My Posting Place

there's a certain someone on the forum spreaidng outdated information that no longer applies and he also uses ignorance as an argument for failure.

he also shills the doctrines of habituation

 

He's also one of our founding fathers.

 

https://www.excelmale.com/community/threads/tinnitus.6105/
TRT discussion that isn't actually TRT

 

I remember it like yesterday. The day he spilled crates of the book "Tinnitus Retraining Therapy" into the harbor. What a revolutionary.

 

Maybe if I underwent that TRT I would be less gay.

 

it would make you more gay actually.

The Gladiators were gay and they were the most manly men on the planet.
https://www.gaypopbuzz.com/homosexuality-gladiators/

 

Is there any cure for me then?

 

Thank you doctor Pence!

 

Lots of us here are/were huge music people.
My hearing is f'ed up but I've been curious how I fare in terms of pitch discrimination. I found this cool page (needs flash so may not work on a phone) jakemandell.com/adaptivepitch/
Thankfully my pitch discrimination is still pretty good but im sure it was better before my ear problems
If any y'all like such things and such.

 

*TRT discussion that isn't cancer and doesn't make you feel like pulling out the rest of your hair cells.

 

Does anyone want to talk about Alex Jones recent events.

 

I'm going to miss the old crazy guy

 

1776 WILL COMMENCE AGAIN

 

Just remember in your heart...

BILL CLINTON IS A RAPIST

 

I'm gonna miss all the A+++++ grade memes

What if Alex Jones is the voice actor for DOOM

 

Yeah, what about him?

 

My name is actually a reference to his son John Quincy Adams. 6th president.

 

Ladies and gentlemen:
About fx322:
https://www.genengnews.com/gen-arti...all-molecule-drugs-to-treat-hearing-loss/6331
"Fx322 combines two proprietary, small-molecule drugs and delivers them in a slow-release gel.


From their patent:
https://patents.google.com/patent/US9968615B2/en

"The present invention relates to methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells"

Also from the patent:

"Among the various aspects of the present disclosure, therefore, may be noted a method for activating the Wnt pathway in a cell population to increase the capacity of the population for self-renewal, i.e., the capacity for repeated generation of daughter cells with equivalent proliferation and ‘cell fate specification’ potential, and differentiation, i.e., the capacity for generation of daughter cells specified for differentiation"



I have posted ample proof that Curcumin is a notch1 inhibitor, like ly411575, DAPT, and has a similar molecular profile. But this action alone will not cause progenitor cells themselves to divide, so if you dont do that, then you will get new hair cells, but in turn deplete the progenitors. Hence the need for two drugs. I think. One to divide and maintain the number of progenitor cells while the other grows progenitor cells into hair cells, and possibly also plays a role in the differentiation into hair cells. That's where I get a little fuzzy on this. Nonetheless it is notch1 inhibition as well as wnt activation that is the key here.

Carageenan is a natural wnt activator.
https://www.ncbi.nlm.nih.gov/m/pubmed/24328990/

"Common food additive carrageenan stimulates Wnt/ β-catenin signaling in colonic epithelium by inhibition of nucleoredoxin reduction"

Remember it is the intestinal cells that are lgr5+ just like the cochlear cells.

Here is my preliminary recipe for a DIY method for curing hearing loss and tinnitus:

High doses of curcumin + carageenan.
Both readily available food products. Taken in large but safe quantities for roughly one week.

"Let thy medicine be thy food and thy food be thy medicine" -Hypocrates, the father of medicine.

More about curcumin:

https://www.ingentaconnect.com/content/ben/mc/2006/00000002/00000002/art00006

"In this study, we demonstrate that the small molecule natural product curcumin, whose medicinal properties have long been recognized in India and Southeast Asia, is a selective HAT inhibitor"

HAT = Histone acetyltransferases

https://www.ncbi.nlm.nih.gov/m/pubmed/15842781/

"Curcumin, a potent anti-tumor reagent, is a novel histone deacetylase inhibitor"

http://www.pnas.org/content/101/47/16659

"Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells"

 

I began taking large doses of curcumin again last night before bed. Just like the first time I did it, I am noticing an unexpected and drastic immediate affect on my tinnitus. It is very very low. Like, I have my life back low. Perhaps this is due to its antioxidant properties. I ordered some carageenan too, it wont be here for 5 days though. I'm still going to do the curcumin.

 

Lol is that jasterboff?

 

Won't large amounts of curcumin discolour your skin and eyes?

I am not much for looking like this.

 

Maybe, the edges of my fingernails turned yellow and the sides of my fingers. It goes away after it gets out of your system. The guy in that picture looks more like he has jaundice.

 

I just found a medical journal paper entitled "Regenerating neurons by using endogenous neuronal progenitor cells."
I can't even get it online, I had to request a library loan.
I sincerely wonder why mention of this type of stuff isn't on DecibelTx or FrequencyTx's websites.

 

"Curcumin exhibits a variety of pharmacologic properties, including anti-inflammatory, anti-carcinogenic, and anti-oxidant [17]. In recent years, the potential therapeutic values of curcumin in the treatment of neurodegenerative disease have been increasingly recognized [8], [10], [16], [3]. In vitro studies show that curcumin protected PC12 cells against amyloid-induced toxicity [8], and protected against glutamate excitotoxicity in rat cerebral cortical neurons [10]. In vivo studies have shown that curcumin can protect rat brain against ischemia injury by reducing the expression of apoptotic genes [16]. In addition, curcumin is capable of inhibiting apoptosis and neuronal loss, and improving motor function after spinal cord injury in rats [3]. All those studies indicate the neuroprotective capacities of curcumin, and raise the possibility that curcumin may promote nerve regeneration after peripheral nerve injuries"

Citation:
Ma, Liu, Yu, Wang, Chen, & Xiang. (2013). Curcumin promotes nerve regeneration and functional recovery in rat model of nerve crush injury. Neuroscience Letters, 547, 26-31.

 

"Indeed, cannabinoids have clear modulatory roles in adult neurogenesis, probably through activation of both CB1 and CB2receptors."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543605/