IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

Discussion in 'Research News' started by XDR, Jul 4, 2016.

    1. Ian Mac

      Ian Mac Member

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Vestibular Nueritis, loud music (dubstep)
    2. AUTHOR
      AUTHOR
      XDR

      XDR Member

      Tinnitus Since:
      05/2016
      Cause of Tinnitus:
      Listening to BS
      Prossibly, will have to look into it. Ventilin doesnt help T directly but makes me sleep better, sometime I will wake with sleep aponia(and associted BP spike), with Ventilin I wont. Might give Oxytocin a go.

      I measure my BP and it was a insane 170/120!, This morning 150/100. I had 3 bags of potatoes chips (sky high salt intake) and coffee, because I've been avoiding these for months. Little wonder T has spiked.

      I'm going to get some BP meds today and will report back when I get some results.
       
    3. lapidus

      lapidus Member Benefactor

      Location:
      Sweden
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Noise induced
      What do you mean?
       
    4. Ian Mac

      Ian Mac Member

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Vestibular Nueritis, loud music (dubstep)
      FYI when you have hydrops the only recommendations the doctors can give is to avoid caffeine and salt and take a diuretic. I've never noticed caffeine or salt doing anything to my T, food has no effect on my T, and although I've been diagnosed with hydrops I don't actually think I have it, but you are explaining the symptoms, especially the salt and coffee like I said those are the two things I was told to avoid since was diagnosed with hydrops.. The oxytocin spray is nice but don't expect an immidiately dropping T.
       
    5. lapidus

      lapidus Member Benefactor

      Location:
      Sweden
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Noise induced
      Again, you should post about your experience with oxytocin in this thread:
      https://www.tinnitustalk.com/threads/the-love-hormone-may-quiet-tinnitus.17618/
       
    6. gary
      Transparent

      gary Member Benefactor

      Location:
      Macomb, MI. USA
      Tinnitus Since:
      07/2012
      Cause of Tinnitus:
      Who Knows
      Yes, very good information. This is exactly what the symptoms I have are and what a E-COG ((Electrocochleography) bares out. My E-COG in the right T ear is always in double digits, left ear single digits. My ENT told me if we can get the right in signal digits you're T will go away. Well there have been two occasions where my T was all most undetected, and it just so happened in the four years I have been seeing him my appointment was on that same day, he did an E-COG & both time my right T ear reading was in the signal digit, actually lower that mt good left ear. This does not happen very often where the noise is almost completely gone, but now after reading your comments and seeing the video it all make perfect sense. At least now with a pretty good certainty, I can have a label to put on it.

      Thank you
       
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    7. Ian Mac

      Ian Mac Member

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Vestibular Nueritis, loud music (dubstep)
      Hydrops is a medical condition I'm not talking about oxytocin spray. XDR is reporting the symptoms of cochlear hydrops, including salt and caffeine affecting his T. I just wanted to bring the condition to his attention.
       
    8. lapidus

      lapidus Member Benefactor

      Location:
      Sweden
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Noise induced
      Ok, but you wrote:

      And I remember that you posted something in the oxytocin thread that you had bought oxytocin spray. So I'm a bit confused.
       
    9. Ian Mac

      Ian Mac Member

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Vestibular Nueritis, loud music (dubstep)
      Clearly.
       
    10. AUTHOR
      AUTHOR
      XDR

      XDR Member

      Tinnitus Since:
      05/2016
      Cause of Tinnitus:
      Listening to BS
      Final update

      After a whole series of tests and months on IGF1, I can say that the treatment did not work. After a few traumatic life events, my hearing and T is now worse.

      Speaking to a neurologist, he agreed that the cause (and cure) is a vascular issue/treatment. IGF1 was a good precautions or stage 1 treatment to regenerate any dead nerve cells but the vascular issue remain. Its about me waiting for next generation MRIs that have the mm resolution to see the damaged blood vessels using radio tracers. Then a surgical treatment can be devised, so its a waiting game until then...
       
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    11. parsky

      parsky Member

      Tinnitus Since:
      8/1/17
      Cause of Tinnitus:
      Unknown
      How did you obtain the IGF-1 and figure out how to do the injections yourself?
       
    12. AUTHOR
      AUTHOR
      XDR

      XDR Member

      Tinnitus Since:
      05/2016
      Cause of Tinnitus:
      Listening to BS
      ^ Anti-aging clinics and YouTube.

      Logging back in after 2 years. I've done 3 courses of IGF1 since, both acute high dose and long chronic dosage and little to no effect on hearing. If it did work then body builders would have amazing hearing, in reality it's the opposite.

      The cure is microsurgery in the vessel supplying the cochlea and not any chemical.
       
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    13. Drone Draper
      Jaded

      Drone Draper Member

      Location:
      U.K.
      Tinnitus Since:
      12/2018
      Cause of Tinnitus:
      NIHL, ETD and work stress
      A few of my acquaintances have done IGF-1 for bodybuilding purposes. Unfortunately they're total douches, so I don't want to reach out to them.

      OP - you got your injections into your arms, yes?
       
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    14. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      It works as an intratympanic injection. I've never seen this thread until now but I am happy to have found it. I too have found ample evidence that this would cure acute stage hearing loss and perhaps work on chronic cases as well. It is implicated in the regeneration of hair cells. The question is why haven't the ATA or BTA brought any attention to this? Possible reasons:
      1. They suck at researching and don't know.
      2. They think they are geniuses and have made up their minds that it won't work.
      3. They actually want to stop people from getting viable treatments and purposefully misguide the course of research.

      Can anyone else think of any other possible reason?
       
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    15. Markku
      Inspired

      Markku Founder Staff Benefactor Hall of Fame Advocate

      Tinnitus Since:
      04/2010
      Cause of Tinnitus:
      Syringing
      From our most recent Tinnitus Talk Podcast episode with David Stockdale from the BTA:

      A World Without Tinnitus — David Stockdale (British Tinnitus Association)

      Promoting or not promoting upcoming potential treatments (starts at 43:57)
      Promoting or not promoting currently available treatments (starts at 52:43)


      Further discussion on the podcast episode should go in this thread:

      https://www.tinnitustalk.com/threads/episode-2-a-world-without-tinnitus-—-david-stockdale-british-tinnitus-association.33906/
       
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    16. AUTHOR
      AUTHOR
      XDR

      XDR Member

      Tinnitus Since:
      05/2016
      Cause of Tinnitus:
      Listening to BS
      I would not risk an intratympanic injection, too many horror stories. I'd rather flood my body with IGF1 than do that, it's insane risk. Lots of witch doctors offer this, they charge $6,000 for $15 worth of IGF1 and you take the risk. I know people are desperate for a cure but please don't risk making your life insufferable.

      I can't speak for BTA or ATA. Working in research I can say funding is an issue as well as bandwagon effects.

      Tinnitus requires several fields to find a cure. I strongly suspect it's an overpressurization of the ear due to a micro tear of the vessel causing water hammer (blood hammer). I think a cure would be a stint (flow restricting) being surgically implanted as a cure. So it's surgical and mechanical.
       
    17. AUTHOR
      AUTHOR
      XDR

      XDR Member

      Tinnitus Since:
      05/2016
      Cause of Tinnitus:
      Listening to BS
      Lol I never said I wasn't a douche too. I can tell you now they have really bad tinnitus. It's to do with very high blood pressure rupturing the vessel I'm talking about. I did a high dose but they did much higher than I did. And they have worse tinnitus.

      In relation to above, IGF1 will heal nerves. It did the wonder job of removing a lot of my aches and pains. Also I look years younger, so it works. But the mechanical failure causing tinnitus remains. A scar will heal quickly but a scar is not gone.

      Injections into legs, stomach, arms. I do rotations to make sure the skin doesn't get damaged. I have done hundreds of injections myself since then.
       
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    18. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      You just made all of that up didn't you?
      Name 1 single clinic that offers IGF-1 injections in the eardrum.
       
    19. AUTHOR
      AUTHOR
      XDR

      XDR Member

      Tinnitus Since:
      05/2016
      Cause of Tinnitus:
      Listening to BS
    20. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
    21. AUTHOR
      AUTHOR
      XDR

      XDR Member

      Tinnitus Since:
      05/2016
      Cause of Tinnitus:
      Listening to BS
      I read in thread that the clinic was charging $6000 for the treatment.

      I DIY'd the treatment for a fraction of that, same results...
       
    22. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      You injected prp into your eardrum?
       
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    23. Terminator

      Terminator Member

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Sound trauma
      You started with HGH in July 2016. Did it affect your tinnitus at all? I have tinnitus from sound trauma. Do you think HGH affects me better? And how is your tinnitus now? You still on HGH? I'm a powerlifter so my tinnitus is usually higher the day after working out.
       
    24. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      That clinic doesnt inject with IGF-1. They use blood platelets and bone marrow which include many growth factors, not just IGF-1.
      You DIY'd two weeks of intratympanic injections? That's quite a talent.
       
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    25. AUTHOR
      AUTHOR
      XDR

      XDR Member

      Tinnitus Since:
      05/2016
      Cause of Tinnitus:
      Listening to BS
      I'd probably say little to no effect to be honest. All the salvage treatments had a narrow window of recovery from trauma, Prednisone is the primary (controversial) treatment for SSHL. 2 years after the fact, I doubt it. But if you have the cash why not, I'd recommend IGF1-LR3, it's cheaper but used to treatment for nerve damage. HGH too short a half life and expensive.

      Along with HGH and IGF1 I did exercise and looked at ways reducing stress. I'm the same after I do weights or lifting something heavy I get worse tinnitus. To me this effect is directly related to an increase in blood pressure. I made an effort to lose weight and eat healthier, thus reduce blood pressure, so tinnitus is actually better. Now after doing weights the tinnitus doesn't increase as much. One can also experiment with vasodilators, I was on one, can't remember which, common high blood pressure medication that helps reduce tinnitus after exercising. My brother was a pro body builder, he has bad tinnitus, again due to high BP.

      Think of tinnitus as inner ear scar tissue, no drug will reverse it. High BP is your enemy, this will dictate how bad it is (also depending on initial trauma)..
       
    26. Little Lamb

      Little Lamb Member

      Tinnitus Since:
      Jan 2019
      Cause of Tinnitus:
      Noise induced
      Hi there! I just read the IGF-1 study you referred to and contacted the research designer to ask if he thinks doctors in Japan would be willing to do this treatment.

      I'm not hopeful for a reply so could you point me in the right direction for obtaining the IGF-1? I don't plan on injecting it into my ears and will of course exercise caution with the dosing.

      I haven't read about the other drugs you mentioned but would probably also be willing to give them a go.

      Thanks for sharing and good luck!
       
    27. Daniel Lion
      Ape-like

      Daniel Lion Member Benefactor

      Location:
      se asia
      Tinnitus Since:
      2017
      Cause of Tinnitus:
      Noise trauma, hearing loss
      Hello Little Lamb,

      My name's Daniel.

      Injections into the tympanic membrane, or ear, are most effective.

      People do it with steroids all the time. Scary, but most effective.

      Do you live in Japan?

      I live in Laos... Good luck.
       
    28. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      I have been researching my butt off about all of this since I got tinnitus and I even went to Korea to get a risky procedure involving a large amount of eardrum injections and I am convinced that IGF-1 is the answer. I do not think it is approved for human use in Japan or anywhere, hopefully I am wrong. If you do find a doctor to inject your ears with it keep us posted and good luck!
       
    29. JohnAdams
      Starving

      JohnAdams Member Benefactor Hall of Fame

      Location:
      here
      Tinnitus Since:
      it started.
      Cause of Tinnitus:
      hearing loss
      WRONG. Notch1 inhibitor drugs regenerate hair cells and restore hearing in mammals.
       
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    30. Little Lamb

      Little Lamb Member

      Tinnitus Since:
      Jan 2019
      Cause of Tinnitus:
      Noise induced
      Hi Daniel! I live in the USA. I might go to Korea now after reading about the clinic there but it is a long way and a lot of money but I think this is an emergency so I must... I don't know what to do! While in asia it would be a good time to attend some kind of holistic, relaxing mind+body oriented retreat center.
      Good luck to you too! Thanks for your message. It's my first post and pretty nice to hear a reply!

      Hi JohnAdams,

      How do you do? I must have at first glossed over your post about this clinic in Korea. How marvelous! I'm really pleased to hear that you decided to go for it! I'm casually browsing airfare and lodging. I wish I had seen this sooner!
      How did you come to find and trust this clinic and have you discovered any similar ones?
      Navigating another country's medical system to find good quality care is a little daunting but I've done it many time before. ‍♀️

      How long after T did you start your treatment? I'm four months into both T and H.

      Thanks for your message!
       

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