location:
      Rescue, California
      Tinnitus Since:
      04/2014 (many increases since then)
      Cause of Tinnitus:
      Progressive hearing loss / noise / ETD
      Gotta Area 51 it. They can't stop all of us ;) :LOL:
       
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    3. bell

      bell Member Benefactor

      Tinnitus Since:
      2004
      You can walk there and tell them to please give their news soon on behalf of all of us.
       
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    4. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Certainly.
       
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    5. Earing
      No Mood

      Earing Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      noise
      All they would need is a 90dB siren and you and your army would be running for the earplug station.
       
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    6. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      It's called LRAD.
      *SOUND WARNING IN THE VIDEO TURN DOWN YOUR VOLUME*
      Long Range Acoustic Device (LRAD) G20 Pittsburgh


      Whoever approved this for use against civilians deserves (_______)-fill in the blank.
       
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    7. d'Wooluf

      d'Wooluf Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      unknown
      "Thousands deafened by hearing restoration startup"
       
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    8. Earing
      No Mood

      Earing Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      noise
      Price of treatment just doubled.
       
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    9. AVIYT
      Wishful

      AVIYT Member Benefactor

      Tinnitus Since:
      January 2019
      Cause of Tinnitus:
      Pregabalin
      Sorry, but those weren't just peaceful protestors. Those were rioters who destroyed stuff at the G20 Summit and some were running amok.

      I believe it was used fairly. There is a difference between someone getting tinnitus innocently from listening to music or chemotherapy, and someone who is a criminal who had their ears damaged in the process.
       
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    10. FGG
      No Mood

      FGG Member Hall of Fame

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Multi-factorial
      Holy shit dude. Talk about the punishment not fitting the crime. Essentially a "life sentence" of a psychoogically tormenting affliction for rioting?
       
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    11. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      I agree, they all deserve to die. I for one welcome my globalist masters making big decisions about world governance behind closed doors. How dare these scumbags even question it.
       
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    12. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      I'm again starting to wonder if the root of most of our cases is simply a loss of input from destroyed haircells and FX-322 will heal us almost totally. Why wouldn't this be the case? I am seriously asking for someone to shoot that notion down.
       
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    13. Earing
      No Mood

      Earing Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      noise
      There is nerve damage elsewhere in the system that FX-322 won't fix.
       
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    14. JohnK
      Busy

      JohnK Member

      Location:
      SF Bay Area
      Tinnitus Since:
      10/26/2015 (habituated) 5/13/2019
      Cause of Tinnitus:
      Doxycycline (2015) Otimize ear drops [neomycin] (2019)
      Here are some random spitball ideas:
      • FX-322 heals some, but not all (or enough) hair cells to dampen tinnitus
      • It could be unequal in results for different causes of hair loss (noise vs ototoxicity vs infection vs age vs idiopathic)
      • We don't have any proof restoring hearing would undo the physical changes in the brain that are the manifestation of tinnitus
       
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    15. all to gain
      No Mood

      all to gain Member Podcast Patron Benefactor Hall of Fame

      Tinnitus Since:
      -
      Cause of Tinnitus:
      -
      What about if there were innocent people in the area or journalists? What about young kids who may have strayed into the line of fire as it were?
       
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    16. Earing
      No Mood

      Earing Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      noise
      What about the unborn baby that was damaged in the womb?
       
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    17. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      What about in people that have tinnitus reduction/elimination from hearing aids?
       
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    18. Coleoptere
      Alone

      Coleoptere Member

      Location:
      The Hague
      Tinnitus Since:
      2002
      Cause of Tinnitus:
      Bell's Palsy, hearing loss
      I may be optimistic but I think GenVec/Novartic (CGF166), Frequency and Audion work on the assumption that that is the case. And they are in a far better position to judge it than us, with a lot of data from their tests etc.

      So my Q would be: what data do we have to support that it is not the case? :)

      Hope that makes sense.
       
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    19. spingee
      Wtf

      spingee Member

      To all of you-

      Do you really believe that your loud tinnitus is caused by max 10 dB hearing loss on 8 kHz+?
      Do you really believe that it causes your brain to change?

      Then I have bad news for you. FX -322 and any other drug based on growing new hair cells won't help you.
       
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    20. Sironketchup

      Sironketchup Member

      Tinnitus Since:
      11/2018
      Cause of Tinnitus:
      SSHL / Stress / Covid?
      It's not the hearing loss, it's the nerve damage.
       
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    21. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Right, but we know that when hair cells are regenerated that the nerves regrow and reconnect. It seems like the only part of the system that doesn't heal on its own is the hair cell. I am hoping that the regeneration of the hair cells will cause a downstream healing of all of the other systems.
       
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    22. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Maybe not...
       
    23. Daniel Lion
      Ape-like

      Daniel Lion Member Podcast Patron Benefactor Hall of Fame

      Location:
      SE Asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      Shiiiittttttttt pooopy pop drops, this thread, much like this forum, has its ebbs and tides and different flows. Laypeople, undoubtedly very smart, have all earned their PhDs in hyper speculation mixed with a healthy dose of cynicism, myself included, but I remain an optimist.

      Speaking for myself and a few others with freaking bad hearing loss, enough to warrant CI and running after that, hearing aids, I am freaking hopeful this drug will help us. “Cautiously optimistic“ , was the phrasing a fellow sufferer used. Don’t want to jump off a bridge if the goop doesn’t work.

      For those with hearing loss, noise induced in many cases, it’s a decent hopeful gamble to speculate it may reduce a persons tinnitus much as hearing aids do for “some people”.

      “It’s not hearing loss, it’s nerve damage”, a member said, thanks Einstein.

      We may be witnessing a medical breakthrough and medical marvel brought to us by some of the best minds in the game.

      I try and dampen my optimism, so I won’t be heartbroken, but it’s really a struggle for me and need to calm my shit down.

      I remain hopeful that this drug will help restore hearing, and will as an added bonus help reduce some folks' tinnitus.

      We have nothing at this moment in history, except personal coping strategies to deal with our afflictions. This could be a great break for us, and if it worked for a person who doesn’t qualify for neuromodulation because of hearing loss, could then hypothetically be able to benefit from bimodal neuromoduation.

      Whoever said there will be one fix for tinnitus?
      Is it not possible a combination of therapies at this juncture in history may work?

      Love you FX, I remain a loyal groupie despite my best efforts.
       
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    24. Earing
      No Mood

      Earing Member

      Tinnitus Since:
      2010
      Cause of Tinnitus:
      noise
      You asked for reasons.
       
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    25. Auron
      Pacman

      Auron Member

      Location:
      Planet Earth
      Tinnitus Since:
      Spring
      Cause of Tinnitus:
      Acoustic Shock
      I put all my eggs in one basket. I'm all in on FX-322. It helps me get out of bed in the morning. I thought about that exact scenario, damage elsewhere which can't be repaired anytime soon... My only hope is that my mild tinnitus (audible in quiet rooms) is caused by my minor hearing loss (about 5 dB across almost the board up to 8 kHz). Or at least, I hope, that hearing restoration will fix this ringing caused by fans, and fridges etc...

      This thought crossed my mind. I recall watching a video in which scientists helped the body heal Target A and they were shocked that the body then healed Target B and C.

      **I will search for the video, but this was many years ago, if someone knows of a similar study, please do tell**
       
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    26. F-u-T

      F-u-T Member Podcast Patron Benefactor

      Location:
      AZ USA
      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Acoustic Trama
      F@*k yes I do. My tinnitus started IMMEDIATELY after an acoustic trauma event and has been raging for the last 10 months.
       
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    27. JohnK
      Busy

      JohnK Member

      Location:
      SF Bay Area
      Tinnitus Since:
      10/26/2015 (habituated) 5/13/2019
      Cause of Tinnitus:
      Doxycycline (2015) Otimize ear drops [neomycin] (2019)
      What about people who didn't?
       
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    28. JohnAdams
      Festive

      JohnAdams Member Benefactor Hall of Fame

      Location:
      Vatican
      Tinnitus Since:
      May 1st 2018
      Cause of Tinnitus:
      Aspirin Toxicity/Possibly Noise
      Right exactly, they are perhaps part of a different subtype with a different etiology.
       
    29. Rb86

      Rb86 Member

      Tinnitus Since:
      5/31/19
      Cause of Tinnitus:
      Noise
      That's the one beauty of medicine, especially on this scale... it either works or doesn't. That's a lotttttt of money they're betting with. I have confidence thus far.
       
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    30. AUTHOR
      AUTHOR
      RB2014
      Confused

      RB2014 Member Benefactor

      Location:
      US
      Tinnitus Since:
      12/2014 became noticable
      Cause of Tinnitus:
      Loss of hearing and then stress and anxiety
      Yep that's all it takes. 10 dB at 8 kHz can get it started. The anxiety associated with the tinnitus for the first time can get it to ramp up super loud. Then loss of sleep, then more anxiety, then more tinnitus... Raging tinnitus on a 10 dB hearing loss... Maybe add a little caffeine or nicotine to ramp it up a little more...

      Then after months and months, If you can control the anxiety and do all the things we tell you to get better, you can get it down to a light whisper if you're lucky but at that point it's probably never going away unless you can get your 10 dB back.
       
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