Frequency Therapeutics — Hearing Loss Regeneration

Discussion in 'Research News' started by RB2014, Dec 8, 2016.

    1. RingingBrother

      RingingBrother Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Noise induced hearing loss
      Do you think FX-345 will get more outer hair cells than FX-322?
       
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    2. Nick47

      Nick47 Member

      Tinnitus Since:
      2015
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      Viral/noise
      From what I understood of the animal models, it was inner hair cells.

      We all know this is going to fail, why do we get our hopes up every time?
       
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    3. ThomasF
      Creative

      ThomasF Member

      Location:
      Florida
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      2001
      Cause of Tinnitus:
      Probably loud music
      I wouldn't sink them just yet. They've made corrections to their tests so the possibility still exists for success.
       
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    4. SmallRonnie
      Ape-like

      SmallRonnie Member Podcast Patron Benefactor

      Location:
      Ireland
      Tinnitus Since:
      2021
      Cause of Tinnitus:
      Factory noise + Headphones + Clubbing + Vaccine? + Stress
      Brother, if you have a more positive outlook on the future, then you will have a better future.
       
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    5. RingingBrother

      RingingBrother Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Noise induced hearing loss
      Both FX-322 and FX-345?
       
    6. RingingBrother

      RingingBrother Member

      Tinnitus Since:
      2018
      Cause of Tinnitus:
      Noise induced hearing loss
      I think they haven't released anything for FX-345 yet. I'm not sure.
       
    7. Nick47

      Nick47 Member

      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      @RingingBrother, again it's only my understanding and correct me if I'm wrong, but both target inner hair cells. The difference between them is FX-345 penetrates deeper into the cochlear, in theory targeting lower frequencies.
       
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    8. Chad Lawton

      Chad Lawton Member

      Tinnitus Since:
      2/19/18
      Cause of Tinnitus:
      Possible Ototoxicity + Noise Exposure
      Carl LeBel said on the HLAA Q&A earlier this year that their compounds activate both inner and outer hair cells. I speculate that it has more to do with the cochlear anatomy than the compound only targeting 1 type of hair cell. If you look at their treated mouse cochlea image which is currently slide 48 on their investor deck you can see there was robust inner hair cell response at the highest frequencies but little outer hair cell growth but as you get deeper into the cochlea, you can see more outer hair cells responded.
       
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    9. CRGC

      CRGC Member

      Location:
      Montreal
      Tinnitus Since:
      06/2022
      Cause of Tinnitus:
      SNRI/Noise
      Frequency Therapeutics to Participate in September Investor and Medical Conferences
      • American Academy of Otolaryngology – Head and Neck Surgery (AAO-HNSF) 2022 Annual Meeting and OTO Experience: “Presentation on results of four single-dose trials of FX-322, showing improved speech perception” by Kevin Franck, Ph.D., SVP Marketing and New Product Planning, Tuesday, September 13, 2022, 5 p.m. EST
      Source: BusinessWire

      Wondering if there will be any new information on FX-322, or just a rehash of their past positive results.
       
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    10. Street Novelist
      Depressed

      Street Novelist Member

      Location:
      Bay Area
      Tinnitus Since:
      February 2018
      Cause of Tinnitus:
      Listening to loud music through headphones
      I wish they would tell us when the FX-345 trial will begin.
       
    11. Keith Handy
      Ape-like

      Keith Handy Member

      Location:
      Rochester, NY, USA
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      11/2020
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      Stress + sleep deprivation + noise
      99% sure there will be no new info. It doesn't happen at these events. When they have something to announce, they make their own announcements. They should be doing safety trials for the newer FX-345 soon, though, so keep an eye out for that.
       
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    12. Padraigh Griffin

      Padraigh Griffin Member Podcast Patron Benefactor

      Tinnitus Since:
      05/2020
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      Unknown/Stress
      Had it not started yet? Ah well. That is the game changer. I really don’t know why they keep flogging a dead horse with FX-322 but hey that’s just my opinion. Getting down to c. 4,000 Hz is what we need.
       
    13. Nobody19

      Nobody19 Member Benefactor

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      Clubbing
      Why don't you look on their website?
       
    14. vttbx

      vttbx Member Benefactor

      Location:
      Los Angeles
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      01/2001
      Cause of Tinnitus:
      Noise Induced
      Is there anything preventing FX-345 from affecting frequencies up to 20 kHz? Or are the higher frequencies more difficult to treat?
       
    15. Gb3

      Gb3 Member

      Tinnitus Since:
      12/19
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      Sshl
      Do you think you are a dog?
       
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    16. Cernuto
      Spaced

      Cernuto Member

      Tinnitus Since:
      2010
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      My understanding is the highest frequencies are treated first due to the nature of the way the drug travels through the cochlea.
       
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    17. Nick47

      Nick47 Member

      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      The lower frequencies are harder to reach as they are further in the cochlear. It sounds like a change to the delivery agents rather than the FX-322 formula will be used for FX-345. Either way be realistic, I'm not impressed with Frequency Therapeutics so far as a company.
       
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    18. John Joseph

      John Joseph Member

      Tinnitus Since:
      05/2022
      Cause of Tinnitus:
      Acoustic Trauma
      In theory, yes. In pure terms of physical proximity, that's the case. But there might be some other factor at play.

      The crux of this question is very interesting to me and I hope they're trying to figure out why the outer hair cell improvement is lagging behind the inner, especially in the upper register.
       
    19. SmallRonnie
      Ape-like

      SmallRonnie Member Podcast Patron Benefactor

      Location:
      Ireland
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      Cause of Tinnitus:
      Factory noise + Headphones + Clubbing + Vaccine? + Stress
      I believe most people with tinnitus have high frequency hearing loss too. Makes sense if it's the easiest to damage then it should be the easiest to heal too.
       
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    20. EkkoMusic

      EkkoMusic Member

      Tinnitus Since:
      01/2021
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      Unknown
      Can you explain? From what I understand:

      1. Certain hair cells are not intrinsically stronger than other hair cells.
      2. In cases of SSNHL recovery with steroids, antivirals, etc., high frequency hearing function is less likely to be restored than lower frequency hearing function.

      Please correct me if we have data that says otherwise!
       
    21. SmallRonnie
      Ape-like

      SmallRonnie Member Podcast Patron Benefactor

      Location:
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      I'm just going off the anatomy of the cochlea. The higher frequency parts are on the outside and get hit first so I would assume that's why they usually get damaged more. Like how when you're bowling and the front pins are always more likely to get knocked down. Not very scientific but seems logical and most people with tinnitus do just have higher frequency hearing loss. I'm not a doctor lol.

      I'm not sure about how those steroids work but FX-322 does work better for higher frequency hearing loss and FX-345 is then better for more lower frequencies too. I just assumed it's because the drug needs to physically hit those areas and they are the closest to the delivery point.

      Maybe the steroids are more systemic? The steroids are always given IT? I don't know how they work at all.
       
    22. vttbx

      vttbx Member Benefactor

      Location:
      Los Angeles
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      Cause of Tinnitus:
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      Only in years.
       
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    23. John Joseph

      John Joseph Member

      Tinnitus Since:
      05/2022
      Cause of Tinnitus:
      Acoustic Trauma
      Well, FX-322 only really touches the higher frequencies, so yes, that's where it works best, because that's the only place it could work.

      The only audiogram improvements in any of the trials were seen in a few patients at 8 kHz. I don't believe any of the extended high frequency audio testing showed any notable improvements. So, this, along with the image of the mouse cochlea basically showing the same results (outer hair cell regrowth improving the further down the cochlea you go), seems to suggest there is something getting in the way of robust regeneration at the very high frequencies.

      I'm sure they're interested in why and I hope they crack it.
       
    24. Nick47

      Nick47 Member

      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      They had audiogram improvements?
       
    25. VTae

      VTae Member Benefactor

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      Can someone elaborate on that? If only hair cells are restored, but the synapses aren't connected to the nerves/brain, then how is that helpful? Won't these hair cells be dead weight?
       
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    26. Hottopic29

      Hottopic29 Member Benefactor

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      There are other drugs in the works to repair synapses so maybe both will be needed.
       
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    27. VTae

      VTae Member Benefactor

      Tinnitus Since:
      09/2022
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      Yes but regardless, if there was any improvement in their trial (the 10% they claim), then somehow it worked. But that sounds physically impossible. How could it have helped if there are no synaptic connections? Is the data just wrong? What really is going on here? This sounds so sketchy.
       
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    28. SmallRonnie
      Ape-like

      SmallRonnie Member Podcast Patron Benefactor

      Location:
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      I thought I read somewhere that new synapses will grow if the hair cells are regenerated but can't remember where.

      Cochlear implants improve hearing so why wouldn't regenerating hair cells work.
       
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    29. VTae

      VTae Member Benefactor

      Tinnitus Since:
      09/2022
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      Cochlear implants send electric signals directly to the nerves underneath, though, no? So they don't need these nerves to reconnect, they could just brute-force a current strong enough to get there.

      Regardless, I have no idea what I'm talking about, I'm just trying to understand. So, I'd appreciate if someone could find that citation.
       
    30. Chad Lawton

      Chad Lawton Member

      Tinnitus Since:
      2/19/18
      Cause of Tinnitus:
      Possible Ototoxicity + Noise Exposure
      The new hair cells that are created using FX-322 do form synaptic connections. The original damaged hair cells that are still in place and have lost their synaptic connection before FX-322 administration will not form synaptic connections after FX-322 administration.
       
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