Lenire — Bimodal Stimulation Treatment by Neuromod

Discussion in 'Treatments' started by Tinnitus Talk, Apr 20, 2019.

    1. GlennS

      GlennS Member Podcast Patron Hall of Fame

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      Loud music
      I would really fish around for other hobbies if I were you. Not all of them require the same sort of organized mental focus as writing fiction, but Netflix and videogames are obviously too passive for you.
       
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    2. uae96
      Thinking

      uae96 Member

      Tinnitus Since:
      6/14/2015
      Cause of Tinnitus:
      Noise induced
      Again I want to mention that I was told Lenire works best for people with hyperacusis. Why? I don’t know.
       
    3. jmasterj
      No Mood

      jmasterj Member Benefactor

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Acoustic?
      That is what they found in the trials. Most people with hyperacusis were "super responders". Interestingly enough they told a few users they aren't seeing that correlation as much with the release now.
       
    4. Lola808
      Amazed

      Lola808 Member Benefactor

      Location:
      Honolulu
      Tinnitus Since:
      4/2020
      Cause of Tinnitus:
      High frequency hearing loss wearing headphones to bed
      I am waiting for a reply back from Neuromod. I know COVID-19 has things locked up. Wonder when Neuromod might open up again.
       
    5. Croaker
      Torn

      Croaker Member

      Tinnitus Since:
      01/2019
      Cause of Tinnitus:
      Unknown
      I hope that holds true with the Michigan device. I wonder if Shore has mentioned something similar?
       
    6. Bartoli

      Bartoli Member

      Tinnitus Since:
      2009,worsened 2019
      Cause of Tinnitus:
      Noise
      I wonder if those users are just desensitizing their auditory system and thereby improving their sound tolerance, making the hyperacusis and reactive tinnitus better too.

      I'm aware not every hyperacusis patient benefits from desensitization through exposure (or white noise), but apparently some do.

      Just a thought.
       
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    7. alanisnotadj
      Batty

      alanisnotadj Member Benefactor

      Location:
      Germany
      Tinnitus Since:
      1992 (got much worse in 2018)
      Cause of Tinnitus:
      Loud noise exposure
      Significant improvement of my tinnitus in just 5 days. It's been two days in a row where it is hardly noticeable when I am outside. So glad I am back on the first settings. Let's see how things evolve.
       
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    8. lucy_snow

      lucy_snow Member

      Tinnitus Since:
      2018.03
      Cause of Tinnitus:
      hearing loss/ibuprofen
      Hi, do you have any hearing loss? :)
       
    9. alanisnotadj
      Batty

      alanisnotadj Member Benefactor

      Location:
      Germany
      Tinnitus Since:
      1992 (got much worse in 2018)
      Cause of Tinnitus:
      Loud noise exposure
      35 dB at 8000 Hz then it goes downhill... I can't hear anything above 9-10 kHz.

      I am 45.
       
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    10. NeoKortex88

      NeoKortex88 Member

      Tinnitus Since:
      3 month
      Cause of Tinnitus:
      severe stress
      I am 32 and can only hear up to 13500 Hz. Will I only be able to hear up to 8000 Hz at 45 years old too?
       
    11. Bartoli

      Bartoli Member

      Tinnitus Since:
      2009,worsened 2019
      Cause of Tinnitus:
      Noise
      Good to hear. Is your tinnitus pitch in your hearing range, or is it above the frequencies you can still hear? Trying to figure out if that is a predictor of what makes it work for some people. (Although they must have checked that out at Neuromod, I hope)
       
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    12. alanisnotadj
      Batty

      alanisnotadj Member Benefactor

      Location:
      Germany
      Tinnitus Since:
      1992 (got much worse in 2018)
      Cause of Tinnitus:
      Loud noise exposure
      Well, to be honest I don't really know. It seems like I have a variety of sounds, but I am pretty sure they are all in the high frequencies.

      I don't remember Neuromod checking where exactly my tinnitus was. I am actually scheduled to do a HD "acouphénometrie" in Paris in July where they will test my hearing over 8kHz as I am really curious to find out where my hearing loss is.
       
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    13. hans799
      Mellow

      hans799 Member Benefactor

      Location:
      Hungary
      Tinnitus Since:
      Born with it
      Cause of Tinnitus:
      Worsened Dec 2016 by headphones
      2 weeks in to my restart of Lenire with the first setting and 2×30minutes a day.

      Tinnitus is all over the place. My 2016 noise is fluctuating all over the place, sometimes it's nearly absent (as in, I have to concentrate to hear it with my ears plugged), sometimes it's annoying. Last time around I was having similar fluctuations at this same point in time. If it goes like last time, the fluctuations should clear up & I should begin improving compared to baseline in 1-2 more weeks. Really looking forward to it.
       
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    14. DaveFromChicago

      DaveFromChicago Member Benefactor

      Tinnitus Since:
      01/2014
      Cause of Tinnitus:
      Headcold/Flu
      I am curious about why Lenire did not feature you as a prime interviewee, since your report of such success is far greater than anything mentioned by the other trial participants.
       
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    15. JackJ

      JackJ Member

      Tinnitus Since:
      May 2012
      Cause of Tinnitus:
      Medication
      After the followups from the trial they asked I would be willing be take part in a video testimonial of my experience with the device but I declined as I'm camera shy. In hindsight I should have.

      Since completing the second round of treatment I've been approached again to take part in a testimonial. This time I agreed but it was cancelled. If they reschedule in the future and ask me again I would gladly oblige.
       
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    16. alanisnotadj
      Batty

      alanisnotadj Member Benefactor

      Location:
      Germany
      Tinnitus Since:
      1992 (got much worse in 2018)
      Cause of Tinnitus:
      Loud noise exposure
      It seems that we are going through the exact same thing. My tinnitus is also fluctuating wildly but with moments where it is very very low. Last night I fell asleep without any sound enrichment for the first time in 18 months. Normally I would wake up with screaming tinnitus but this morning was so peaceful I could not believe it. Then the tinnitus was on the up again this afternoon.

      But so far the positives clearly outweigh the negatives.
      Let's hope things keep going this way.
       
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    17. UKBloke

      UKBloke Member Podcast Patron Benefactor

      Tinnitus Since:
      1991
      Cause of Tinnitus:
      Loud Music / family history
      Really pleased for you!
       
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    18. ThomasC
      Lonely

      ThomasC Member Benefactor

      Location:
      France
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      hearing loss
      I've made my decision. I will give Lenire a try next year. There is something like 50% of success rate and there are very few cases of permanent worsening.
       
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    19. Mathew Gould

      Mathew Gould Member Benefactor

      Tinnitus Since:
      6/2017
      Cause of Tinnitus:
      Neck/Jaw misalignment
      I haven't been paying attention to this thread in months... I thought Lenire was a failure basically. Did people start improving over time??
       
    20. ThomasC
      Lonely

      ThomasC Member Benefactor

      Location:
      France
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      hearing loss
      it's neither a failure nor a success. Trolls keep saying that is a complete fail but the reality is it works for some and it doesn't for others.
       
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    21. Chinmoku

      Chinmoku Member Benefactor

      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Unknown, possibly medication
      Posting very little these days, as I am struggling really hard.

      Quick question for anyone who has tried LENIRE: Have any of you tried LENIRE when your tinnitus was possibly due to ototoxic medication and GABA drugs in particular (benzos, gabapentin/pregabalin, finasteride, Z-drugs)?

      As the tinnitus associated with GABA drugs withdrawal seems to be of a very specific kind, I'm wondering whether LENIRE could potentially help with that or not.

      Thanks in advance.
       
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    22. JackJ

      JackJ Member

      Tinnitus Since:
      May 2012
      Cause of Tinnitus:
      Medication
      Hi Chinmoku,

      My tinnitus was caused by ototoxic medication. A powerful non-steroidal anti-inflammatory a doctor prescribed to me for some back pain as she was too nervous to prescribe a perfectly safe codeine pill. That was 8 years ago and I'm still living with the consequences. Over the years, at different times, it was made worse by Doxycycline and Ciprofloxacin. I quickly discontinued both of those when they caused my tinnitus to spike. Both are known ototoxics. To say I'm highly sensitive to ototoxic medication is an understatement. Also when you have tinnitus I believe it's much easier for it to be made worse than it was to get it in the first place.
      I now use the attached as my ototoxicity bible.
      It's an excellent reference.

      You will need to be very careful with ALL medications in the future. Even common ibuprofen and aspirin can cause tinnitus.

      Hopefully the attached will help you and anyone else concerned with ototoxic medication.
       

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    23. GlennS

      GlennS Member Podcast Patron Hall of Fame

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      Loud music
      Propecia causes tinnitus???
       
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    24. hans799
      Mellow

      hans799 Member Benefactor

      Location:
      Hungary
      Tinnitus Since:
      Born with it
      Cause of Tinnitus:
      Worsened Dec 2016 by headphones
      Yesterday I did both my sessions in the morning and also took armodafinil, and because of all this stimulation I expected my tinnitus to be in high gear all day long. Got just the opposite, I had an unusually quiet day. I even had a few minutes in the car when I couldn't hear anything from the "orchestra", not even the high-pitched noises I usually hear over the car. Just silence and the purr of my Honda. Felt so light and liberating.
       
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    25. Chinmoku

      Chinmoku Member Benefactor

      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Unknown, possibly medication
    26. Chinmoku

      Chinmoku Member Benefactor

      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Unknown, possibly medication
      Man that is quite a list. Thanks for that.
      Our hearing system robustness is something where evolution has failed us big time.
       
    27. Mathew Gould

      Mathew Gould Member Benefactor

      Tinnitus Since:
      6/2017
      Cause of Tinnitus:
      Neck/Jaw misalignment
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    28. lucy_snow

      lucy_snow Member

      Tinnitus Since:
      2018.03
      Cause of Tinnitus:
      hearing loss/ibuprofen
      @hans799 Are you going to use the device only with the first settings this time?
       
    29. Chinmoku

      Chinmoku Member Benefactor

      Tinnitus Since:
      10/2018
      Cause of Tinnitus:
      Unknown, possibly medication
      Yea, I know a person who was severely affected. That's why there is a finasteride withdrawal syndrome group. However, it does not hit everyone, a lot of people have zero problems with it. Like with benzos, some stop without problems, others go through hell. This person I know had his testosterone dropping to dangerously low levels, he could not work anymore, he had to go on leave six months, slowly recover, then get back to work but he is not 100% yet, it will take years. A nightmare. Probably such cases are rare, but who knows. I have no data.
       
    30. hans799
      Mellow

      hans799 Member Benefactor

      Location:
      Hungary
      Tinnitus Since:
      Born with it
      Cause of Tinnitus:
      Worsened Dec 2016 by headphones
      Yes.

      I also came up with an explanation on what might have happened to me (first timing made matters better, second timing made them worse).
      Source 1: Neuromod's clinical trial protocol https://pubmed.ncbi.nlm.nih.gov/31573942/
      Source 2: Susan Shore's 2018 study https://pubmed.ncbi.nlm.nih.gov/29298868/

      Findings:
      • PS1 is Lenire's first setting, for everyone. "PS1 consists of a sequence of tones mixed with structured wideband noise, in which the tones are synchronized in time with electrical pulses presented to the tongue" [1]
      • PS4 was the second setting for me, though this varies per patient. "PS4: Similar to PS1, except that a randomly
        varying short delay (0-30 ms) is introduced between the tone and tongue stimuli" [1]
      • Shore's trial has determined that the effect of bimodal stimulation is very dependent on timing. She found that delays as low as 5 couple ms mean the difference between increasing or decreasing tinnitus. "We show, in vivo, that auditory-somatosensory stimulation strengthened or weakened neural synchrony between fusiform cells, depending on the bimodal stimulus order and timing." [2]
      This means that according to Shore's research, the difference between Lenire's PS1 and PS4 timings is large enough to cause completely opposite effects. So what I've experienced is explained by the research. And what's still better, this predicts that PS1 will work again for me.

      By the way I had another of those nights when I just stayed up listening to how quiet my tinnitus is. Knock on wood, hope not to jinx it, but maybe I've entered the "Lenire is working its magic" phase again.
       
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