New Phase II Grant for Oricula Therapeutics LLC

Discussion in 'Research News' started by Shaullazar, Feb 27, 2016.

tinnitus forum
    1. Published on Friday, 12 February 2016 15:36

      Oricula Therapeutics LLC., a biotech company based in Seattle, Washington State is working to develop the first medication approved to prevent hearing loss related to aminoglycoside antibiotics.

      PR Newswire reports that the grant of USD 2 million was awarded through the Small Business Innovation Research (SBIR) Program by the National Institute of Allergy and Infectious Diseases, within the US National Institutes of Health (NIH). Oricula Therapeutics focuses on discovery of protective treatments to preserve hearing and balance from the damaging effects of medications and aging.

      The grant will be used to support completion of the preclinical phase for the biotech’s lead clinical compound, ORC-13661, and submission of an investigational drug application for subsequent clinical trials in this indication. Up to 20% of patients treated with aminoglycosides have been reported to develop measurable, irreversible hearing loss or even deafness.

      It is hoped that ORC-13661 will protect patients from hearing loss caused by these antibiotics, an important but underused class of antibacterials that can be beneficial in particularly serious infections, such as endocarditis, neonatal septicemia, and multidrug resistant tuberculosis, according to the company.

      The compound has shown 100% hearing protection in rats co-administered a 10-day course of the aminoglycoside, amikacin. “Now that the preclinical workup is assured, I’m spending much of my time designing the ideal first-in-human proof-of-concept clinical trials for our lead compound,” said Malcolm Gleser MD, PhD, CEO at Oricula.

      Source: PR Newswire; Oricula Therapeutics, LLC
       
      • Informative Informative x 1
    2. Nucleo

      Nucleo Member Benefactor

      Tinnitus Since:
      02/2011
      Not going to be useful for many of us unfortunately.
       
      • Agree Agree x 3
      • Like Like x 1
    3. Dutchy
      Not worthy

      Dutchy Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      12/2014
      Cause of Tinnitus:
      Neuronmodulation suggests noise induced?
      I'm starting to see more of these prevention treatments,i mean hearing in general (well medicine in general really)
      is all about preventing it instead of healing it with warnings concerning DB's and duration of exposure.
      Are we going to see a treatment for chronic T?,that's going to be less likely it seems.
       
    4. It still good in case of a worsening don't you think ?
      We can still use it and maintain our current level of T
       
    5. Atlantis

      Atlantis Member

      Tinnitus Since:
      02/2014
      That's of little hope when your current tinnitus level is suicidal.
       
    6. Bertman
      No Mood

      Bertman Member Benefactor

      Location:
      canada
      Tinnitus Since:
      07/2015
      Cause of Tinnitus:
      concert
      I'm not so sure about that. I've had spikes from sounds that would not cause damage to my hearing
       
    7. Nucleo

      Nucleo Member Benefactor

      Tinnitus Since:
      02/2011
      No. Only if your tinnitus has increased as a result of aminoglycoside antibiotic ototoxicity.

      The use of this is extremely narrow.
       

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