Intratympanic Steroid Treatment For The Prevention Of Inner Ear Toxicity Associated With Cisplatin

[Tinnitus Talk]

Tinnitus Talk submitted a new resource:

Intratympanic Steroid Treatment For The Prevention Of Inner Ear Toxicity Associated With Cisplatin (version 1.0) - To determine if cisplatin ototoxicty can be prevented by intratympanic administration of steroids.

In this study we will aim to determine if cisplatin ototoxicity can be prevented by intratympanic administration of corticosteroids.


Estimated Enrollment: 20
Study Start Date: January 2011
Estimated Study Completion Date: January 2012
Estimated Primary Completion Date: January 2012 (Final data collection date for primary outcome measure)

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[Frédéric]

https://clinicaltrials.gov/ct2/show/NCT01285674
Status: still unknown. Estimated study completion date: January 2012. I did not find any results on the net about this clinical trial. I sent an e-mail today to Peter Gilbey, the contact of the clinical trial, to ask for the results.

I only find results about a similar study on mice:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720789/

 

[Frédéric]

Peter Gilbey kindly replied me today:

Dear Frederic

I'm sorry to inform you that this study was never performed.
I would, however like to refer you to a study by Prof. Shupak:
Prevention of Cisplatin-Induced Hearing Loss by Intratympanic Dexamethasone: A Randomized Controlled Study.
Marshak T, Steiner M, Kaminer M, Levy L, Shupak A.
Otolaryngol Head Neck Surg. 2014 Jun;150(6):983-90. doi: 10.1177/0194599814524894. Epub 2014 Mar 11.
Perhaps this will be of help.
Best of luck,

Peter